Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$130K - $155K *
Drive innovative AI solutions by designing and deploying advanced models that tackle complex business challenges, influencing enterprise strategy and enhancing client outcomes through data-driven insi...
2 weeks ago
Compensation Analyst II - Remote
$78K - $131K *
Contribute to the development and administration of competitive compensation programs, ensuring alignment with organizational strategy. Lead projects and provide consultation to HR partners while main...
5 days ago
$120K - $130K *
Champion the modernization of data processes by designing and maintaining robust data pipelines in Azure. Collaborate with stakeholders to ensure accurate data integration and support enterprise data...
1 week ago
Group Director, Client Media Solutions
$175K - $200K *
Lead the charge in developing integrated media strategies and client partnerships across pharmaceutical and life sciences accounts, driving business growth and ensuring exceptional delivery and client...
2 weeks ago
Senior Product Manager | Applied AI
$135K - $160K *
Champion the vision and strategy for AI-powered products, driving their roadmap and delivery while mentoring peers. Leverage AI tools to enhance decision-making and product lifecycle management, ensur...
4 weeks ago
$95K - $115K *
Engineer customer reliability by providing expert technical support for IoT solutions. Collaborate with teams to resolve issues, enhance documentation, and gather feedback, ensuring a seamless custome...
1 week ago
Infrastructure Solutions Engineer
$136K - $170K *
Drive impactful infrastructure solutions by collaborating with engineering teams to resolve blockers, execute migrations, and develop tooling. Leverage your expertise to enhance platform adoption and...
2 weeks ago
Product Manager, New Content Initiatives and Analysis
$140K - $175K *
Transform investment research by evaluating and integrating diverse datasets, enhancing AI-driven workflows, and driving strategic content initiatives to elevate platform value and user experience...
1 week ago
$125K - $187K *
Transform energy efficiency initiatives by leading a skilled engineering team. Drive project execution, mentor talent, and enhance program delivery across multiple states, ensuring impactful cost savi...
1 week ago
Aviation Technology Program Engineer (Associate Principal, Aviation Technology Engineer)
$141K - $186K *
Transform aviation security by leading multidisciplinary teams, managing client relationships, and ensuring project success in airport technology systems. Leverage 8-10 years of experience to enhance...
3 weeks ago
Aviation Technology Program Engineer (Associate Principal, Aviation Technology Engineer)
$141K - $186K *
Elevate your career by leading technology and security engineering for major aviation projects. Collaborate with clients and multidisciplinary teams to ensure successful project delivery while enhanci...
3 weeks ago
$200K *
Lead the charge in building and scaling AI Data Operations, transforming emerging opportunities into commercially viable solutions. Drive strategy, partnerships, and operational excellence to support...
4 weeks ago
Senior Marketing Analytics Consultant
$100K - $125K *
Unlock potential by leveraging data to drive marketing strategies and insights. Collaborate with cross-functional teams to analyze customer behavior and quantify marketing impact, enhancing decision-m...
1 week ago
Sr. Software Engineer II (Tech Lead)
$114K - $191K *
Lead the charge in shaping high-impact SaaS solutions by driving technical strategy and empowering a high-performing engineering team. Collaborate across disciplines to foster innovation in a fast-pac...
Reposted 4 days ago
Senior Attack Engineer, External
$206K - $242K *
Transform external attack capabilities by developing scalable workflows and automating reconnaissance processes. Drive innovation in offensive security, mentor teammates, and contribute to a high-impa...
2 weeks ago
Senior Clinical Data Programmer (Python)
$110K - $130K *
Transform clinical data programming by developing scalable Python solutions, modernizing SAS workflows, and building reusable frameworks to enhance clinical trial data delivery and influence technolog...
4 days ago
$150K - $180K *
Shape the future of AI evaluation by leading rigorous methodologies, collaborating with engineers, and mentoring teams to ensure accurate assessments that drive product innovation and market standards...
1 week ago
$110K - $130K *
Unlock developer potential by creating engaging content, organizing events, and fostering community connections. Collaborate with cross-functional teams to enhance user experience and advocate for dev...
2 weeks ago
$119K - $179K *
Lead the charge in architecting FHIR-compliant data models to enhance clinical data integration and usability, supporting patient care and research initiatives across the organization...
4 weeks ago
$119K - $180K *
Lead the development of innovative web platforms, collaborating with cross-functional teams to enhance content management systems. Drive technical decisions and foster a culture of growth while ensuri...
2 weeks ago
Actuarial AI Transformation Consulting Director
$155K - $220K *
Drive innovation in actuarial functions by leveraging AI and advanced analytics. Lead high-impact initiatives that transform insights into actionable business strategies, enhancing decision-making and...
3 weeks ago
$135K - $165K *
Join a team that's shaping the future of data architecture by leading the design and delivery of unified customer data solutions within the Salesforce ecosystem, ensuring client success through innova...
3 weeks ago
Consulting Engineer - AI Networking & Fabric Architecture
$77K - $108K *
Innovate high-performance AI network fabrics for accelerated computing. Engage with clients to deliver tailored solutions, ensuring optimal configurations for GPU clusters and data-center infrastructu...
1 week ago
Environmental Consulting Project Director
$202K - $289K *
Champion growth in environmental services by leading business development, managing complex projects, and fostering client relationships in the power industry. Leverage your expertise to navigate regu...
1 week ago
$110K - $130K *
Lead the charge in transforming product vision into market success by leveraging customer insights, strategic positioning, and cross-functional collaboration to drive impactful go-to-market strategies...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.