Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Technical Consultant- Enterprise Data Engineer
$84K - $142K *
Join a team that's redefining enterprise database solutions, collaborating with clients to design and implement robust geospatial data management strategies. Leverage your expertise to enhance workflo...
Today
$150K - $170K *
Unlock potential by leading hands-on security engineering efforts to modernize cybersecurity for a major federal agency. Collaborate with teams to remediate vulnerabilities and enhance cloud infrastru...
Today
$167K - $196K *
Drive risk mitigation strategies by analyzing account takeover and scam threats. Collaborate cross-functionally to enhance user protection and platform integrity, shaping metrics and prevention tactic...
3 weeks ago
Sr Domain Consultant (AI Security)
$232K - $320K *
Empower your career by providing expert guidance in AI security solutions. Lead technical validations, influence product roadmaps, and architect comprehensive security strategies to protect AI applica...
2 weeks ago
ASC Development Leader - Central
$114K - $171K *
Join a team that's driving growth in the cardiovascular ASC market by developing strategic relationships and orchestrating complex opportunities across the U.S. Collaborate with diverse stakeholders t...
4 days ago
$146K - $229K *
Drive the AI roadmap and deliver secure, scalable solutions that enhance decision-making and streamline workflows. Lead teams from experimentation to production, ensuring measurable business value and...
Today
Technical Implementation Analyst
$80K - $95K *
Analyze and deliver tailored technical solutions, collaborating with teams to implement AI-driven workflows and support complex data migrations, ensuring high-quality service outcomes and stakeholder...
Today
$100K - $120K *
Engage in budget management and project support for public health initiatives. Collaborate with program leadership to ensure accurate financial tracking and reporting, while adapting to evolving prior...
2 days ago
$100K - $120K *
Drive program operations support by managing logistics, personnel processes, and documentation for a dynamic public health initiative. Collaborate with leadership to enhance efficiency and ensure comp...
6 days ago
Cloud Application & AI Security Engineer
$93K - $140K *
Elevate cloud security by enhancing standards and implementing risk-based controls across Azure and AWS. Collaborate with teams to secure applications and support AI initiatives, ensuring robust gover...
6 days ago
HSE and Portfolio Performance Lead
$110K - $130K *
Lead the charge in enhancing health, safety, and environmental performance across data center construction projects. Collaborate with teams to ensure compliance with OSHA standards and drive continuou...
6 days ago
Senior Full-Stack Engineer (AI-Native)
$110K - $130K *
Optimize end-to-end project delivery by developing customer-facing products and internal tools. Collaborate with stakeholders to rapidly turn needs into functional solutions, leveraging AI and modern...
3 weeks ago
Technical Application Engineer - Industrial Communications products (MDS and Lentronics)
$89K - $148K *
Drive technical solutions by collaborating with sales teams and customers to enhance industrial communications products. Develop sales strategies, manage customer relationships, and ensure compliance...
Reposted 2 weeks ago
Enterprise Architect - Emerging Analytics
$134K - $209K *
Join a team that's redefining data architecture and analytics. Leverage your expertise to drive cloud adoption, modernize data platforms, and influence strategic initiatives that empower data-driven d...
4 weeks ago
Staff Security Engineer - SecOps & Threats
$231K - $265K *
Unlock potential by executing security operations, identifying threats, and developing automation to enhance incident response and security posture, while collaborating with cross-functional teams to...
Reposted today
$80K - $95K *
Grow your career with an influential role in customer success, fostering strong relationships and driving client satisfaction post-sale while managing renewals and growth opportunities in the health c...
Reposted 2 weeks ago
$103K - $185K *
Join a team that's focused on hands-on technical delivery while mentoring and developing team capabilities. Lead solution implementation, troubleshoot issues, and establish best practices to ensure hi...
5 days ago
$130K - $150K *
Join a dynamic team to lead risk management for large-scale construction projects. Drive risk identification, reporting, and mitigation strategies while collaborating with diverse stakeholders to ensu...
1 week ago
Digital Consulting Associate, Oracle Reporting & Analytics (U.S. or Canada)
$105K - $130K *
Shape the future of analytics by leading reporting initiatives and managing client relationships. Drive implementation strategies, gather requirements, and deliver impactful dashboard solutions using...
3 weeks ago
Senior Strategist, Paid Search (DTC)
$85K - $106K *
Empower clients by leading innovative paid search strategies across diverse categories. Collaborate with cross-functional teams to drive performance, optimize campaigns, and connect search tactics to...
1 week ago
Senior SAP Analyst – Global Trade Services (GTS)
$82K - $152K *
Lead the charge in optimizing Global Trade Services by enhancing SAP solutions, conducting gap analyses, and supporting the global SAP S/4HANA migration initiative while collaborating with cross-funct...
Reposted 4 days ago
Sr. Growth Marketing Manager, AI Discovery
$140K - $167K *
Champion growth by driving Chainguard's SEO and developer marketing strategies. Collaborate cross-functionally to enhance visibility and user adoption, focusing on measurable outcomes and pipeline gro...
Yesterday
$100K - $120K *
Lead the charge in managing a high-performing team of facility technicians, ensuring operational excellence and compliance while fostering a culture of safety and teamwork in a critical environment...
3 weeks ago
$150K - $195K *
Elevate client relationships by managing key accounts, driving satisfaction and growth. Collaborate with internal teams to deliver tailored solutions, ensuring long-term success and measurable ROI for...
3 weeks ago
Global Tech - Software Developer with AI, Sr. Associate
$55K - $151K *
Lead innovative software development initiatives, leveraging AI and coding expertise to design, implement, and maintain applications that drive digital transformation and enhance business operations w...
Today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.