Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$188K - $235K *

Grow your career with a hands-on leadership role in GTM analytics, driving data-driven decisions across Sales, Marketing, and Customer Success. Shape analytics products and insights to enhance pipelin...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$69K - $107K *

Champion client success by leveraging technical expertise to enhance platform value, optimize workflows, and drive measurable outcomes. Collaborate with cross-functional teams to deliver innovative so...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$166K - $279K *

Collaborate with cross-functional teams to drive technical success in prioritized opportunities, leveraging deep expertise in a specific product group to influence customer decisions and enhance Solut...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Lead the charge in transforming data accessibility for product teams and AI agents. Oversee a team of data engineers to build a robust platform that ensures secure, reliable data usage across the orga...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$110K - $130K *

Innovate in cancer research by designing and deploying advanced AI and machine learning solutions. Collaborate with cross-functional teams to develop multimodal models integrating diverse clinical dat...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $115K *

Champion integrated media strategies for pharmaceutical clients, driving engagement and measurable outcomes. Lead cross-functional teams to develop innovative solutions that address complex healthcare...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$238K - $280K *

Shape the future of AI/LLM security by leading innovative offensive strategies, defining technical vision, and driving cross-company initiatives to enhance NodeZero's capabilities in identifying and e...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $120K *

Accelerate progress at the intersection of media and healthcare by leading integrated planning and strategy for pharmaceutical clients. Drive impactful engagement initiatives while mentoring a talente...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$211K - $248K *

Lead the charge in managing the complete ML model lifecycle, ensuring robust deployment, monitoring, and continuous improvement. Collaborate with data scientists to enhance model performance and opera...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$75K - $90K *

Transform financial insights into strategic initiatives, supporting planning and analysis as the organization scales. Collaborate across teams to enhance budget management, reporting, and performance...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$115K - $145K *

Elevate your career by designing and optimizing data pipelines that empower analytics and AI solutions. Collaborate with cross-functional teams to ensure data integrity and governance while mentoring...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Transform complex customer implementations into seamless successes by owning the delivery lifecycle, driving technical discussions, and ensuring stakeholder satisfaction from kickoff to go-live. Your...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$177K - $364K *

Empower a team of engineers to enhance Kubernetes platform infrastructure, driving reliability, security, and efficiency while collaborating across departments to achieve strategic goals and operation...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$110K - $130K *

Champion data-driven insights by transforming complex analytics into clear narratives for senior leadership, enhancing risk oversight and strategic decision-making across the organization...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$145K - $185K *

Join a dynamic team as a Senior Marketing Analytics Manager, driving marketing performance measurement and insights. Collaborate cross-functionally to build impactful reporting and attribution models...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $130K *

Drive commercial activation and revenue growth for a multi-million-dollar portfolio, leveraging strategic insights and AI to enhance client engagement and decision-making. Lead cross-functional teams...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$195K - $270K *

Lead a dynamic team of analysts and data scientists to optimize marketing strategies, driving impactful insights and experimentation across channels to enhance growth and performance metrics for the o...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$95K - $115K *

Shape the future of electrical engineering by collaborating with design teams, ensuring technical compliance, and enhancing performance across diverse projects. Join us to tackle innovative challenges...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Shape the future of healthcare by owning and optimizing AI systems. Design and deliver scalable ML solutions that transform operations, enhance decision-making, and create real-world impact across cri...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$75K - $90K *

Elevate financial insights as a Senior Financial Analyst, partnering with leaders to drive strategic planning, budgeting, and reporting. Leverage your analytical skills to enhance operational performa...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$466K - $500K+*

Unlock potential by developing scalable AI/ML model serving infrastructure. Collaborate cross-functionally to enhance performance and availability of high-traffic systems, driving innovation in a dyna...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$133K - $173K *

Shape the future of AI governance by designing frameworks and policies that ensure responsible innovation and effective risk management across the enterprise. Collaborate with cross-functional teams t...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$180K - $300K *

Partner with us to tackle complex data challenges and enhance frontier AI model performance. In this critical role, engage with leading AI labs to design innovative datasets and environments while tra...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$93K - $154K *

Transform claims analysis by leveraging deep operational insights to identify patterns and anomalies. Collaborate with cross-functional teams to develop advanced data mining capabilities that enhance...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Business Services

$120K - $150K *

Innovate within a cutting-edge DataOps environment, ensuring the reliability and scalability of a Databricks-native data platform on Azure. Leverage AI for observability and pipeline management while...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.