Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Technical Commerce & AI Consultant | Agentic Commerce
$70K - $235K *
Unlock innovative AI-driven commerce solutions by designing and implementing multi-agent systems. Collaborate with clients to ensure scalable, secure deployments that align with business objectives an...
Reposted today
Staff Product Manager, Programmatic Ads
$165K - $339K *
Transform programmatic advertising by defining and scaling innovative products, collaborating across teams to enhance advertiser experiences while ensuring alignment with strategic business goals...
Reposted 3 weeks ago
$180K - $190K *
Empower our team to drive innovation by developing crucial AI tools that enhance operational efficiency. Oversee governance, training, and metrics to ensure impactful adoption across departments while...
Reposted 4 days ago
$185K - $260K *
Champion security excellence by designing and implementing robust software solutions. Collaborate with teams to enhance security practices, conduct code reviews, and respond to incidents, ensuring a s...
2 weeks ago
Senior Analyst - Strategy, Analytics & Reporting
$109K - $125K *
Unlock potential by transforming complex data into actionable insights that drive enterprise strategy and decision-making. Collaborate across teams to develop reporting tools and metrics that enhance...
2 days ago
$130K - $160K *
Drive the development of LLM-based agents, ensuring robust production systems, effective evaluation, and seamless integration with company data while maintaining security and operational excellence ac...
4 weeks ago
Databricks Analytics Consultant
$98K - $163K *
Explore innovative data solutions to enhance decision-making and operational efficiency for healthcare clients. Collaborate on analytics, machine learning, and application development to drive impactf...
1 week ago
Software Development Engineer II - Data Platform
$110K - $130K *
Join a team that's shaping the future of data platforms by building and operating high-scale distributed systems. Collaborate with engineers to enhance analytics capabilities and empower organizations...
1 week ago
$160K - $200K *
Shape the future of talent acquisition by driving full-cycle recruiting across commercial teams. Collaborate with leaders to build a high-performing workforce that aligns with our mission and values...
1 week ago
$131K - $237K *
Empower mission success by transforming complex data into actionable insights. Lead the design and operationalization of advanced data science capabilities, collaborating with cross-functional teams t...
2 weeks ago
Senior Data Analyst in St. Louis, MO
$114K - $221K *
Lead the charge in data-driven decision-making for application migration, analyzing complex datasets, ensuring data integrity, and presenting actionable insights to stakeholders within Agile framework...
Today
Senior Financial Analyst, FP&A
$90K - $120K *
Drive financial excellence by collaborating across teams to enhance planning and reporting processes. This role blends detailed analysis with strategic insight, offering visibility into key leadership...
Reposted 1 week ago
Machine Learning / AI Engineer
$115K - $158K *
Join a dynamic team to develop cutting-edge AI for audio experiences. You'll design, train, and optimize machine learning models, collaborating with engineers to enhance product capabilities while pus...
Yesterday
$84K - $105K *
Drive project success by managing client relationships and leading implementation strategies. Collaborate with teams to assess needs, develop plans, and ensure timely delivery while navigating challen...
1 week ago
$84K - $105K *
Deliver exceptional client engagement by managing project success, assessing needs, and developing strategic plans. Lead cross-functional teams to ensure timely and budget-compliant implementations wh...
3 weeks ago
Principal Backend Engineer, Enterpise Platform
$255K - $295K *
Lead the technical direction for foundational services, guiding architecture and execution across teams to enhance platform capabilities for customer and partner experiences. Mentor engineers and infl...
Today
Lifecycle Acquisition Analyst - Subject Matter Expert
$110K - $130K *
Join a team that's shaping strategic acquisition and program management for complex geospatial initiatives. Lead long-term planning, interface with senior executives, and ensure alignment with agency...
1 week ago
$120K - $150K *
Innovate as you guide Fortune 500 clients in leveraging AI solutions. Collaborate with sales teams, deliver dynamic presentations, and serve as trusted technical advisor to modernize legacy systems an...
Reposted 2 weeks ago
Principal Sales Applications Engineer
$128K - $188K *
Drive your career with impactful technical sales in the medical device sector. Lead customer engagements, identify new business opportunities, and collaborate with cross-functional teams to enhance pr...
2 weeks ago
$110K - $130K *
Oversee the design and development of clinical databases while ensuring project timelines and quality standards are met. Collaborate across teams to provide technical support and mentor team members...
Reposted 2 weeks ago
Manager, Customer Success Engineering
$124K - $210K *
Drive customer success by leading a team of engineers to enhance GitLab adoption, develop scalable enablement programs, and collaborate with cross-functional teams to achieve measurable business outco...
2 weeks ago
Sr. Staff Software Engineer, Cribl AI
$250K - $300K *
Shape the future of observability data by integrating cutting-edge AI into core products. Collaborate with engineers to solve real customer challenges while innovating and refining user experiences ac...
Reposted today
Responsible AI Engineering Senior Manager
$122K - $292K *
Join a team that's shaping the future of Responsible AI by leading global delivery teams, architecting production-grade AI solutions, and embedding ethical standards throughout the AI lifecycle to ens...
3 weeks ago
$88K - $115K *
Empower organizational change by analyzing stakeholder needs and implementing effective strategies. Collaborate with leadership and teams to enhance processes, ensuring smooth transitions and measurab...
Today
Management Analyst (Human Resources)
$80K - $95K *
Help us enhance federal human capital operations through independent analysis, strategic recommendations, and effective program delivery. Collaborate on data-driven insights to improve efficiency and...
Reposted 2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.