Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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$150K - $180K *

Empower engineering teams to innovate advertiser tools, driving technical strategy and delivery while enhancing user experience across self-service and managed workflows in a dynamic ad tech environme...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Technical Services

$115K - $151K *

Advance your career by leading financial reporting and forecasting efforts. Collaborate across departments to analyze data, streamline processes, and support strategic planning in a dynamic, high-grow...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Transform your career by leading full-cycle recruiting for GTM roles. Collaborate with executives to define hiring standards, build strong talent pipelines, and drive strategic hiring initiatives in a...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$184K - $356K *

Develop metrics and evaluation methodologies to enhance Autonomous Vehicle software. Collaborate across teams to innovate testing strategies and deliver data-driven insights, driving forward cutting-e...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Innovate your career with a key role supporting the global launch and technical operations of radiopharmaceuticals, driving compliance, quality initiatives, and collaboration with CDMOs while leading...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$163K - $369K *

Lead enterprise software sales initiatives, driving revenue growth and managing client relationships. Oversee a small sales team and collaborate with partners to enhance pipeline origination and achie...

2 days ago

  •   11 - 15 years exp.  •   Business Services

$225K - $418K *

Champion advanced analytics to enhance patient outcomes through data-driven insights. Lead a team in analyzing healthcare data, fostering strategic partnerships, and communicating complex findings to...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $207K *

Innovate AI and ML systems as a Principal Architect, collaborating with teams to design agentic architectures and scalable solutions. Drive production delivery while shaping standards and best practic...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Finance & Insurance

$130K - $140K *

Contribute to the development of a modern platform by building features, connecting systems, and improving data usability. Engage with stakeholders and troubleshoot to deliver reliable software as par...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Staffing

$95K - $115K *

Engage as a Data Visualization Engineer to design and develop advanced Power BI solutions, leveraging AI for enhanced analytics and user experiences. Collaborate with stakeholders to transform complex...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$115K - $130K *

Join a dynamic team as you provide essential IT support to a distributed workforce. Leverage your troubleshooting skills to resolve technical issues, enhance user experience, and contribute to a colla...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$255K - $290K *

Drive the technical vision for a complex database platform, ensuring scalability and performance. Lead architecture decisions, mentor engineers, and collaborate across teams to enhance data infrastruc...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$138K - $165K *

Champion the development of LLM-powered applications and agentic systems. Drive complex use cases from ambiguous problems to production, ensuring high-quality and scalable AI solutions that address us...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $185K *

Unlock potential by designing and deploying AI systems that enhance translational science, enabling evidence-based recommendations for drug discovery and target validation through innovative technolog...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$122K - $171K *

Unlock potential by driving data-driven insights for Customer Success. Collaborate across teams to enhance customer journeys, optimize growth strategies, and shape analytics foundations that support A...

RemoteRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Information Technology

$170K - $190K *

Shape the future of data engineering by leading architectural improvements, enhancing data quality, and driving technical initiatives across diverse business domains. Collaborate with stakeholders to...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$155K - $258K *

Shape the future of AI in healthcare by leading architectural design and technical strategy for LLM-powered systems. Mentor engineers, ensure compliance, and drive innovation in a highly regulated env...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $105K *

Unlock potential by conducting advanced quantitative analyses in behavioral health research. Collaborate with senior investigators on diverse projects, manage data, and produce insightful reports to d...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$118K - $147K *

Drive successful project delivery by implementing cutting-edge AI/ML solutions on Google Cloud. Collaborate with cross-functional teams to develop strategies, conduct client discovery, and provide tec...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$100K - $187K *

Engage clients as a trusted advisor, develop and execute strategic account plans, and drive business growth through effective relationship management in data and analytics services...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$153K - $210K *

Strategize and enhance data integrity across extensive systems, ensuring all operational data is accurate and reliable for key clinical and financial workflows while enabling self-serve analytics for...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$320K - $405K *

Innovate the future of data center power generation and microgrids. Own the architecture for on-site generation and storage systems, ensuring reliable energy solutions that meet demanding load profile...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$173K - $245K *

Unlock insights through data analytics and experimentation to enhance credit risk management. Collaborate with cross-functional teams to optimize policies, monitor performance, and drive strategic gro...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $145K *

Analyze and uncover fraud patterns using large-scale data to enhance protection strategies. Collaborate with cross-functional teams to develop insights and solutions that directly impact fraud prevent...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$81K *

Manage and enhance public health technology platforms, ensuring secure, reliable operations for local, state, and federal agencies. Collaborate with cross-functional teams to optimize system performan...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.