Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Director of Client Experience, Lab Network
$125K - $160K *
Drive client success in our lab network by managing relationships, ensuring renewals, and identifying growth opportunities. Collaborate across teams to enhance processes and improve client experiences...
2 weeks ago
$190K - $267K *
Unlock potential by developing robust software solutions that enhance compliance and security programs. Collaborate across teams to automate processes, streamline workflows, and ensure timely risk man...
Today
$115K - $125K *
Champion the configuration of our Ascend 2.0 platform by leading spec negotiations and ensuring data quality for client onboarding. Collaborate cross-functionally, manage multiple implementations, and...
Reposted yesterday
$128K - $214K *
Champion user research strategies that shape digital experiences by turning data into actionable insights, collaborating across teams to enhance user engagement and optimize web performance globally...
Reposted 1 week ago
Director - Statistics - Lilly Regenerative Medicines
$193K - $308K *
Join a team that's redefining statistical leadership in clinical research. Drive innovative study designs, enhance drug development effectiveness, and influence critical decisions through data-driven...
2 weeks ago
$90K - $100K *
Join a team that's dedicated to ensuring sales compensation accuracy and integrity. You'll support deal desk operations and provide analytical insights, making a significant impact on revenue processe...
1 week ago
$110K - $130K *
Empower your career by joining a dynamic SRE team focused on scaling Cloud services. Drive reliability, performance, and efficiency while leveraging your engineering skills to enhance infrastructure a...
3 days ago
Integration Analyst Engineer (Remote)
$115K - $125K *
Empower your career by driving the integration and migration of data for a vital financial management system. Collaborate with experts to enhance system reliability and operational efficiency in a ful...
4 weeks ago
Director, Research & Insights, Quantitative
$95K - $115K *
Transform healthcare insights by leading end-to-end quantitative market research. Collaborate with pharmaceutical teams to design impactful studies, analyze data, and deliver actionable recommendation...
2 weeks ago
Director Search Strategy & Performance Marketing
$135K - $160K *
Pioneer in search strategy, driving optimization across paid, organic, and AI channels. This role collaborates with cross-functional teams to enhance visibility, engagement, and customer acquisition t...
Reposted 2 weeks ago
$110K - $130K *
Unlock potential by serving as a top-tier technical expert, mentoring peers, and resolving complex challenges in customer success. Drive scalable processes and enhance team capabilities while engaging...
Yesterday
Quality Automation Engineer (SDET)
$95K - $115K *
Elevate your career by leading software testing initiatives, defining test cases, and implementing automation solutions. Collaborate with teams to enhance quality engineering strategies and ensure com...
2 weeks ago
$150K - $165K *
Engage clients by driving revenue through consultative sales, building strong relationships with law firms and corporations. Leverage industry insights to anticipate needs and deliver tailored solutio...
2 weeks ago
$125K - $150K *
Grow your career with an innovative startup, driving strategic enterprise deals and cultivating key relationships with Fortune 1000 executives to showcase cutting-edge AI technology and deliver except...
Reposted today
Revenue Analytics Finance Manager
$90K - $167K *
Unlock potential by driving revenue insights and financial modeling, enhancing decision-making across finance and operations. Collaborate with stakeholders to refine processes and improve revenue reco...
4 days ago
$139K - $235K *
Lead the development of innovative CX solutions using AI tools, enhancing workflows and integrations across platforms. Collaborate with cross-functional teams to deliver production-quality software an...
Today
Senior Account Manager, Programmatic
$85K - $100K *
Lead the execution and optimization of programmatic campaigns, fostering client relationships and mentoring team members to achieve strategic goals and enhance performance in a collaborative environme...
2 weeks ago
$95K - $115K *
Unlock your potential by developing innovative software solutions using C#, .NET, and Azure. Collaborate with cross-functional teams to enhance business operations and drive technology initiatives tha...
5 days ago
$125K - $140K *
Elevate your career by designing and managing AWS environments, automating CI/CD, and ensuring robust application delivery. Collaborate with cross-functional teams for end-to-end ownership and enhance...
Reposted yesterday
$80K - $95K *
Lead the charge in complex data analysis and management initiatives, transforming insights into actionable recommendations that drive product portfolio decisions and business growth while mentoring ju...
6 days ago
Senior/Staff Software Engineer (Platform and Execution Model)
$180K - $240K *
Transform the future of distributed systems by designing and building robust platform components. Collaborate with teams to ensure reliability and scalability in mission-critical environments, driving...
3 weeks ago
$127K - $163K *
Empower the design and delivery of scalable data solutions on Google Cloud, leading a team to enhance operational excellence and drive strategic business outcomes through innovative data engineering p...
1 week ago
$80K - $95K *
Contribute to process improvements and technical support in manufacturing. Lead capital projects, enhance equipment efficiency, and collaborate with stakeholders to optimize operations while leveragin...
4 days ago
Software Engineer III - Developer Platform & AI Enablement
$102K - $136K *
Join a team that's transforming healthcare by developing essential tooling and AI capabilities for engineers. This role spans software development, architecture, and collaboration in an Agile environm...
Reposted 1 week ago
Senior Product Manager - Inference Platform
$228K - $285K *
Pioneer advancements in AI inference platforms, driving strategy and execution across cross-functional teams to enhance scalability and reliability for enterprise customers. Lead product initiatives f...
6 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.