Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$125K - $150K *
Innovate AI solutions by developing tools and integrations that enhance workflows, drive efficiency, and empower teams. Collaborate across departments to implement scalable AI applications that delive...
6 days ago
Senior Analyst, GTM Systems & Tools (Customer Engineering)
$132K - $180K *
Drive impactful GTM systems strategy by optimizing processes and technology. Collaborate with cross-functional teams to enhance customer engineering workflows, ensuring alignment and continuous improv...
4 weeks ago
$110K - $130K *
Elevate your career by leading structural and finite element analyses of turbomachinery components. Collaborate with engineers to develop methodologies, support design evaluations, and enhance analyti...
Yesterday
$91K - $118K *
Lead the development and enhancement of critical software applications, ensuring performance and stability while collaborating with cross-functional teams to deliver market-driven solutions and suppor...
2 days ago
$90K - $105K *
Join a team that's dedicated to enhancing system reliability and performance for critical defense projects. Leverage your engineering expertise to implement best practices and drive data-driven improv...
3 weeks ago
$80K - $95K *
Engage in complex actuarial projects, analyzing risk contracts and training junior staff. Collaborate on pricing and management reports to support innovative capitation initiatives, fostering a dynami...
4 days ago
$165K - $180K *
Empower G&A operations by leading AI-driven transformations, enhancing workflows, and automating processes. Collaborate across teams to prototype solutions, ensuring efficiency and reliability in syst...
3 days ago
Client Strategy Manager, Measurement
$90K - $100K *
Drive your career forward by delivering actionable insights and strategies that enhance client media performance. Collaborate with cross-functional teams to craft compelling narratives and optimize me...
1 week ago
$180K - $200K *
Transform our data landscape by leading the end-to-end data platform, modernizing architecture, and empowering analytics teams to deliver trusted insights across the organization. Drive innovation wit...
1 week ago
$53K - $110K *
Unlock potential by leveraging data analysis to support public health initiatives. Collaborate on quantitative and qualitative evaluations, ensuring data integrity and contributing to impactful progra...
2 weeks ago
Business Analyst, Service Logistics
$95K - $115K *
Drive logistics optimization and cost reduction initiatives across global service operations, enhancing efficiency and performance in transportation and network design while collaborating with cross-f...
Yesterday
Engineering Manager, Partner Integrations
$225K - $265K *
Drive the development of seamless integrations for security platforms, leading a team to deliver high-quality, reliable products that enhance customer security stacks and ensure compatibility with evo...
1 week ago
Director - Data, Analytics & AI
$160K - $175K *
Elevate your career by leading data, analytics, and AI initiatives that drive strategic decision-making and operational excellence. Shape the future of our data ecosystem while collaborating with seni...
3 weeks ago
People Systems, Analytics, and AI Manager
$103K - $142K *
Transform workforce insights into actionable strategies by leveraging HR systems and analytics. Collaborate with cross-functional teams to enhance decision-making through compelling data visualization...
1 week ago
FinOps AI / ML Engineer Assoc Director
$163K - $413K *
Drive innovation by leading cloud engineering and FinOps automation initiatives. Leverage your expertise in agentic AI to deliver scalable solutions, optimize multi-cloud environments, and create exec...
Reposted 4 days ago
$110K - $130K *
Join a team that's dedicated to advancing clinical research through statistical expertise. Collaborate with medical professionals to design, analyze, and report on clinical studies, ensuring complianc...
1 week ago
Senior Market Research Analyst - International Development & AI
$70K - $95K *
Join a team that's shaping the future of AI in international development. Lead market research initiatives to identify opportunities, analyze trends, and provide strategic insights that drive business...
3 days ago
Manager, Media & Shopper Analytics
$109K - $135K *
Lead measurement and optimization of media and shopper marketing investments. Collaborate with cross-functional teams to translate data into actionable insights that enhance marketing performance and...
1 week ago
Senior Software Engineer II - LLM Observability
$183K - $206K *
Transform AI observability by developing end-to-end capabilities, architecting data models, and collaborating with cross-functional teams to enhance user workflows and insights into agent performance...
2 weeks ago
Scaled Customer Success Manager - Ads
$85K - $90K *
Empower customers through innovative strategies and data insights in digital advertising. Establish scaled success and deep relationships within the Ads portfolio, setting new standards for retention...
Reposted 4 days ago
$150K - $200K *
Develop and maintain robust data pipelines and models, collaborating with cross-functional teams to enhance data practices and ensure quality. Drive modernization efforts in data engineering, optimizi...
1 week ago
Account Executive, New Business
$100K - $135K *
Tackle the full sales cycle by winning new logos and expanding accounts. Drive pipeline growth through outbound prospecting and inbound leads, while shaping go-to-market strategies in a dynamic, remot...
6 days ago
$75K - $95K *
Join a team that's driving innovation in mobile advertising by managing fraud mitigation and partner relationships. Leverage your expertise in advertising measurement to navigate the dynamic landscape...
4 days ago
$120K - $145K *
Help us drive technical strategy and solutions for enterprise clients, addressing security challenges and delivering impactful demonstrations. Collaborate with cross-functional teams to translate comp...
Today
$80K - $95K *
Shape the future of pricing strategy by analyzing proposals, developing cost models, and ensuring compliance with federal regulations. Collaborate with cross-functional teams to enhance competitive po...
Reposted 4 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.