Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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$114K - $190K *

Build a resilient Site Reliability Engineering practice, leading a global team to enhance cloud platform reliability, scalability, and operational excellence while fostering collaboration and continuo...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$68K - $115K *

Unlock global payroll efficiency by managing accurate, timely payments across multiple countries. Leverage AI and automation to streamline processes, ensure compliance, and enhance employee experience...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $193K *

Drive innovation in data engineering by leading teams to design and deliver scalable data solutions. Collaborate with cross-functional partners to enhance analytics and decision-making, ensuring high...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Finance & Insurance

$199K - $235K *

Elevate your career as you design and maintain backend services that manage customer entitlements and usage workflows. Collaborate with cross-functional teams to ensure data integrity and deliver impa...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$128K - $191K *

Elevate your career by managing utility revenue requirements projects, preparing regulatory filings, and providing expert testimony. Collaborate with clients across North America while leading teams a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$100K - $152K *

Engineer innovative solutions in nuclear power plant systems design. Collaborate on modification packages, technical specifications, and vendor evaluations while leading project teams to enhance opera...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Technical Services

$78K - $126K *

Unlock potential by providing expert compliance advisory services to diverse organizations. Collaborate with clients to enhance grant management, internal controls, and operational effectiveness throu...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$72K - $116K *

Reimagine financial analysis by supporting Sales Incentive Plans, ensuring alignment with enrollment and financial goals. Collaborate with leaders and stakeholders to enhance accuracy, efficiency, and...

RemoteRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $158K *

Champion high-availability database platforms, driving automation and cloud modernization. Collaborate with engineering teams to enhance reliability and performance across hybrid environments, ensurin...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$158K - $197K *

Transform real-world health data into actionable insights by leveraging advanced bioinformatics and AI techniques. Lead innovative analyses in oncology and genomics, facilitating cross-functional coll...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Innovate with us to modernize a .NET insurance platform, leading a DevOps team to enhance CI/CD practices, automate infrastructure, and drive scalable architecture for improved stability and performan...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$145K - $225K *

Lead the charge in software development, driving innovation and collaboration across teams. Oversee strategic planning and team development to enhance product quality and efficiency, while fostering a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$175K - $215K *

Drive strategic growth and client satisfaction by managing senior-level relationships, leveraging cross-functional resources, and delivering measurable business value in a dynamic market environment...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$87K - $115K *

Optimize warehouse operations by implementing WMS solutions. Collaborate with teams to enhance workflows, lead testing, and ensure successful deployments, driving efficiency and scalability in logisti...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Transportation

$135K - $160K *

Unlock potential by leading transformative Salesforce solutions in financial services. As a trusted advisor, you'll architect scalable solutions, align technology with business goals, and drive best p...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $115K *

Join a team that's redefining healthcare project management. Lead integrated initiatives, mentor talent, and drive excellence across diverse campaigns while fostering collaboration and innovation in a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Innovate and shape the future of water resources and dam safety as a senior engineer. Lead impactful projects, enhance client relations, and mentor emerging talent while collaborating with experts acr...

Reposted 5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Accelerate progress at our growing company by driving sales for enterprise software, nurturing channel partnerships, and exceeding targets in a fast-paced environment that values commitment and innova...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Transform your career by leading lean initiatives to enhance productivity and streamline processes. Drive continuous improvement across manufacturing and office functions while fostering a culture of...

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$200K - $350K *

Transform complex AI research into scalable, reliable systems. Collaborate across teams to architect and enhance backend services, ensuring robust infrastructure for model training and data collection...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$130K - $170K *

Lead the development of innovative data solutions, integrating AI/ML capabilities and optimizing data pipelines within Palantir Foundry and Databricks. Collaborate with cross-functional teams to enhan...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Business Services

$80K - $95K *

Engineer innovative solutions as a Project Engineer, overseeing diverse projects from design to execution. Collaborate with teams to ensure quality standards and effective communication, driving conti...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Technical Services

$121K - $161K *

Transform your career by leading the design and implementation of Veeva Vault RIM, ensuring optimal performance and compliance while collaborating with cross-functional teams to enhance user experienc...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$115K - $151K *

Transform technology operations by leading financial management, procurement, vendor oversight, and asset management. Drive strategic decision-making and operational excellence to enhance service deli...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$195K - $235K *

Drive innovation in autonomous systems by building robust platforms for AI agents, ensuring seamless execution and user-friendly interfaces while tackling complex distributed systems challenges across...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.