Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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$150K - $180K *

Lead the charge in enhancing engineering security for our SaaS platform. Collaborate with teams to identify risks, improve practices, and implement automation, ensuring secure development and robust v...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$202K - $253K *

Drive the development of AI-driven coaching solutions, overseeing multiple squads from prototype to production. Ensure quality delivery, manage resources effectively, and foster team growth while main...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Join a team that's shaping the future of AI by designing and implementing enterprise-grade solutions on Google Cloud and Azure, focusing on data migration, pipeline development, and robust cloud infra...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$94K - $110K *

Shape financial strategies by providing expert analysis and insights into capital generation. Collaborate with cross-functional teams to enhance reporting and drive process improvements while mentorin...

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $125K *

Optimize security operations by triaging and investigating alerts, mitigating cyber threats effectively. Join a dedicated team to enhance your analyst skills while actively protecting organizations fr...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Lead feasibility strategy and execution for clinical studies, driving operational excellence and data-driven insights to optimize trial planning and enrollment across rare disease programs. Collaborat...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $250K *

Shape the cloud infrastructure for AI agents, ensuring secure, scalable solutions that enhance customer workflows. Lead architectural decisions, establish standards, and drive innovation in a dynamic...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$95K - $115K *

Elevate your career by contributing to critical security initiatives, leveraging your expertise in incident response, cryptographic modernization, and technical policy formulation to enhance enterpris...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$89K - $156K *

Transform enterprise budgeting solutions by analyzing processes, defining requirements, and configuring applications. Collaborate with stakeholders to enhance financial planning and ensure successful...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$90K - $100K *

Join a team that's dedicated to optimizing payroll operations and compliance. This role supports payroll processing, reporting, and employee services, ensuring accuracy and scalability as the organiza...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Optimize internal tooling ecosystems to enhance operational efficiency. Collaborate with engineering to develop AI-driven solutions and automate workflows that streamline team processes and enable sca...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$162K - $203K *

Drive impactful market research initiatives by collaborating with cross-functional teams to translate business needs into actionable insights, ensuring high-quality execution and strategic decision-ma...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$104K - $130K *

Empower your career by designing, deploying, and optimizing cutting-edge AI & ML infrastructures in dynamic client environments. Collaborate with cross-functional teams to drive innovation and excelle...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Unlock potential by leading analytics initiatives, transforming data into actionable insights, and mentoring junior analysts. Collaborate with stakeholders to enhance reporting solutions and drive ope...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$75K - $105K *

Collaborate with clients to enhance their social media strategies using healthcare insights, data-driven execution, and creative content development for multi-channel success. This role demands a proa...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$128K - $214K *

Help us shape the future of data science by developing advanced analytics and machine learning solutions for federal clients. Collaborate with a dynamic team to drive impactful data-driven decisions a...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Accelerate sales growth by leading strategies and initiatives across the ANZ market. Collaborate with a multidisciplinary team to drive customer engagement, develop market strategies, and achieve reve...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join a dynamic team to bridge product strategy and engineering delivery, transforming data into actionable insights for innovative financial solutions. Collaborate with cross-functional teams to drive...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$138K - $201K *

Transform provider analytics by leading data-driven insights for contracting, performance, and network strategy. Collaborate with cross-functional teams to enhance network adequacy and drive strategic...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$116K - $148K *

Transform enterprise operations by guiding customers in AI adoption and maximizing Asana's capabilities. Own post-sales relationships, ensuring measurable outcomes and strategic success across a portf...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$131K - $209K *

Engage with teams to deliver comprehensive AI enablement programs, designing tailored learning paths and fostering a culture of proficiency across all departments. Collaborate closely with HR to integ...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Information Technology

$59K - $164K *

Join a team that's transforming application security through modernization and DevSecOps. Leverage your expertise to enhance cloud resilience, implement advanced security practices, and guide clients...

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$120K - $150K *

Champion continuous improvement initiatives by optimizing processes and products across the organization. Lead cross-functional teams to enhance operational efficiency, quality, and customer experienc...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$230K - $275K *

Lead the charge in vulnerability research and exploitation techniques, transforming real-world threats into automated solutions. Collaborate with teams to enhance security measures and validate defens...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$98K - $163K *

Shape the future of enterprise software by building secure, scalable applications. Collaborate with cross-functional teams to integrate AI capabilities and deliver innovative solutions that meet busin...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.