Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Director, Engineering (AI Patient Engagement Platform)
$180K - $230K *
Join a dynamic team as you lead engineering efforts to develop an AI Patient Engagement Agent, transforming clinical trials by automating patient interactions and enhancing operational efficiency for...
3 weeks ago
Staff Product Manager, Measurement (Ads)
$181K - $214K *
Lead the charge in defining and executing on-platform measurement strategies, ensuring effective ad performance tracking and reporting across diverse ad formats while collaborating with engineering an...
Reposted 3 days ago
$80K - $95K *
Analyze complex model development and validation projects, leveraging your statistical expertise to drive performance management. Collaborate with senior managers and progress to a subject matter expe...
1 week ago
$80K - $95K *
Champion complex model development and validation across diverse projects. Leverage your statistical expertise to enhance performance management while collaborating with senior leaders and progressing...
1 week ago
$110K - $130K *
Elevate your career by leading SCADA design and engineering for high-voltage electrical power systems. Collaborate with a multi-disciplinary team to optimize substation projects, ensuring efficient ex...
Yesterday
$115K - $140K *
Join us to drive revenue growth by engaging senior finance leaders, executing full-cycle sales, and delivering tailored software solutions that address financial challenges and enhance operational eff...
1 week ago
Lead Data Engineer - Google Cloud & Azure Databricks (Kansas City)
$120K - $145K *
Accelerate progress at the forefront of data engineering by designing and implementing scalable data pipelines across multi-cloud environments, while mentoring a talented team and aligning technical s...
1 week ago
$80K - $128K *
Analyze and monitor security alerts, investigate threats, and enhance SOC processes. Collaborate with teams to ensure cybersecurity measures are effective, while documenting incidents and providing te...
1 week ago
$80K - $128K *
Elevate cybersecurity operations by monitoring threats, analyzing network traffic, and coordinating incident responses. Collaborate with teams to enhance security measures and mentor junior analysts w...
1 week ago
Senior Consultant - Data Platforms & Architecture
$103K - $154K *
Unlock advanced data solutions by leveraging Microsoft Azure and Power BI. Collaborate with teams to deliver high-quality analytics and reporting, while enhancing business intelligence capabilities th...
2 weeks ago
$100K - $120K *
Engage clients by driving the full sales cycle of AI solutions, converting leads and exploring growth opportunities while collaborating across teams to enhance client outcomes and product evolution...
Reposted 3 weeks ago
$175K - $218K *
Join a team that's redefining revenue growth through innovative ML solutions. As a Lead Data Scientist, you'll drive impactful monetization strategies for millions of users, collaborating across teams...
3 weeks ago
$75K - $158K *
Join a team that's dedicated to optimizing operations in a fast-paced environment. Support technical and functional stakeholders while ensuring seamless processing and troubleshooting across systems...
6 days ago
$229K - $330K *
Transform financial strategy for GTM operations, driving growth through data-driven insights and modernized processes. Collaborate with cross-functional teams to enhance performance, optimize investme...
3 weeks ago
$110K - $165K *
Unlock potential by designing and maintaining robust data pipelines and Power BI models to transform operational data into actionable insights for stakeholders, ensuring data integrity and performance...
Yesterday
Senior Account Manager, Adtech
$75K - $95K *
Empower innovation in mobile advertising by leveraging expertise in measurement and fraud mitigation. Collaborate with stakeholders to enhance adtech solutions and navigate the evolving landscape of d...
2 weeks ago
$130K - $155K *
Collaborate to design and develop scalable solutions for modern data platforms, utilizing Python and cloud technology. Drive innovation through AI-assisted tools, while building robust data pipelines...
Reposted 4 weeks ago
Associate Director, Strategy & Operations
$179K - $248K *
Lead the charge in operationalizing strategy and driving cross-division initiatives. Collaborate with senior stakeholders to enhance efficiency and client satisfaction in a fast-paced corporate travel...
4 weeks ago
Senior Director of Account Management
$150K - $180K *
Lead a dynamic account management team, driving strategic relationships with major health systems. Foster high-touch engagement, ensuring customer success and operational excellence while directly man...
3 weeks ago
$160K - $230K *
Elevate your career by owning the infrastructure and security of a multi-environment platform. Collaborate with leadership to build and operate systems that support critical government operations and...
Today
Account Executive - Enterprise SaaS | Workday, SAP & Coupa
$125K - $150K *
Join a dynamic team to drive enterprise sales within the Workday, SAP, or Coupa ecosystems. Leverage your relationships and expertise to navigate complex sales cycles, engage C-suite executives, and a...
2 weeks ago
Lead Electrical Engineer, Datacenter
$138K - $184K *
Lead the charge in designing resilient electrical systems for mission-critical facilities. Collaborate with teams to oversee full-cycle electrical design, ensuring high availability and operational ex...
Yesterday
$70K - $196K *
Lead the charge in developing scalable robotics solutions, tackling complex challenges in AI and engineering. Collaborate with experts to innovate and implement cutting-edge technologies for global in...
4 days ago
$80K - $95K *
Transform patient access by optimizing Epic Cadence workflows. Collaborate with clinical teams to enhance scheduling efficiency and support system improvements, ensuring seamless operations and superi...
1 week ago
Staff Information Security Engineer
$170K - $220K *
Drive innovation by safeguarding AI systems while implementing robust security measures. Collaborate with diverse teams to ensure efficient AI integration and risk management, balancing security requi...
Reposted today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.