Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$115K - $143K *

Unlock the potential of data by architecting scalable pipelines and driving analytics initiatives, mentoring engineers, and collaborating with cross-functional teams to enhance our data solutions in a...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $110K *

Discover a dynamic role where you'll enhance customer search experiences and backend systems. Collaborate across teams to deliver intuitive, AI-powered solutions while ensuring performance and reliabi...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Media

$215K - $315K *

Lead the charge in building secure, compliant infrastructure for our DaaS platform. Drive engineering excellence while collaborating with cross-functional teams to meet the needs of regulated customer...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Innovate at the intersection of healthcare and technology. In this role, engineer ML pipelines, enhance data reliability, and ensure production stability for healthcare information systems, impacting...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$140K - $170K *

Lead the charge in integrating AI capabilities across enterprise platforms, enhancing digital services for Veterans. Collaborate with teams to implement innovative solutions while ensuring security an...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$70K - $118K *

Join a dynamic team to deliver impactful data analysis and reporting solutions, enhancing operational efficiency and decision-making through the Microsoft Power Platform and hands-on analytical suppor...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Business Services

$320K - $405K *

Design and oversee the electrical architecture for cutting-edge data centers, ensuring robust power distribution and integration of advanced technologies. Collaborate with partners to enhance prefabri...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Drive customer success by leading enterprise engagements and deploying AI solutions. Collaborate with cross-functional teams to ensure operational impact and long-term partnerships, enhancing efficien...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$175K - $210K *

Join us to lead the development of cutting-edge Operational AI solutions, collaborating with Global 2000 engineering teams. Drive technical integrity from architecture to production, ensuring impactfu...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$136K - $160K *

Elevate operations through AI-driven automation to enhance incident management, streamline ticket resolution, and optimize service health with self-healing observability, all while collaborating acros...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$180K - $230K *

Develop and evaluate advanced NLP models to transform unstructured data into actionable insights. Collaborate across teams, drive end-to-end solutions, and communicate effectively to bridge technical...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$139K - $151K *

Lead Finance analytics engineering and automation, transforming requirements into scalable data solutions. Collaborate with cross-functional teams to enhance data usability, reliability, and decision...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$180K - $240K *

The Technical Strategy & Execution Lead will oversee the execution of client, research, and product initiatives, transforming abstract ideas into actionable roadmaps. This role requires leading high-s...

RemoteRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Innovate cutting-edge AI financial solutions by architecting and deploying advanced chat interfaces and reporting systems. Collaborate with elite engineers to enhance investment workflows for global c...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$127K - $159K *

Lead a dynamic Data Engineering team to develop innovative data solutions, supporting essential healthcare operations. Drive operational effectiveness, compliance, and collaboration while enhancing da...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Drive impactful data strategies and analytics by leading a high-performing team, optimizing decision-making, and enhancing operational efficiency across the organization. Collaborate with stakeholders...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$160K - $200K *

Lead the technical direction for AI agent quality, defining metrics and evaluation systems. Collaborate with cross-functional teams to enhance agent performance and ensure quality in production enviro...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Empower decision-making by utilizing data-driven insights to enhance operations, supporting growth through statistical modeling and AI techniques while maintaining compliance in a complex regulatory e...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$147K - $275K *

Drive data-driven strategies by analyzing complex datasets and providing actionable insights. Collaborate with cross-functional teams to enhance decision-making processes and optimize business perform...

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $155K *

Lead and mentor a team of data engineers to design, develop, and maintain scalable data pipelines and warehouses, collaborating with stakeholders to deliver key metrics and establish data strategy acr...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Transportation

$150K - $180K *

Help us drive the future of automation by owning AI agents that onboard applications and ensure self-healing workflows. You'll enhance existing systems, prioritize security, and collaborate across tea...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $145K *

Join a team that's advancing data analytics for VA modernization initiatives. Utilize SQL and Python to drive AI-enabled insights, enhance operational workflows, and support decision-making through ri...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Business Services

$170K - $190K *

Transform data into actionable insights by leading a team of data scientists and analysts. Drive advanced analytics initiatives, foster collaboration with stakeholders, and ensure high-quality deliver...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$201K - $251K *

Transform workforce intelligence by leading People Analytics, establishing data governance, and driving strategic decision-making in a high-growth environment. Collaborate across functions to enhance...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Optimize your career by leading insights-driven strategies that shape brand decisions. Collaborate across functions to deliver actionable market research and analysis, driving impactful outcomes in a...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.