Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Full-Stack Engineer - Case Strategy
$120K - $145K *
Shape the future of healthcare by owning and optimizing AI systems. Design and deliver scalable ML solutions that transform operations, enhance decision-making, and create real-world impact across cri...
Reposted 3 weeks ago
Experienced QA Engineer with Hands-on Automation and AI Skills
$105K - $207K *
Lead the charge in quality assurance as you drive innovative testing solutions, ensuring excellence in custom technology implementations while collaborating with clients and cross-functional teams to...
Yesterday
Experienced QA Engineer with Hands-on Automation and AI Skills
$105K - $207K *
Elevate client success by leading innovative testing solutions in AI & Engineering. Collaborate with top professionals to enhance technology platforms, ensuring quality assurance and driving impactful...
Yesterday
$75K - $90K *
Elevate financial insights as a Senior Financial Analyst, partnering with leaders to drive strategic planning, budgeting, and reporting. Leverage your analytical skills to enhance operational performa...
1 week ago
Software Engineer 4/5 - Model Serving Systems, AI Platform
$466K - $500K+*
Unlock potential by developing scalable AI/ML model serving infrastructure. Collaborate cross-functionally to enhance performance and availability of high-traffic systems, driving innovation in a dyna...
5 days ago
$133K - $173K *
Shape the future of AI governance by designing frameworks and policies that ensure responsible innovation and effective risk management across the enterprise. Collaborate with cross-functional teams t...
1 week ago
Sr Staff Application Engineer - AI Enablement
$131K - $189K *
Lead the charge in enhancing data quality and integration across PLM systems. Oversee complex projects, mentor teams, and align technology initiatives with business goals to drive innovation and opera...
4 days ago
Forward Deployed Researcher - Data as a Service
$180K - $300K *
Partner with us to tackle complex data challenges and enhance frontier AI model performance. In this critical role, engage with leading AI labs to design innovative datasets and environments while tra...
Reposted 3 weeks ago
Senior Manager - Data Mining & Exploratory Intelligence
$93K - $154K *
Transform claims analysis by leveraging deep operational insights to identify patterns and anomalies. Collaborate with cross-functional teams to develop advanced data mining capabilities that enhance...
Today
$120K - $150K *
Innovate within a cutting-edge DataOps environment, ensuring the reliability and scalability of a Databricks-native data platform on Azure. Leverage AI for observability and pipeline management while...
6 days ago
$101K - $112K *
Lead the charge in managing complex projects within the Education portfolio, ensuring effective coordination across teams and stakeholders while driving impactful outcomes in higher education and appl...
1 week ago
$107K - $192K *
Lead the charge in transforming operational data into actionable insights that enhance sales and profits. Collaborate with cross-functional teams to drive measurable improvements and support strategic...
2 weeks ago
Business Data Analyst (Remote)
$100K - $140K *
Transform data into actionable insights by collaborating with leadership to analyze, visualize, and communicate findings. Leverage expertise in business intelligence tools to enhance decision-making f...
1 week ago
Lead Applied Scientist, Document Understanding
$147K - $274K *
Develop advanced document understanding systems to enhance legal content processing. Collaborate across teams to design, deploy, and evaluate models that drive measurable impact in legal, tax, and acc...
2 weeks ago
$180K *
Innovate your career as a Principal Data Engineer, designing cutting-edge data infrastructure and lakehouse solutions. Leverage modern AI tools to enhance performance and quality while collaborating w...
1 week ago
Enterprise AI Architecture Director
$122K - $338K *
Transform enterprise AI strategies by owning methodologies, technical perspectives, and asset portfolios. Collaborate with sales leadership and engage in high-stakes client interactions to drive impac...
1 week ago
$75K - $110K *
Unlock advanced analytics capabilities by leading data science initiatives that drive informed decision-making and operational efficiency in a regulated environment. Collaborate with stakeholders to d...
1 week ago
Senior Clinical Database Programmer - eCOA
$110K - $140K *
Champion the design and execution of eCOA studies, ensuring compliance and data integrity. Collaborate with cross-functional teams to deliver high-quality clinical outcomes while managing multiple pro...
6 days ago
$95K - $105K *
Join a dynamic team to provision and manage cloud environments, automate deployments, and ensure robust cloud security. Leverage your expertise in AWS or Azure and OpenShift to drive cloud migrations...
5 days ago
$95K - $105K *
Drive cloud infrastructure excellence by managing environments, automating deployments, and ensuring security. Collaborate on cloud migrations and capacity planning while producing essential documenta...
1 week ago
$77K - $94K *
Engage with clients by managing media services, developing integrated strategies, and ensuring campaign success. Collaborate with teams to drive innovative solutions and mentor junior members while ma...
2 weeks ago
Senior Lead Applied AI Scientist
$176K - $220K *
Elevate innovation by designing and implementing scalable AI solutions that drive business transformation. Collaborate with diverse teams to harness AI's potential and deliver measurable results while...
Reposted 4 days ago
$78K - $95K *
Join our team as a Data QA Analyst, where you'll ensure data migration quality across client onboarding. You'll standardize processes, validate data integrity, and collaborate with cross-functional te...
1 week ago
$145K - $190K *
Lead the design and evolution of scalable data architecture, providing technical leadership across teams to deliver reliable, secure, and cost-effective data solutions while shaping emerging capabilit...
3 weeks ago
$113K - $125K *
Drive product strategy and outcomes in a senior role, focusing on educational equity and data-driven impact. Collaborate with cross-functional teams to shape product direction, prioritize initiatives...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.