Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$110K - $130K *
Join a team that's central to coordinating complex enterprise software releases across multiple platforms. You'll lead the release process, ensuring predictability and compliance while collaborating w...
1 week ago
$250K - $300K *
Empower the future of AI in commerce media by leading strategy and execution across AI Labs and Data Science. Drive customer engagement, scale capabilities, and enhance product impact while building a...
Reposted 4 days ago
Principal Fraud Analyst (Data Science), Digital Payments Fraud Strategy US
$128K - $205K *
Drive the analytical strategy for fraud risk mitigation in digital transactions. Collaborate with cross-functional teams to develop metrics and frameworks that enhance decision-making and risk detecti...
Yesterday
$75K - $90K *
Elevate your career by ensuring top-notch quality in technical deliverables. Collaborate with stakeholders to enhance cybersecurity documentation and support critical DoD programs while maintaining hi...
Yesterday
$100K - $110K *
Unlock potential by leading complex projects within a dynamic ePMO, driving cross-functional alignment, and ensuring timely execution while communicating effectively with senior leadership to foster t...
Yesterday
Senior Strategy & Decision Analyst
$120K - $145K *
Help us ensure high-quality decision-making by collaborating with leaders to frame strategies and analyze options, driving impactful decisions that align with organizational goals and values while fos...
6 days ago
$125K - $150K *
Lead the charge in managing and optimizing cloud infrastructure across multiple platforms. Collaborate with teams to enhance product reliability and streamline operations while ensuring security and c...
3 weeks ago
Enterprise Sales Director, CPG
$130K - $160K *
Discover your potential as you drive enterprise sales in the CPG sector, building relationships with iconic brands. Leverage insights and solutions to develop strategies that enhance client success an...
2 weeks ago
Forward Deployed Process Consultant- R37
$113K - $226K *
Lead the charge in optimizing healthcare processes by bridging strategy and execution. Collaborate with teams to enhance coding workflows, drive change management, and ensure alignment with strategic...
3 weeks ago
$150K - $180K *
Inspire innovation by leading a data department to shape analytics strategies, manage operational delivery, and execute data initiatives that empower business decisions and drive growth across multipl...
Reposted today
Senior Electrical Design Engineer
$135K - $180K *
Drive innovative electrical design solutions for high-density compute environments. Collaborate across teams to ensure compliance with industry standards while mentoring junior engineers. Make a signi...
1 week ago
$110K - $130K *
Drive innovative software solutions by designing, developing, and testing systems-level software. Collaborate with cross-functional teams to meet operational specifications and enhance SAP functionali...
3 weeks ago
Research Data Analysis Supervisor 2 - Remote - 141980
$111K - $211K *
Advance your career by leading impactful research in public health and family planning. Drive data analysis and quality assurance efforts across low- and middle-income countries, collaborating with di...
6 days ago
Enterprise Risk Management Data Analytics Lead
$156K - $181K *
Elevate enterprise risk management by designing and executing data analytics solutions. Collaborate with stakeholders to enhance reporting processes and deliver insights that drive strategic decision...
2 days ago
Staff Software Engineer- AI Platform
$150K - $180K *
Develop and manage scalable AI infrastructure solutions, ensuring secure access to foundation models. Collaborate with cross-functional teams to enhance platform capabilities and drive AI adoption whi...
1 week ago
$88K - $118K *
Join us to analyze and document business and technical requirements, implement process improvements, and support ERP projects. Collaborate with teams to ensure accurate reporting and optimize system s...
6 days ago
$110K - $130K *
Champion customer solutions by rapidly prototyping and deploying AI-driven applications. Collaborate with cross-functional teams to enhance product capabilities and drive adoption, ensuring impactful...
1 week ago
Senior Director, Analytical Sciences
$215K - $240K *
Shape the future of drug development by leading analytical strategies, ensuring compliance and optimization of processes across lifecycle stages, and collaborating with cross-functional teams and exte...
Reposted today
Sr. Performance Strategist, Collections
$120K - $170K *
Contribute to performance optimization by diagnosing shifts in a $30B portfolio. Leverage data insights to drive strategic recommendations, enhance client outcomes, and collaborate with cross-function...
1 week ago
Program Analyst (Springfield VA)
$120K - $130K *
Transform the future of geospatial intelligence by supporting R&D program planning, financial execution, and acquisition activities. Collaborate with diverse teams to ensure effective management of fu...
1 week ago
Sr. Manager, Ads Product Marketing
$163K - $336K *
Advance product marketing strategies for automation solutions, leading a team to enhance advertiser performance through effective go-to-market execution and cross-functional collaboration, while simpl...
4 weeks ago
Director of Engineering Services
$120K - $145K *
Lead and optimize manufacturing processes across multiple sites, driving operational excellence and continuous improvement. Collaborate with cross-functional teams to enhance efficiency, reliability...
Reposted 1 week ago
$126K - $154K *
Unlock your potential as a Senior Accountant, driving financial accuracy and compliance. Collaborate across teams to enhance systems, oversee key accounting functions, and support audits in a dynamic...
1 week ago
Staff Engineer - INFOR M3 Functional Consultant (Supply Chain)
$110K - $130K *
Lead the configuration and support of Infor M3 non-finance modules, driving business process analysis and continuous improvement. Collaborate with teams to ensure effective implementation and user tra...
3 weeks ago
Senior Customer AI Engineer - Token Factory
$209K - $262K *
Transform customer AI workloads by leading the transition from proof-of-concept to production. Collaborate with engineering teams to ensure stable, scalable deployments while driving performance and c...
3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.