Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$180K - $225K *

Transform the future of auto claims by designing AI agents that enhance decision-making and streamline processes. Join a dynamic team to build innovative solutions that improve efficiency and accuracy...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$105K - $124K *

Lead and optimize research intern activities, ensuring alignment with project goals and technical standards. Manage workflows, provide coaching, and conduct hands-on research while supporting the Dire...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Explore advanced revenue analysis and month-end controls to ensure accurate invoicing and financial reporting. Collaborate across functions to resolve discrepancies, mentor junior analysts, and drive...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Empower your career by ensuring quality assurance and training for DRG Reviewers. Contribute to improving clinical documentation and auditing processes while fostering an environment of continuous lea...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Information Technology

$124K - $280K *

Transform healthcare through AI and ML solutions, leading teams to develop impactful data-driven strategies. Drive innovation in clinical decision support and operational efficiency while engaging wit...

3 weeks ago

  •   11 - 15 years exp.  •   Legal & Accounting

$100K - $167K *

Drive efficiency at the intersection of product development and customer engagement by building integrations and automations that empower teams with timely, relevant product knowledge and streamline w...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$124K - $171K *

Champion advanced machine learning techniques to develop multimodal AI systems in biomedical applications, collaborating with cross-functional teams to enhance personalized oncology diagnostics and im...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$112K - $132K *

Join a team that's shaping the future of autism care by building robust statistical methodologies. You'll analyze real-world clinical data, ensuring rigorous evaluation of outcomes and social validity...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$183K - $216K *

Innovate the analytical roadmap for ranking and relevance, collaborating with cross-functional teams to enhance user engagement and advertiser outcomes while driving long-term platform economics and s...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$140K - $160K *

Drive sales growth by engaging with decision-makers in government agencies. Build relationships, identify opportunities, and collaborate with teams to deliver Investigative Intelligence solutions acro...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$163K - $204K *

Unlock potential by leading innovative machine learning methods for cancer detection, collaborating with experts, and mentoring junior scientists to advance research in multi-cancer early detection us...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $180K *

Empower your career by delivering AI observability solutions end-to-end. Collaborate with a cross-functional team to enhance user experiences and drive insights into AI systems, shaping the future of...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$109K - $125K *

Optimize enterprise strategy and analytics by transforming complex data into actionable insights. Collaborate across functions to enhance decision-making and support strategic initiatives through effe...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $200K *

Innovate robust ML infrastructure to enhance AI capabilities, ensuring seamless model deployment and performance. Collaborate with teams to streamline processes and drive impactful ML systems from res...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$82K - $137K *

Transform business insights into actionable data solutions by collaborating with stakeholders, analyzing data quality, and ensuring effective integration of analytical products to drive operational ef...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$145K - $185K *

Lead and inspire engineering teams to deliver high-quality digital products, ensuring alignment with business priorities while fostering a culture of collaboration and continuous improvement in a dyna...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$149K - $224K *

Drive analytics excellence by leading a team to deliver impactful insights, enhance reporting capabilities, and support strategic decision-making across diverse business functions. Foster collaboratio...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$140K - $160K *

Architect the future of intelligent K-12 assessment systems by designing a robust knowledge architecture that integrates AI, learning science, and psychometrics. Innovate and build foundational struct...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$90K - $100K *

Join a team that's dedicated to managing regulatory and audit processes, ensuring compliance and operational readiness. As a Senior Analyst, you'll coordinate responses, conduct analysis, and enhance...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Elevate data-driven decision-making by analyzing clinician networks to optimize patient care. Collaborate with cross-functional teams to enhance operational efficiency and improve healthcare outcomes...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$105K - $202K *

Create innovative AI-powered healthcare products by transforming complex workflows into intuitive applications. Collaborate with cross-functional teams to deliver impactful user experiences and own fe...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$170K - $200K *

Join a dynamic team to design and implement scalable data pipelines, transforming diverse data sources into actionable insights. Collaborate with cross-functional experts to drive innovation and maint...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$149K - $198K *

Elevate your career by leading data-driven evaluation methodologies for autonomous systems. Collaborate with cross-functional teams to ensure performance metrics align with safety standards, driving i...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Transportation

$100K - $130K *

Unlock your potential as a Senior Financial Analyst, driving financial insights and models to support growth. Collaborate across teams to enhance forecasting accuracy and optimize performance, playing...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Finance & Insurance

$130K - $155K *

Elevate your career by designing and developing high-scale Identity Resolution systems. Collaborate with cross-functional teams to create reliable, secure, and high-performance solutions that link and...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.