Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$150K - $200K *
Innovate robust ML infrastructure to enhance AI capabilities, ensuring seamless model deployment and performance. Collaborate with teams to streamline processes and drive impactful ML systems from res...
2 weeks ago
$82K - $137K *
Transform business insights into actionable data solutions by collaborating with stakeholders, analyzing data quality, and ensuring effective integration of analytical products to drive operational ef...
Reposted 4 days ago
$145K - $185K *
Lead and inspire engineering teams to deliver high-quality digital products, ensuring alignment with business priorities while fostering a culture of collaboration and continuous improvement in a dyna...
6 days ago
$149K - $224K *
Drive analytics excellence by leading a team to deliver impactful insights, enhance reporting capabilities, and support strategic decision-making across diverse business functions. Foster collaboratio...
1 week ago
Senior Data Analyst, Network Optimization
$110K - $130K *
Elevate data-driven decision-making by analyzing clinician networks to optimize patient care. Collaborate with cross-functional teams to enhance operational efficiency and improve healthcare outcomes...
2 weeks ago
$105K - $202K *
Create innovative AI-powered healthcare products by transforming complex workflows into intuitive applications. Collaborate with cross-functional teams to deliver impactful user experiences and own fe...
3 weeks ago
Senior SAS/Python Model Validation and Modernization Developer
$85K - $95K *
Elevate your career by validating and modernizing statistical models using SAS and Python. Collaborate with analysts and stakeholders to enhance analytical systems and ensure accuracy in mission-criti...
1 week ago
Senior Data Scientist, Systems Performance
$149K - $198K *
Elevate your career by leading data-driven evaluation methodologies for autonomous systems. Collaborate with cross-functional teams to ensure performance metrics align with safety standards, driving i...
3 weeks ago
$100K - $130K *
Unlock your potential as a Senior Financial Analyst, driving financial insights and models to support growth. Collaborate across teams to enhance forecasting accuracy and optimize performance, playing...
4 weeks ago
Senior Software Engineer – Identity Resolution
$130K - $155K *
Elevate your career by designing and developing high-scale Identity Resolution systems. Collaborate with cross-functional teams to create reliable, secure, and high-performance solutions that link and...
Today
Knowledge Engineering Manager / Senior Manager
$94K - $293K *
Join a dynamic team as you lead industry-specific knowledge engineering projects, designing ontologies and managing data lifecycles. Collaborate with clients to deliver innovative AI solutions that dr...
1 week ago
Senior AI Product Engineer, Fullstack
$125K - $225K *
Unlock innovation by building scalable, user-centric applications in TypeScript and React. Collaborate with engineering teams to enhance AI-driven solutions, ensuring top performance in ML observabili...
Reposted 4 days ago
Community Engagement Manager, Data Centers (Indiana & Kentucky)
$265K - $295K *
Lead the charge in community engagement, fostering trusted relationships with local stakeholders to ensure Anthropic's infrastructure projects benefit Indiana and Kentucky communities throughout their...
2 weeks ago
$150K - $180K *
Transform enterprise AI solutions by designing and implementing Multi-Agentic AI architectures. Leverage expertise in Generative AI, cloud technologies, and governance to lead projects from proof of c...
3 weeks ago
Sr. DataOps Engineer, Data Platform
$130K - $160K *
Transform data operations by leading our Snowflake platform migration, ensuring security, reliability, and cost efficiency while collaborating across teams to standardize practices and enhance data ma...
1 week ago
$150K - $180K *
Unlock potential by leading technical vision and mentoring engineers. Drive modernization and collaboration across teams to build resilient, scalable infrastructure while fostering a high-performance...
5 days ago
$147K - $217K *
Transform your career by leading innovative analytics in life sciences. Drive impactful strategies, mentor teams, and collaborate with clients to enhance marketing measurement and insights, all while...
3 weeks ago
$147K - $217K *
Lead transformative analytics initiatives in life sciences, driving innovation and client success. Mentor teams, enhance measurement standards, and collaborate cross-functionally to deliver actionable...
3 weeks ago
Audit Policy Analyst, Post-Acute Services
$80K - $95K *
Innovate post-acute payment integrity by developing and optimizing audit concepts for DME, home health, and infusion therapy claims. Collaborate cross-functionally to ensure compliance and enhance ope...
1 week ago
$147K - $217K *
Transform life sciences analytics by leading innovative measurement strategies, mentoring teams, and advising clients. Drive impactful insights and foster collaboration across disciplines to enhance m...
3 weeks ago
Senior Architect - Data Processing Systems, Analytics and Data Intelligence
$184K - $356K *
Transform data processing architectures by optimizing performance and efficiency. Collaborate with diverse teams to enhance user experiences and drive innovation in hardware-software co-design for cut...
Reposted 2 weeks ago
Global Head of Customer Success Engineering
$242K - $285K *
Transform the customer success landscape by leading technical teams, driving integration health, and enhancing revenue through strategic partnerships and innovative solutions in the programmatic ecosy...
4 days ago
$160K - $280K *
Join us to architect and build a cutting-edge web platform, driving marketing innovation through AI agents. Own technical decisions, enhance user experiences, and ensure seamless integration with our...
3 weeks ago
$80K - $100K *
Unlock your potential by contributing to enterprise EDI and integration projects. Collaborate with experienced engineers to design, implement, and optimize solutions, enhancing customer satisfaction a...
5 days ago
$170K - $200K *
Transform customer experiences by providing technical expertise and solutions. Collaborate with sales and engineering teams to deliver impactful product demonstrations and address technical challenges...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.