Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Medical Economics Analyst
$89K - $107K *
Join a team that's transforming healthcare through data-driven insights. As a Senior Medical Economics Analyst, you'll lead analytics initiatives, mentor a team, and collaborate with leaders to enhanc...
2 weeks ago
Software Engineer II - Java, Spring, AWS, CI/CD
$121K - $191K *
Join the team to design and develop scalable software solutions for healthcare supply chain transactions. Collaborate with cross-functional partners to enhance the rules engine and deliver high-qualit...
2 weeks ago
Senior Decision Scientist, Core Experiences
$106K - $195K *
Empower product and engineering teams by delivering actionable insights that shape strategic decisions. As a Senior Decision Scientist, you'll leverage data to influence roadmaps and resource allocati...
Yesterday
Global Enterprise Account Manager
$201K - $239K *
Grow strategic relationships with global enterprise clients, driving EHS and ESG success. Leverage consultative selling to expand accounts, collaborate cross-functionally, and ensure exceptional custo...
6 days ago
$80K - $95K *
Engineer automated systems to enhance production efficiency and quality. Lead projects from design to implementation, optimizing processes through data analysis and collaboration with cross-functional...
2 weeks ago
Senior Specialist, Federal Data Engineer
$110K - $130K *
Drive innovation by developing scalable data pipelines and analytics solutions. Collaborate with teams to translate complex business problems into actionable insights across diverse domains, ensuring...
2 weeks ago
Senior Site Reliability Engineer
$160K - $208K *
Transform our technology infrastructure by enhancing automation, troubleshooting issues, and fostering collaboration. Bring your expertise to support a scalable infrastructure platform that manages di...
Reposted today
Anaplan + Tagetik Alliance Partner/Senior Manager
$94K - $266K *
Transform partnerships into strategic growth by developing joint solutions, driving co-marketing efforts, and enhancing executive relationships to create lasting value in a dynamic ecosystem...
Reposted 1 week ago
$195K - $325K *
Join a team that's shaping the future of AI in healthcare by leading multi-year strategies, resolving complex technical challenges, and influencing executive decisions across the organization to ensur...
1 week ago
$100K - $125K *
Join our dynamic finance team as you drive margin and profitability through detailed analysis and strategic insights. Collaborate with senior leadership to transform data into actionable initiatives t...
2 weeks ago
Senior Analyst, Private Debt & Equity Operations
$89K - $134K *
Grow your career with a dynamic role focused on private debt and equity operations. Leverage your expertise in asset lifecycle servicing while guiding junior team members and driving process improveme...
3 weeks ago
$125K - $150K *
Take ownership of a fully distributed engineering team, driving delivery, quality, and growth while fostering a culture of communication and continuous improvement. Collaborate with cross-functional p...
1 week ago
$125K - $150K *
Lead a distributed engineering team to deliver high-quality software solutions. Foster a culture of ownership and continuous improvement while collaborating with cross-functional partners to drive bus...
1 week ago
Sr. Principal Software and AI Engineer
$137K - $182K *
Architect and drive AI-powered applications for drug development, focusing on protocol generation and clinical trials. Lead technical direction, mentor engineers, and ensure compliance while fostering...
2 weeks ago
Software Architect (AWS/Azure)
$101K - $135K *
Join a team that's shaping the future of healthcare technology by designing and enhancing our build and delivery infrastructure. Collaborate with architects and developers to implement best practices...
2 weeks ago
$110K - $130K *
Innovate and implement robust disaster recovery solutions for enterprise DevOps, ensuring critical infrastructure recoverability. Oversee Jenkins, Bitbucket, and JFrog Artifactory environments while e...
2 weeks ago
Account Executive - Attribute™, North America
$110K - $130K *
Accelerate growth by building a new region from scratch, driving sales, and establishing customer success stories for a groundbreaking FinOps solution. Own the full sales cycle, focusing on net-new lo...
Today
CGI OpenGrid Implementation Analyst, Sr. Associate
$77K - $202K *
Lead the charge in implementing CGI OpenGrid solutions, analyzing client needs, and guiding junior team members while enhancing operational efficiency through innovative business software solutions...
4 days ago
Senior Engineer (Engineering & Construction) - Data Center
$110K - $130K *
Optimize complex mechanical and electrical systems for data centers, ensuring high availability and reliability. Lead design, engineering, and project management activities while collaborating with mu...
2 weeks ago
$100K - $120K *
Drive budget management and project support for public health initiatives, ensuring accurate tracking, analysis, and reporting. Collaborate with leadership to enhance operational efficiency in a dynam...
2 days ago
$135K - $160K *
Join a team of expert engineers to innovate a Kubernetes resource management platform, enhancing DevOps productivity and addressing complex engineering problems in a dynamic environment...
Reposted 1 month ago
Principal Engineer Team Lead, Behavior Safety & Metrics
$240K - $330K *
Transform autonomous driving evaluation by leading initiatives that bridge model performance and real-world outcomes. Collaborate with cross-functional teams to develop metrics and tools that enhance...
Today
MSSP Revenue Assurance Analyst
$108K - $149K *
Drive revenue operations excellence by enhancing MSSP processes and systems. Collaborate with cross-functional teams to operationalize strategies, streamline workflows, and support partner lifecycle m...
3 weeks ago
Director, Application Development Engineering
$146K - $269K *
Shape the future of enterprise software by leading multiple engineering teams, driving application development, and implementing best practices. Collaborate cross-functionally to enhance quality and s...
5 days ago
Senior Strategist, Paid Social
$88K - $98K *
Join a team that's shaping the future of paid social strategy for top consumer brands. Drive growth through innovative, data-driven campaigns on platforms like Meta, TikTok, and YouTube, while mentori...
Reposted 3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.