Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$180K - $200K *

Deliver innovative backend solutions that enhance integrations and streamline security workflows. Collaborate with experts to build reliable services, ensuring seamless connectivity and improved inves...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$105K - $167K *

Lead the charge in designing and optimizing AI platform architectures, ensuring reliability and performance at enterprise scale. Collaborate with cross-functional teams to implement best practices and...

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $165K *

Analyze complex data from multiple sources to derive actionable insights that drive client success. Collaborate closely with cross-functional teams to create reports and recommendations tailored to cl...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$160K - $170K *

Elevate data engineering excellence by designing and implementing complex data solutions, mentoring engineers, and collaborating across teams to drive impactful data initiatives and architectural inno...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$91K - $118K *

Accelerate your career by driving technical solutions and proposals for engineered equipment. Collaborate with sales and engineering teams to ensure customer satisfaction and secure new business oppor...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$240K - $270K *

Champion advanced analytics to drive strategic insights and business growth. Lead a hands-on team, collaborating with cross-functional partners to enhance product performance, retention, and decision...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Food & Beverages

$118K - $166K *

Unlock potential by leveraging data science and AI to drive innovative solutions in marketing and commercial strategies, collaborating with cross-functional teams to transform complex challenges into...

4 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$190K - $267K *

Transform safety enforcement through data science by developing models and systems that detect and mitigate abuse. Collaborate across teams to translate policies into actionable insights, ensuring eff...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$200K - $270K *

Join a team pioneering AI/ML platform engineering, enhancing scalable infrastructure to empower scientific innovation. Shape the future of distributed systems and MLOps, collaborating across teams to...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$170K - $272K *

Advance your career by leading the development of scalable ML systems that drive impactful business outcomes through data science innovation and collaboration with cross-functional teams...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$130K - $242K *

Lead advanced analytics initiatives to enhance MAU insights, driving growth through experimentation and causal inference. Collaborate across teams to establish standards and leverage AI for scalable s...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$90K - $110K *

Join a team that's dedicated to enhancing HR data integration. Leverage your Workday expertise to design, implement, and maintain seamless connections between systems, ensuring data integrity and perf...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Develop and implement MLOps strategy for enterprise-grade ML systems, driving model lifecycle management. Collaborate with teams to design scalable pipelines and ensure high reliability across ML solu...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Innovate and drive AI agent development for clinical trial platforms, integrating LLMs through the .NET stack. Engage in hands-on engineering to deliver end-to-end AI features, enhancing patient-centr...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Transform the future of marketing by designing and deploying AI-driven growth systems. This hands-on role merges engineering and marketing to enhance customer engagement and streamline operations thro...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$150K - $180K *

Architect scalable Generative AI solutions using AWS tools, focusing on LLMs, RAG, and agent-based workflows. Collaborate with teams to ensure performance and cost efficiency while guiding implementat...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Drive the transformation of AI solutions by developing, deploying, and optimizing machine learning models. Collaborate with stakeholders to create innovative applications that enhance patient care whi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$175K - $195K *

Lead the charge in shaping enterprise data architecture, ensuring scalable, secure access across systems. Collaborate with engineering teams to deliver impactful data solutions that drive business val...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $180K *

Drive the modernization of Veterans Benefits Administration claims processing by designing and optimizing scalable data pipelines and solutions, ensuring efficient data integration and analytics for i...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$155K - $410K *

Unlock potential by leading AI and Machine Learning strategies to transform data into insights. Collaborate with clients and teams to drive business growth, ensuring quality solutions while mentoring...

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Legal & Accounting

$155K - $410K *

Shape the future of AI and data-driven solutions; lead innovative projects, mentor teams, and work with executives to transform insights into action, driving business growth in a dynamic environment w...

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Legal & Accounting

$102K - $190K *

Innovate data management processes by leading the development of robust data pipelines, ensuring high-quality data for analytics and reporting. Collaborate with cross-functional teams to enhance data...

Missouri, USRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Healthcare

$172K - $203K *

Elevate women's health outcomes by developing advanced machine learning models. Lead projects, mentor junior team members, and collaborate with cross-functional teams to drive innovation and commercia...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$92K - $110K *

Deliver strategic leadership and operational oversight to enhance decision-making processes within the Veterans Health Administration's EHRM, ensuring effective collaboration and communication across...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$171K - $190K *

Unlock potential by leading the design and implementation of scalable data platforms. Drive innovation in cloud data architecture and pipeline automation, collaborating across teams to deliver impactf...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.