Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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$80K - $133K *

Innovate with us to deliver AI and machine learning solutions that transform data into actionable insights. Collaborate across teams to enhance fraud detection and anomaly analysis, leveraging advance...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$160K - $190K *

Lead and develop a team of Product Managers to drive AI-powered product strategy, governance, and investment decisions. Shape the organization's AI capabilities while ensuring responsible AI practices...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$103K - $192K *

Shape the future of healthcare reimbursement by leading analytics for payor contracting and out-of-network strategies. Collaborate with cross-functional teams to optimize financial outcomes and drive...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$86K - $119K *

Lead the charge in building and supporting enterprise data solutions that transform business requirements into scalable models, enhancing analytics and reporting capabilities across the organization...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Drive the delivery and maintenance of Interactive Response Technology (IRT) systems, ensuring successful client interactions and project outcomes through effective oversight, training, and support man...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Join a team that's dedicated to transforming data into actionable insights. As a Senior Analyst, you'll tackle complex challenges, support strategic initiatives, and collaborate with experts to enhanc...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$210K - $256K *

Accelerate progress at a leading consulting firm by managing a large-scale data transformation program. Oversee governance, stakeholder alignment, and change management across multiple workstreams to...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $140K *

Lead the charge in implementing and maintaining ISO 27001:2022 compliance, driving cross-functional initiatives, and enhancing the Information Security Management System while collaborating with diver...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$108K - $156K *

Empower your career by leading revenue analytics, overseeing financial analysis, and enhancing payer contract strategies. Collaborate with cross-functional teams to optimize reimbursement and drive or...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$243K - $251K *

Join a team that's dedicated to enhancing internal audit processes through innovative risk management strategies, leveraging data analytics and technology to drive efficiency and compliance across the...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$78K - $100K *

Lead the end-to-end program management for enterprise clients in financial services, driving alignment and execution across cross-functional teams to achieve measurable business outcomes and ensure se...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Media

$150K - $175K *

Shape the cloud infrastructure landscape by ensuring security, scalability, and efficiency. Collaborate with engineers to build resilient systems and drive best practices, enabling smooth deployment a...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Join a team that's driving enterprise growth by managing key accounts, expanding relationships, and executing strategic plans. Leverage your expertise to enhance customer value and influence major org...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$105K - $129K *

Drive impactful market analysis and reporting as a Senior Analyst, leveraging data to guide strategic investments and growth opportunities. Collaborate with teams to enhance decision-making and optimi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$90K - $120K *

Unlock quality assurance excellence by leading automation efforts and mentoring teams. Drive the development of robust testing frameworks and enhance product reliability across multiple platforms in a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$152K - $259K *

Transform security analysis by leading the development of a static analysis engine. Shape technical direction, mentor engineers, and drive initiatives that enhance code security and performance across...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$140K - $175K *

Join a team that's shaping security and compliance across the company. You'll lead HITRUST and SOC 2 programs, ensuring data protection while collaborating with engineering and legal teams in a hands...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Drive innovative strategies in generative engine optimization, leading client accounts and teams to enhance visibility and authority in AI-driven search landscapes while ensuring measurable outcomes a...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$165K - $220K *

Pioneer innovative solutions by collaborating with defense clients to operationalize real-time intelligence. Design and deploy data pipelines and applications on Palantir Foundry, ensuring mission-cri...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$195K - $312K *

Zillow is seeking a Principal Applied Scientist to join the Agentic AI team, focusing on developing advanced multimodal technologies for understanding homes. The role involves designing and prototypin...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$200K - $235K *

Take ownership of impactful software projects, driving end-to-end development across backend and frontend technologies. Collaborate with cross-functional teams to enhance customer experiences and ensu...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$180K - $190K *

Unlock potential by managing and automating cloud infrastructure, ensuring system security, and optimizing CI/CD pipelines. Collaborate with teams to enhance reliability and performance in a dynamic...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$200K - $220K *

Manage and elevate a team of engineers to deliver AI-powered healthcare solutions. Oversee project planning, architecture, and team development while ensuring high-quality outcomes in a fast-paced, re...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$133K - $197K *

Drive impactful research by leading technical evaluations and benchmarks in AI. Collaborate with diverse stakeholders to ensure principled guidance that integrates social and technical considerations...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$156K - $262K *

Join a dynamic team to design and optimize scalable data pipelines and infrastructure, enabling analytics and AI-driven capabilities. Collaborate across functions to deliver high-quality data solution...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.