Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Audience Activation Specialist
$80K - $95K *
Join a team that's redefining acquisition marketing by developing advanced segmentation strategies, optimizing campaigns, and enhancing customer engagement to drive conversion rates and maximize ROI...
Today
$110K - $130K *
Engineer critical electrical and mechanical systems for data centers, leading field support, troubleshooting, and reliability improvements while developing operational standards and mentoring teams to...
6 days ago
$240K - $270K *
Join a team that's driving enterprise growth by owning relationships and closing deals. Leverage your expertise to navigate complex sales cycles, build a self-sourced pipeline, and expand accounts whi...
3 days ago
Application Engineer (Technical Sales) - Defense
$108K - $181K *
Create impactful technical solutions in military electrification projects. Collaborate with defense clients and provide expertise throughout the proposal process, ensuring compliance and mission effec...
Reposted 1 week ago
Head of Technology & Data Partnerships
$195K - $270K *
Transform the technology and data partnership landscape by defining and executing a strategic vision that enhances product innovation, strengthens market positioning, and drives sustainable growth thr...
Yesterday
$110K - $130K *
Lead supplier quality initiatives to ensure product conformity and drive continuous improvement. Collaborate with cross-functional teams to establish quality standards, manage audits, and enhance supp...
Reposted 1 week ago
Senior Software Engineer, Enterprise AI
$199K - $210K *
Unlock potential by joining a dynamic team to design and develop scalable AI solutions. Collaborate across disciplines to transform complex challenges into impactful products, driving innovation and e...
4 days ago
$90K - $100K *
Unlock potential by delivering innovative robotic solutions, ensuring seamless integration and operational success for customers. Collaborate, troubleshoot, and enhance system performance while provid...
2 weeks ago
Project Engineer - High-Speed Balance
$80K - $95K *
Deliver hands-on expertise in balancing Steam and Gas Turbines, ensuring safety and quality while collaborating with teams to execute production plans and troubleshoot complex systems effectively...
6 days ago
Software Engineer - Full Stack & AI-Enabled Development
$95K - $115K *
Transform ideas into secure, scalable applications by collaborating with business users. Leverage modern AI tools and full-stack development skills to deliver innovative solutions in a fast-paced envi...
3 weeks ago
Enterprise AI Architecture Manager / Senior Manager
$87K - $293K *
Innovate with cutting-edge AI solutions, leading architecture for enterprise systems. Drive multi-agent designs and collaborate with clients to enhance business value while managing engineering teams...
1 week ago
$122K - $261K *
Elevate employee experiences by leading digital transformation initiatives, providing strategic guidance, and implementing scalable solutions across enterprise environments to enhance productivity and...
1 week ago
Software Engineer III - Full Stack, Angular, Java, AWS
$102K - $136K *
Empower your career by designing and delivering scalable software solutions in a dynamic environment. Collaborate with cross-functional teams to enhance healthcare supply chain products using modern t...
2 weeks ago
$92K - $115K *
Champion client performance by managing Meta ad campaigns, optimizing strategies, and crafting compelling direct-response content to enhance engagement and retention across multiple accounts...
Reposted 6 days ago
Site Inspector Lead (Data Center Manufacturing Quality)
$100K - $120K *
Empower quality assurance excellence by leading inspections across North America, ensuring critical infrastructure meets project standards. Collaborate with suppliers and teams to mitigate risks and d...
1 week ago
Digital Demand Generation Manager
$80K - $95K *
Join a dynamic team as you lead digital marketing initiatives, focusing on webinars and paid advertising to drive engagement and generate leads. Collaborate with stakeholders to optimize strategies an...
1 week ago
Lifecycle Acquisition Financial Analyst
$110K - $130K *
Empower strategic acquisition and financial management for complex programs, interfacing with senior executives and ensuring alignment with agency objectives. Lead lifecycle planning and enhance progr...
1 week ago
Technical Lead (Data Science and AI/ML)
$125K - $150K *
Empower teams by providing technical leadership in data science and AI/ML, driving enterprise data modernization initiatives. Collaborate with stakeholders to design and deliver impactful decision-mak...
3 weeks ago
Senior Software Engineer - Grafana Search & Storage | US | Remote
$154K - $185K *
Join our dynamic team to develop next-gen storage solutions, enhancing Grafana's App Platform. Collaborate on innovative features, drive projects from ideation to operations, and contribute to an open...
1 week ago
Staff Software Engineer, Applied AI
$160K - $200K *
Join a team that's redefining operational efficiency by architecting robust internal tools and applying AI to real-world challenges. You'll lead technical direction, drive impactful decisions, and enh...
1 week ago
$144K - $195K *
Elevate healthcare analytics by leading reporting initiatives that enhance patient care across 600+ facilities. Collaborate with stakeholders to implement innovative solutions and ensure compliance in...
3 days ago
Clinical Delivery Leader, CMU Outcomes
$111K - $167K *
Transform your career by leading clinical strategies and implementations, ensuring successful adoption of digital solutions while collaborating with diverse stakeholders to enhance patient safety and...
4 days ago
FinOps AI / ML Engineer Manager
$87K - $253K *
Unlock potential by leading innovative FinOps automation programs, guiding teams in cloud engineering and AI orchestration. Drive cost governance and operational excellence across multi-cloud environm...
Reposted 4 days ago
$124K - $155K *
Champion data-driven insights as you lead a multidisciplinary analytics team, driving client performance and strategic recommendations to enhance business growth and market competitiveness...
1 week ago
$120K - $145K *
Join a dynamic team to design and implement scalable data processing pipelines, enhancing data flow and enabling faster analysis. Collaborate with cross-functional teams to translate business needs in...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.