Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$87K - $253K *

Empower enterprise data initiatives by providing architectural leadership and governance. Guide teams in best practices for scalable data solutions, ensuring quality and compliance while fostering inn...

1 week ago

  •   8 - 10 years exp.  •   Business Services

$95K - $110K *

Drive impactful insights by analyzing real-world data in the life sciences sector. Collaborate with cross-functional teams to enhance patient care and support evidence-based decision-making through in...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$92K - $110K *

Unlock your potential by designing and optimizing scalable data solutions. Collaborate with cross-functional teams to enhance data reliability and efficiency while driving best practices in data manag...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Business Services

$128K - $165K *

Empower Fraud Operations by leading AI-driven automation initiatives, enhancing investigative workflows, and delivering actionable insights to optimize fraud detection and prevention efforts across th...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $100K *

Join a team that's driving financial insights and pricing strategies to enhance profitability. Collaborate with cross-functional teams to support client proposals and contract renewals while navigatin...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$198K - $233K *

Empower a team of engineers by architecting a robust AI-driven development pipeline, enhancing workflows across mobile and backend systems, and ensuring reliable, efficient software delivery for milli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$112K - $176K *

Unlock potential by leading the design and operation of cloud data platforms, ensuring reliability and governance while driving CI/CD practices. Collaborate with teams to enhance analytics capabilitie...

3 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$87K - $253K *

Innovate data solutions by building and optimizing scalable data pipelines, ensuring quality and governance while leveraging cloud technologies and best practices in data engineering and management...

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Unlock potential by driving research in prediction markets, developing alpha signals, and collaborating through the entire model implementation process. Guide projects from data analysis to live tradi...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$125K - $150K *

Join a dynamic team to design and build a robust data platform that enhances product performance and supports AI initiatives, ensuring data integrity and accessibility for internal and customer-facing...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$190K - $210K *

Champion data-driven strategies by leading GTM analytics and applied AI initiatives. Collaborate with Sales or Marketing leadership to optimize performance, drive impactful insights, and build innovat...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$155K - $320K *

Innovate robust frameworks and features as a senior engineer, collaborating with cross-functional teams to enhance user experiences and drive new initiatives from concept to release, impacting million...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$246K - $339K *

Champion the evolution of our Data Platform by architecting scalable solutions for large-scale data migrations, empowering teams with self-service storage capabilities, and ensuring reliability across...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$135K - $160K *

Lead the charge in solving critical engineering challenges, driving technical direction, and fostering team growth. Collaborate across departments to enhance systems, ensuring reliability and innovati...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Empower your career by bridging sales and engineering as a key technical resource. You'll scope, quote, and support customer needs for low and medium-voltage switchgear solutions, ensuring alignment w...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$109K - $173K *

Elevate your career by partnering with us to enhance financial forecasting and reporting processes. Leverage your analytical skills to improve business intelligence systems and drive key performance i...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Unlock potential by developing innovative deep learning models to enhance financial decision-making. Collaborate with a skilled team to translate complex data science concepts into impactful solutions...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$114K - $145K *

Shape your career as a Data Engineer, transforming raw data into impactful systems. Collaborate with stakeholders, optimize data architecture, and drive efficiency through automation while managing co...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Innovate solutions by bridging business challenges with AI-driven strategies. Lead stakeholder engagement, design value streams, and ensure technology investments yield measurable outcomes through eff...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Join a team that analyzes credit policies and develops strategies to enhance lending effectiveness, utilizes data analytics for risk management, and collaborates with stakeholders to drive impactful d...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$115K - $143K *

Unlock the potential of data by architecting scalable pipelines and driving analytics initiatives, mentoring engineers, and collaborating with cross-functional teams to enhance our data solutions in a...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $110K *

Discover a dynamic role where you'll enhance customer search experiences and backend systems. Collaborate across teams to deliver intuitive, AI-powered solutions while ensuring performance and reliabi...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Media

$215K - $315K *

Lead the charge in building secure, compliant infrastructure for our DaaS platform. Drive engineering excellence while collaborating with cross-functional teams to meet the needs of regulated customer...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Innovate at the intersection of healthcare and technology. In this role, engineer ML pipelines, enhance data reliability, and ensure production stability for healthcare information systems, impacting...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$140K - $170K *

Lead the charge in integrating AI capabilities across enterprise platforms, enhancing digital services for Veterans. Collaborate with teams to implement innovative solutions while ensuring security an...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.