Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$101K - $145K *
Lead the charge in leveraging advanced data science techniques to solve complex business challenges, mentor junior team members, and drive effective risk management through innovative algorithms and d...
2 weeks ago
$150K - $180K *
Drive the technical design and delivery of innovative AI agent solutions, leading a team to ensure operational readiness and quality. Collaborate with stakeholders to define requirements and guide eng...
Reposted 4 weeks ago
$130K - $175K *
Empower financial analysis and project management in the utility sector. Lead cost-of-service studies, develop client relationships, and mentor junior staff while ensuring quality and timely delivery...
5 days ago
Senior Director, Partnerships Analytics
$193K - $340K *
Lead analytics initiatives to empower strategic decisions in a fast-growing agent business. Drive insights, build foundational data systems, and foster a high-performing team to enhance user experienc...
Reposted today
Enterprise Risk Management Data Analytics Lead
$156K - $181K *
Unlock potential by driving enterprise risk management through advanced analytics and reporting solutions. Collaborate with stakeholders to enhance decision-making and operational effectiveness while...
Today
Engineering Manager, Object Storage
$150K - $180K *
Lead a talented team in crafting a high-quality, scalable object storage product that enhances the developer experience, balancing technical execution with product thinking to drive meaningful improve...
Reposted 1 week ago
Associate Technical Architect - Data - USA
$125K - $150K *
Champion innovative data solutions by architecting scalable cloud data pipelines and lakes. Leverage deep financial services expertise to drive technical product management and ensure seamless data in...
Today
$80K - $95K *
Advance your career by driving impactful Paid Social strategies across platforms like Meta and TikTok. Collaborate with cross-functional teams to optimize campaigns, leverage data insights, and enhanc...
1 week ago
AI Conversation Design Senior Consultant
$130K - $200K *
Lead the charge in designing innovative AI conversational experiences, architecting multi-turn systems, and collaborating with clients to transform digital interactions across various platforms and ch...
Yesterday
AI Conversation Design Senior Consultant
$130K - $200K *
Lead the charge in designing innovative AI-driven conversational experiences, architecting multi-agent systems, and collaborating with clients to transform digital interactions across various platform...
Yesterday
$80K - $95K *
Join a team that's dedicated to driving financial excellence through detailed analysis, reporting, and strategic recommendations. Collaborate with leadership to enhance financial performance and suppo...
4 days ago
Lead, Enterprise Data & AI Governance
$100K - $135K *
Elevate your career by leading enterprise data and AI governance initiatives. Collaborate across teams to define frameworks, implement policies, and drive adoption of responsible AI practices, ensurin...
3 weeks ago
Senior Demand Generation Manager
$140K - $165K *
Lead comprehensive demand generation efforts by managing campaigns, events, and HubSpot systems to enhance pipeline efficiency. Influence strategy and execution for paid media, thereby driving measura...
Reposted yesterday
Senior Recruiter - AI, Data & Innovation
$86K - $101K *
Engage with senior leaders to strategically source and recruit top talent in AI, data, and innovation. Drive talent acquisition strategies, build diverse pipelines, and enhance candidate experiences w...
5 days ago
AI Delivery Engineer - AWS Bedrock
$135K - $220K *
Engage with clients to transform business challenges into AI solutions. Collaborate in a multidisciplinary team to develop prototypes and integrate AI applications using AWS services, ensuring quality...
Today
Senior Statistical Programmer/Analyst Consultant (Need solid oncology background) Remote in US
$110K - $130K *
Champion statistical programming excellence in oncology clinical trials. Lead programming activities, collaborate with cross-functional teams, and ensure high-quality deliverables from study start-up...
2 weeks ago
Senior Manager, AI Advisory and Open Source Program Office
$200K - $250K *
Unlock the potential of Open Source and AI governance by leading a multidisciplinary team to ensure compliance, drive best practices, and foster innovation across the enterprise, while collaborating w...
6 days ago
$144K - $184K *
Join an innovative engineering team to transform product delivery through AI-driven development, ensuring high standards and compliance while combining product, design, and engineering leadership acro...
Reposted 1 week ago
Software Engineer - (RPA/Computer Vision)
$80K - $95K *
Transform the healthcare landscape by developing intelligent automation solutions for Revenue Cycle Management. Leverage your Python expertise and computer vision skills to enhance efficiency and accu...
5 days ago
$150K - $180K *
Drive enterprise sales strategy for innovative agentic products, building relationships with key decision-makers. Collaborate with product and engineering teams to translate customer needs into compel...
2 weeks ago
Clinical AI Technical Integration Specialist
$110K - $130K *
Unlock potential by driving technical integration and validation for Ambient AI Scribe initiatives. Collaborate with clinical teams to enhance workflows, troubleshoot issues, and ensure operational re...
2 weeks ago
Senior Software Engineer, AI Platform
$187K - $220K *
Join a team that's shaping the future of AI in IT Operations. As a Senior Software Engineer, you'll design and build innovative platform capabilities, driving impactful solutions and collaborating dir...
4 weeks ago
$135K - $160K *
Unlock your potential as a Lead Data Software Engineer, driving innovative data solutions and leading cross-functional teams to enhance our data infrastructure and ensure scalability and performance a...
3 weeks ago
Technology Consulting Senior Principal
$122K - $292K *
Lead the charge in transforming technology investments into strategic business value. Drive client engagements, optimize financial management, and develop actionable insights to enhance organizational...
4 days ago
Senior Business Intelligence Analyst
$135K - $150K *
Join a team that's redefining business intelligence through Power BI. You'll develop impactful reports and dashboards, enhance client-facing platforms, and ensure data integrity while collaborating wi...
6 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.