Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$232K - $325K *

Empower innovation by serving as a leading expert in relevance evaluation. Collaborate to enhance ranking and recommendation systems, driving product strategy through rigorous analysis and shaping the...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Media

$120K - $145K *

Drive impactful digital media strategies by leading insights and innovation. Collaborate with clients to optimize media investments, manage a talented team, and present actionable insights that enhanc...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$500K+*

Lead the charge in developing a next-gen AI/ML serving and inference platform. Collaborate with cross-functional teams to architect scalable solutions that empower ML practitioners across diverse doma...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Hospitality & Recreation

$153K - $213K *

Drive efficiency by automating internal processes, enhancing productivity across teams. Collaborate with stakeholders to identify bottlenecks, implement AI solutions, and ensure measurable impact on w...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Pioneer data-driven decision-making by analyzing operational metrics and financial performance. Collaborate with leadership to enhance efficiency and drive continuous improvement in a fast-paced manuf...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$180K - $195K *

Drive impactful data science initiatives by building and operating ML systems. Manage end-to-end processes from modeling to evaluation, while mentoring a lean team and collaborating across departments...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$180K - $225K *

Lead the charge in transforming AI strategies into impactful solutions for revenue teams, collaborating closely with GTM leaders to drive innovation and measurable outcomes while enhancing engineering...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Take ownership of revenue modeling and forecasting, leveraging AI to automate processes and enhance reporting accuracy. Collaborate across functions to drive financial insights and support strategic d...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Business Services

$85K - $161K *

Elevate enterprise AI solutions by deploying, securing, and scaling AI assistants. Collaborate with clients to ensure readiness and optimize their AI journey from experimentation to production, enhanc...

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $145K *

Lead the charge in advancing AI applications in healthcare by developing intelligent agents that uncover financial opportunities within complex datasets, transforming manual analyses into scalable wor...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$77K - $176K *

Empower your career as a senior platform engineer, leveraging cloud technologies to enhance data environments. Collaborate with cross-functional teams to drive strategy, design, and implementation of...

5 days ago

  •   5 - 7 years exp.  •   Business Services

$129K - $177K *

Lead the charge in designing and delivering AI capabilities for a platform, integrating advanced workflows and intelligent analysis while actively contributing to production code and managing a small...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $185K *

Optimize product performance through data-driven insights, collaborating with cross-functional teams to define metrics, analyze customer behavior, and support strategic planning for impactful product...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Join a team that's redefining data solutions by leading the Data Products & Engineering department, shaping cutting-edge data architectures and innovative client-facing analytics solutions that drive...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Transform the future of power management by architecting data solutions that integrate telemetry, financials, and operational insights into a cohesive digital twin, enhancing decision-making across th...

3 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$178K - $294K *

Join a team that's redefining data engineering and analytics. Lead strategy, architecture, and execution of scalable data solutions while mentoring professionals and driving business outcomes through...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$192K - $202K *

Lead the technical roadmap and modernize data solutions infrastructure, enhancing off-platform integrations and measurement capabilities while driving AI-first engineering initiatives and cross-team c...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$111K - $167K *

Join a dynamic team as a strategic analytics partner, driving insights and performance improvements across revenue cycle operations. Collaborate with leaders to define KPIs, analyze data, and create i...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$313K - $365K *

Unlock potential by shaping the future of consumer insights through advanced data science. Lead measurement and modeling strategies to enhance user engagement and community dynamics, driving impactful...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$125K *

Engage with clients by leveraging data analysis and technical expertise to drive revenue growth. Collaborate with sales teams to ensure data accuracy and create tailored solutions, enhancing customer...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$180K - $200K *

Deliver innovative backend solutions that enhance integrations and streamline security workflows. Collaborate with experts to build reliable services, ensuring seamless connectivity and improved inves...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$105K - $167K *

Lead the charge in designing and optimizing AI platform architectures, ensuring reliability and performance at enterprise scale. Collaborate with cross-functional teams to implement best practices and...

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $165K *

Analyze complex data from multiple sources to derive actionable insights that drive client success. Collaborate closely with cross-functional teams to create reports and recommendations tailored to cl...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$160K - $170K *

Elevate data engineering excellence by designing and implementing complex data solutions, mentoring engineers, and collaborating across teams to drive impactful data initiatives and architectural inno...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$91K - $118K *

Accelerate your career by driving technical solutions and proposals for engineered equipment. Collaborate with sales and engineering teams to ensure customer satisfaction and secure new business oppor...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.