Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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$84K - $105K *

Drive project success by managing client relationships and leading implementation strategies. Collaborate with teams to assess needs, develop plans, and ensure timely delivery while navigating challen...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$84K - $105K *

Deliver exceptional client engagement by managing project success, assessing needs, and developing strategic plans. Lead cross-functional teams to ensure timely and budget-compliant implementations wh...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$255K - $295K *

Lead the technical direction for foundational services, guiding architecture and execution across teams to enhance platform capabilities for customer and partner experiences. Mentor engineers and infl...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$128K - $188K *

Drive your career with impactful technical sales in the medical device sector. Lead customer engagements, identify new business opportunities, and collaborate with cross-functional teams to enhance pr...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$124K - $210K *

Drive customer success by leading a team of engineers to enhance GitLab adoption, develop scalable enablement programs, and collaborate with cross-functional teams to achieve measurable business outco...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$132K - $338K *

Lead the charge in embedding Responsible AI across the lifecycle, managing global teams, and architecting production-grade AI solutions while ensuring ethical standards and governance are met througho...

3 weeks ago

  •   8 - 10 years exp.  •   Business Services

$110K - $130K *

Oversee the design and development of clinical databases while ensuring project timelines and quality standards are met. Collaborate across teams to provide technical support and mentor team members...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $150K *

Innovate as you guide Fortune 500 clients in leveraging AI solutions. Collaborate with sales teams, deliver dynamic presentations, and serve as trusted technical advisor to modernize legacy systems an...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$88K - $115K *

Empower organizational change by analyzing stakeholder needs and implementing effective strategies. Collaborate with leadership and teams to enhance processes, ensuring smooth transitions and measurab...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Business Services

$180K - $230K *

Join a dynamic team as you lead engineering efforts to develop an AI Patient Engagement Agent, transforming clinical trials by automating patient interactions and enhancing operational efficiency for...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$181K - $214K *

Lead the charge in defining and executing on-platform measurement strategies, ensuring effective ad performance tracking and reporting across diverse ad formats while collaborating with engineering an...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Technical Services

$110K - $130K *

Elevate your career by leading SCADA design and engineering for high-voltage electrical power systems. Collaborate with a multi-disciplinary team to optimize substation projects, ensuring efficient ex...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$115K - $140K *

Join us to drive revenue growth by engaging senior finance leaders, executing full-cycle sales, and delivering tailored software solutions that address financial challenges and enhance operational eff...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $128K *

Analyze and monitor security alerts, investigate threats, and enhance SOC processes. Collaborate with teams to ensure cybersecurity measures are effective, while documenting incidents and providing te...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$80K - $128K *

Elevate cybersecurity operations by monitoring threats, analyzing network traffic, and coordinating incident responses. Collaborate with teams to enhance security measures and mentor junior analysts w...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$103K - $154K *

Unlock advanced data solutions by leveraging Microsoft Azure and Power BI. Collaborate with teams to deliver high-quality analytics and reporting, while enhancing business intelligence capabilities th...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$100K - $120K *

Engage clients by driving the full sales cycle of AI solutions, converting leads and exploring growth opportunities while collaborating across teams to enhance client outcomes and product evolution...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$175K - $218K *

Join a team that's redefining revenue growth through innovative ML solutions. As a Lead Data Scientist, you'll drive impactful monetization strategies for millions of users, collaborating across teams...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$229K - $330K *

Transform financial strategy for GTM operations, driving growth through data-driven insights and modernized processes. Collaborate with cross-functional teams to enhance performance, optimize investme...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$110K - $165K *

Unlock potential by designing and maintaining robust data pipelines and Power BI models to transform operational data into actionable insights for stakeholders, ensuring data integrity and performance...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Business Services

$123K - $154K *

Lead the execution of strategic data and analytics initiatives, driving modernization and governance across enterprise platforms. Collaborate with cross-functional teams to ensure alignment and accoun...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Join us in designing and deploying scalable automation solutions that enhance operational efficiency and streamline business processes. Collaborate with cross-functional teams to transform requirement...

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$150K - $281K *

Champion digital transformation in manufacturing by leading regional initiatives, enhancing operational technologies, and fostering self-sustaining capabilities across sites to drive data-driven solut...

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $140K *

Lead the charge in architecting and building intelligent systems for autonomous GRC workflows, leveraging C#/.NET and Blazor to create scalable, high-performance solutions that drive innovation and ef...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$130K - $155K *

Collaborate to design and develop scalable solutions for modern data platforms, utilizing Python and cloud technology. Drive innovation through AI-assisted tools, while building robust data pipelines...

RemoteRemote

Reposted 1 month ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.