Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$130K - $155K *
Empower your career by leading DevOps initiatives, optimizing cloud infrastructure, and driving Agile practices. Collaborate with cross-functional teams to enhance scalability, security, and cost effi...
Today
$199K - $276K *
Drive enhancements to our unsecured underwriting models through rigorous research and experimentation. Collaborate with engineering teams to translate findings into scalable solutions that improve cre...
2 weeks ago
Lease Connectivity Engineer, Data Center Infrastructure
$120K - $145K *
Join a dynamic team to lead connectivity projects for leased data centers, ensuring compliance with standards and managing cross-functional collaboration from site assessment to operational handoff. D...
1 week ago
$160K - $180K *
Transform digital healthcare services by designing and deploying scalable machine learning models. Collaborate with cross-functional teams to enhance predictive capabilities and ensure compliance with...
6 days ago
$90K - $115K *
Partner with us to enhance client engagement and product success by leveraging your analytical skills and industry insights. Collaborate cross-functionally to drive improvements and support user adopt...
1 week ago
Senior Engineering Manager, Clients Team
$242K - $275K *
Lead the charge in developing and deploying robust containerized software, manage CI/CD workflows, and grow a cohesive engineering team to enhance customer security operations and software delivery ac...
Reposted 4 weeks ago
Senior GTM Demand Programs and Analytics Manager
$120K - $140K *
Transform your career by driving impactful sales playbooks and incentive programs. Leverage Salesforce, SQL, and AI tools to automate processes and enhance pipeline generation in a collaborative, glob...
1 week ago
$100K - $125K *
Champion data engineering excellence by designing and maintaining robust data pipelines and analytics solutions. Collaborate with stakeholders to enhance data quality and support enterprise-level data...
6 days ago
Analyst, Financial Planning & Analysis
$108K - $148K *
Join us as a Senior FP&A Analyst to drive financial planning, reporting, and forecasting. Collaborate across teams to optimize spending and enhance our financial systems, leveraging AI for insights th...
3 weeks ago
$104K - $156K *
Join us to architect innovative financial systems, leading greenfield projects that enhance data management and analytics. Collaborate across teams to implement your vision and drive impactful solutio...
5 days ago
$80K - $95K *
Optimize energy solutions by leading technical projects, conducting site surveys, and collaborating with teams to deliver innovative, cost-effective strategies that enhance facility performance and su...
1 week ago
$120K - $145K *
Empower clinical trial design by architecting robust data infrastructures that streamline insights extraction from diverse clinical documents, enhancing decision-making through advanced data pipelines...
1 week ago
Staff Software Development Engineer - Data Analytics
$106K - $213K *
Elevate digital engineering by designing and implementing scalable software solutions, collaborating with cross-functional teams, and driving innovation in data analytics projects to meet business obj...
Reposted 2 days ago
$90K - $137K *
Unlock your potential as you drive secure automation for cloud migrations, developing infrastructure as code and CI/CD pipelines. Collaborate with teams to enhance processes and ensure compliance whil...
5 days ago
$270K - $300K *
Elevate your career by owning a territory for enterprise accounts, driving complex sales cycles, and building AI solutions. Collaborate with cross-functional teams to deliver value and scale innovativ...
3 days ago
$85K - $165K *
Champion safety in innovative nuclear fuel recycling by evaluating hazards, developing safety documents, and ensuring compliance with regulations. Collaborate in a dynamic team to enhance safety measu...
4 weeks ago
Manager of Data Analysis for Lab Production Support, Extended-Hours Support (ExHS)
$140K - $175K *
Optimize data analytics support for lab production operations by leading a dedicated team in a dynamic environment. Drive innovation, ensure compliance, and enhance operational effectiveness while mak...
Reposted yesterday
Senior Knowledge Graph Engineer
$120K - $145K *
Transform healthcare data by designing and implementing scalable knowledge graph solutions. Collaborate with cross-functional teams to ensure robust technical implementations and optimize graph querie...
2 weeks ago
$135K - $160K *
Empower our data platform by designing, building, and operating core capabilities. Collaborate with teams to enhance ingestion, storage, and API functionalities, ensuring scalability and resilience wh...
3 weeks ago
Advisor, Competitive Intelligence – Inside-the-Data-Center Technologies
$114K - $182K *
Analyze competitive landscapes in ITDC technologies, providing strategic insights and support across functions to enhance market positioning and respond to emerging threats effectively...
1 week ago
$66K - $114K *
Champion the analysis and development of actuarial data to support Medicaid pricing. Collaborate with teams to refine models and ensure data accuracy, while gaining valuable experience in a dynamic, h...
3 weeks ago
$70K - $205K *
Champion complex digital forensic investigations and tool development, leveraging AI to enhance workflows. Collaborate with clients and teams to deliver actionable insights and scalable solutions acro...
Yesterday
$174K - $250K *
Drive your career forward by partnering with executives to shape AI strategies, lead complex architecture discussions, and deliver tailored solutions that enhance enterprise AI ecosystems and revenue...
5 days ago
Staff Data Scientist / Technical Lead (Full-Stack / Production ML)
$160K - $170K *
Lead a high-output data science team, driving end-to-end project delivery and technical direction. Engage deeply in data engineering, governance, and production model delivery while collaborating with...
3 weeks ago
$120K - $145K *
Transform the future of AI systems by building robust data pipelines and APIs. Collaborate with Product to refine specifications and enhance user experience, ensuring high-quality delivery and continu...
4 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.