Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Data Architect / Data Engineering Lead - Finance
$87K - $253K *
Empower enterprise data initiatives by providing architectural leadership and governance. Guide teams in best practices for scalable data solutions, ensuring quality and compliance while fostering inn...
1 week ago
$95K - $110K *
Drive impactful insights by analyzing real-world data in the life sciences sector. Collaborate with cross-functional teams to enhance patient care and support evidence-based decision-making through in...
1 week ago
$92K - $110K *
Unlock your potential by designing and optimizing scalable data solutions. Collaborate with cross-functional teams to enhance data reliability and efficiency while driving best practices in data manag...
Reposted 1 week ago
Manager of Business Analytics, Fraud Ops Automation
$128K - $165K *
Empower Fraud Operations by leading AI-driven automation initiatives, enhancing investigative workflows, and delivering actionable insights to optimize fraud detection and prevention efforts across th...
4 weeks ago
$80K - $100K *
Join a team that's driving financial insights and pricing strategies to enhance profitability. Collaborate with cross-functional teams to support client proposals and contract renewals while navigatin...
Reposted 2 days ago
$198K - $233K *
Empower a team of engineers by architecting a robust AI-driven development pipeline, enhancing workflows across mobile and backend systems, and ensuring reliable, efficient software delivery for milli...
1 week ago
Senior Data & AI Platform Engineer
$112K - $176K *
Unlock potential by leading the design and operation of cloud data platforms, ensuring reliability and governance while driving CI/CD practices. Collaborate with teams to enhance analytics capabilitie...
3 weeks ago
Data Engineering, Management, & Governance Manager - Finance
$87K - $253K *
Innovate data solutions by building and optimizing scalable data pipelines, ensuring quality and governance while leveraging cloud technologies and best practices in data engineering and management...
2 weeks ago
Quantitative Analyst - Prediction Markets
$110K - $130K *
Unlock potential by driving research in prediction markets, developing alpha signals, and collaborating through the entire model implementation process. Guide projects from data analysis to live tradi...
Reposted yesterday
Senior Data & AI Platform Engineer
$125K - $150K *
Join a dynamic team to design and build a robust data platform that enhances product performance and supports AI initiatives, ensuring data integrity and accessibility for internal and customer-facing...
4 weeks ago
Lead, GTM Analytics & Applied AI
$190K - $210K *
Champion data-driven strategies by leading GTM analytics and applied AI initiatives. Collaborate with Sales or Marketing leadership to optimize performance, drive impactful insights, and build innovat...
3 weeks ago
Sr Software Engineer, Monetization Engineering
$155K - $320K *
Innovate robust frameworks and features as a senior engineer, collaborating with cross-functional teams to enhance user experiences and drive new initiatives from concept to release, impacting million...
4 weeks ago
Principal Engineer, Data Platform
$246K - $339K *
Champion the evolution of our Data Platform by architecting scalable solutions for large-scale data migrations, empowering teams with self-service storage capabilities, and ensuring reliability across...
4 days ago
$135K - $160K *
Lead the charge in solving critical engineering challenges, driving technical direction, and fostering team growth. Collaborate across departments to enhance systems, ensuring reliability and innovati...
1 week ago
Application Engineer (Switchgear)
$95K - $115K *
Empower your career by bridging sales and engineering as a key technical resource. You'll scope, quote, and support customer needs for low and medium-voltage switchgear solutions, ensuring alignment w...
3 weeks ago
Senior Financial Analyst - Strategic Finance
$109K - $173K *
Elevate your career by partnering with us to enhance financial forecasting and reporting processes. Leverage your analytical skills to improve business intelligence systems and drive key performance i...
Reposted 1 week ago
Staff Data Scientist, Methodologies
$135K - $160K *
Unlock potential by developing innovative deep learning models to enhance financial decision-making. Collaborate with a skilled team to translate complex data science concepts into impactful solutions...
5 days ago
$114K - $145K *
Shape your career as a Data Engineer, transforming raw data into impactful systems. Collaborate with stakeholders, optimize data architecture, and drive efficiency through automation while managing co...
4 days ago
Sr. Business Analyst, AI & Data
$110K - $130K *
Innovate solutions by bridging business challenges with AI-driven strategies. Lead stakeholder engagement, design value streams, and ensure technology investments yield measurable outcomes through eff...
Today
$100K - $120K *
Join a team that analyzes credit policies and develops strategies to enhance lending effectiveness, utilizes data analytics for risk management, and collaborates with stakeholders to drive impactful d...
Reposted 2 weeks ago
$115K - $143K *
Unlock the potential of data by architecting scalable pipelines and driving analytics initiatives, mentoring engineers, and collaborating with cross-functional teams to enhance our data solutions in a...
Reposted 2 weeks ago
Senior Software Engineer, Search & AI
$95K - $110K *
Discover a dynamic role where you'll enhance customer search experiences and backend systems. Collaborate across teams to deliver intuitive, AI-powered solutions while ensuring performance and reliabi...
Today
Engineering Manager, Federal & Regulated Infrastructure
$215K - $315K *
Lead the charge in building secure, compliant infrastructure for our DaaS platform. Drive engineering excellence while collaborating with cross-functional teams to meet the needs of regulated customer...
2 weeks ago
$110K - $130K *
Innovate at the intersection of healthcare and technology. In this role, engineer ML pipelines, enhance data reliability, and ensure production stability for healthcare information systems, impacting...
Reposted 2 weeks ago
$140K - $170K *
Lead the charge in integrating AI capabilities across enterprise platforms, enhancing digital services for Veterans. Collaborate with teams to implement innovative solutions while ensuring security an...
6 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.