Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$80K - $155K *
Join a team that's redefining energy solutions by designing innovative fluid and power systems. As a Process Engineer, you'll drive the development and optimization of cutting-edge technologies in a f...
2 weeks ago
$68K - $143K *
Support audit and compliance efforts for DoD financial systems, ensuring adherence to GAGAS and federal standards. Collaborate with stakeholders to enhance internal controls and audit readiness, drivi...
6 days ago
$120K - $145K *
Lead the charge in architecting and automating secure CI/CD pipelines and cloud infrastructure, ensuring compliance and resilience while delivering high-quality software through expert DevSecOps pract...
Yesterday
$140K - $185K *
Elevate your career by managing a dynamic data engineering team, shaping scalable data pipelines, and driving innovative data solutions to enhance enterprise data strategies and execution efficiency a...
Reposted 1 week ago
Manager, Marketing Analytics (Channel & Partner Performance)
$124K - $143K *
Unlock insights as a Marketing Analytics Manager, driving data analysis across channels. Collaborate with teams to enhance reporting, measurement, and performance evaluation, while mentoring analysts...
6 days ago
Laboratory Data Strategy & Architecture Lead
$156K - $166K *
Champion laboratory data strategy and architecture for a transformative pharmaceutical initiative. Lead data governance, mapping, and migration planning while collaborating with cross-functional teams...
Yesterday
$150K - $184K *
Lead the charge in enhancing platform security and infrastructure as a Senior Software Engineer. Utilize your Python expertise and SRE mindset to drive critical improvements, mentor teammates, and ens...
6 days ago
AI Services Lead - Client Services
$130K - $160K *
Drive AI transformation by leading client engagements, shaping strategies, and ensuring successful delivery. Build trusted relationships with stakeholders, oversee project execution, and mentor teams...
3 weeks ago
$95K - $115K *
Join a team that's dedicated to enhancing application performance through expert Dynatrace monitoring. Collaborate with IT professionals to analyze, troubleshoot, and optimize application performance...
3 weeks ago
$90K - $110K *
Transform application performance monitoring by leveraging your Dynatrace expertise. Collaborate with cross-functional teams to analyze data, troubleshoot issues, and implement solutions that enhance...
3 weeks ago
Front-End AI Engineer: Agentic AI Studio & Agentic AI as a Service Specialist
$70K - $205K *
Develop intuitive, user-friendly interfaces for advanced AI products, enhancing user experiences across various platforms. Collaborate with teams to create engaging, no-code solutions that simplify AI...
1 week ago
Data and Analytics Integration Specialist II
$80K - $95K *
Unlock the potential of data by designing integrations and analytics solutions that empower businesses to make informed decisions. Collaborate with clients and leverage modern technologies to transfor...
2 weeks ago
Lead Advisory Consultant, AI Governance
$125K - $150K *
Join a team that's redefining AI governance by developing frameworks and strategies that address enterprise needs while balancing risk and value for optimal outcomes...
Reposted today
$182K - $252K *
Champion data-driven decision-making by leveraging deep analytics expertise to guide product, marketing, and finance leaders. Drive strategic insights and build innovative tools that enhance business...
4 weeks ago
Software Engineer - Data Platform (R37)
$105K - $202K *
Engineer robust data platforms by designing scalable pipelines and APIs that support AI-driven healthcare applications, ensuring high performance, security, and operational excellence in a collaborati...
Reposted today
$150K - $185K *
Lead the development of innovative AI products that empower job seekers with evidence-based coaching and actionable insights, while collaborating closely with cross-functional teams to shape impactful...
3 weeks ago
Senior AI Engineer (Automation)
$120K - $180K *
Unlock potential by designing and deploying AI-driven automation systems that enhance logistics workflows. Collaborate across teams to transform complex processes into efficient, reliable solutions, e...
Yesterday
$110K - $130K *
Transform the cybersecurity landscape by driving revenue growth and building strong customer relationships in the mid-market segment. Leverage consultative selling and AI-driven solutions to engage te...
1 week ago
Director, BI & Data Engineering
$165K - $195K *
Lead the charge in developing and managing a robust Enterprise Data Warehouse on Databricks. Drive BI solutions, mentor a team, and ensure data quality while collaborating across departments to enhanc...
4 days ago
Senior Financial Analyst, Corporate FP&A
$115K - $151K *
Advance your career by leading financial reporting and forecasting efforts. Collaborate across departments to analyze data, streamline processes, and support strategic planning in a dynamic, high-grow...
1 week ago
$110K - $130K *
Transform your career by leading full-cycle recruiting for GTM roles. Collaborate with executives to define hiring standards, build strong talent pipelines, and drive strategic hiring initiatives in a...
2 weeks ago
Senior Software Engineer, Metrics and Evaluation - Autonomous Vehicles
$184K - $356K *
Develop metrics and evaluation methodologies to enhance Autonomous Vehicle software. Collaborate across teams to innovate testing strategies and deliver data-driven insights, driving forward cutting-e...
Reposted 2 weeks ago
Staff Pre-Sales Solutions Engineer
$140K - $200K *
Elevate enterprise solutions by leading complex technical evaluations, crafting innovative demos, and collaborating with senior stakeholders to drive AI adoption and business outcomes. Your expertise...
Reposted yesterday
Sr. Sustainability Engineer - Radiopharmaceutical Manufacturing
$110K - $130K *
Innovate your career with a key role supporting the global launch and technical operations of radiopharmaceuticals, driving compliance, quality initiatives, and collaboration with CDMOs while leading...
Reposted 2 weeks ago
$101K - $152K *
Champion innovative data solutions by designing and implementing Azure-based platforms. Engage in hands-on engineering to build reliable, scalable data pipelines and secure network architectures, ensu...
Today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.