Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$95K - $115K *
Transform banking analytics by developing and optimizing financial crime detection models. Leverage your expertise in Python and SQL to analyze complex datasets, enhance model performance, and collabo...
Yesterday
Systems Engineer (Expert) Job# 934
$130K - $155K *
Lead cross-functional engineering teams to enhance geospatial intelligence solutions, ensuring timely and accurate delivery through expert systems engineering, integration, and strategic planning acro...
5 days ago
$125K - $150K *
Unlock potential by driving new enterprise sales in cybersecurity. Own the full sales cycle, from prospecting to closing, while expanding existing accounts. Collaborate with teams to deliver tailored...
2 weeks ago
$216K - $228K *
Transform the research landscape by defining and leading user research practices that connect customer insights to product design across multiple foundational areas, driving high-quality deliverables...
1 week ago
Open Talent Network: Staff DevOps and Systems Integration Engineer
$160K - $180K *
Transform the future of cloud infrastructure by leading DevOps initiatives, enhancing systems integration, and driving innovative solutions for federal clients. Collaborate with stakeholders to optimi...
Reposted 6 days ago
$215K - $240K *
Shape the future of commercial operations by leading strategy, workflows, and data integration. Collaborate with senior leaders to enhance brand performance and drive operational excellence across cro...
3 weeks ago
Senior Application Migration Business Analyst
$140K - $211K *
Lead the charge in transforming enterprise applications through cloud migration. Drive global initiatives, mentor teams, and solve complex challenges while ensuring seamless transitions to Azure and A...
5 days ago
$110K - $130K *
Empower cross-functional teams to consolidate payment gateways, leveraging deep USA Payments expertise. Collaborate with stakeholders to analyze requirements, drive migrations, and ensure seamless int...
2 weeks ago
$170K - $200K *
Transform client relationships by leading data-driven solutions for major tech firms. Engage with executives to uncover insights, drive impactful decisions, and ensure seamless delivery across teams i...
2 weeks ago
$120K - $140K *
Join a dynamic team as you take ownership of the accounting function, managing spend, payables, and reconciliations. Drive process improvements and leverage AI to enhance workflows, ensuring accuracy...
5 days ago
Strategic Analytics & Transformation Manager
$135K - $185K *
Transform data into actionable insights by enhancing financial models, optimizing sales performance, and driving operational efficiencies. Collaborate with cross-functional teams to support strategic...
2 weeks ago
$115K - $150K *
Architect and streamline cloud network infrastructure. Support robust security and connectivity across Azure, OpenShift, and SASE platforms. Collaborate with cross-functional teams, ensuring optimal p...
Reposted 1 week ago
Senior Platform Engineer, MarTech
$145K - $165K *
Lead the charge in enhancing marketing technology platforms to optimize customer engagement and journey orchestration. Collaborate with cross-functional teams to deliver reliable solutions and improve...
3 weeks ago
$130K - $150K *
Join a dynamic team to design and develop innovative mobile solutions across Android and iOS. Take ownership of projects, collaborate with peers, and contribute to the broader tech stack while enhanci...
6 days ago
$163K - $322K *
Transform your career by leading AI cybersecurity strategy initiatives, guiding cross-functional teams, and shaping innovative solutions that enhance enterprise governance and risk management in a rap...
2 weeks ago
$163K - $322K *
Lead the charge in shaping AI cybersecurity strategies, guiding teams through complex governance and risk challenges while driving high-quality outcomes for clients across diverse technical domains...
2 weeks ago
Site Reliability Engineer (SRE)
$110K - $130K *
Unlock potential by joining a dynamic Global SRE team focused on enhancing software reliability and observability. Collaborate with teams to implement best practices and innovative solutions, ensuring...
4 days ago
$123K - $197K *
Transform the landscape of AI by architecting and optimizing cutting-edge LLMs while collaborating with diverse tech teams to innovate and enhance applications for performance and accuracy in resource...
Reposted 3 weeks ago
Senior Manager, Third Party Data Governance
$120K - $145K *
Shape the future of data governance by leading a team to manage third-party data compliance, ensuring operational excellence and regulatory adherence while fostering collaboration across business unit...
5 days ago
$75K - $90K *
Drive cross-functional collaboration and optimize supply chain processes by leading SIOP initiatives. Utilize data analytics to enhance demand planning, inventory management, and financial alignment...
Reposted yesterday
$75K - $90K *
Join a team that's transforming supply chain planning through data-driven insights and cross-functional collaboration. Your expertise will enhance demand forecasting, inventory management, and strateg...
Reposted yesterday
Senior Financial Analyst (Operations)
$66K - $105K *
Help us optimize financial performance through advanced analysis and modeling. Collaborate with business leaders on budgeting, forecasting, and strategic initiatives, providing insights to drive reven...
Reposted 1 week ago
$120K - $145K *
Drive mobile engineering excellence by leading app development, mentoring engineers, and integrating AI solutions to enhance user experiences across iOS and Android platforms while collaborating with...
6 days ago
Member of Technical Staff, AI Researcher (New Stealth Startup)
$250K - $400K *
Shape the future of AI by designing evaluation frameworks and feedback systems that enhance model performance. Collaborate across teams to translate research into scalable solutions, driving impactful...
1 week ago
Palantir - Sales Capture Senior Manager
$178K - $213K *
Drive impactful technology sales by engaging with senior stakeholders, managing a $20M+ pipeline, and collaborating with ecosystem partners to close complex deals while enhancing client relationships...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.