Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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$85K - $161K *

Unlock potential by deploying and supporting enterprise AI solutions, enhancing client readiness, and driving adoption through hands-on development and consulting. Collaborate with cross-functional te...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $145K *

Lead the charge in advancing AI applications in healthcare by developing intelligent agents that uncover financial opportunities within complex datasets, transforming manual analyses into scalable wor...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$129K - $177K *

Lead the charge in designing and delivering AI capabilities for a platform, integrating advanced workflows and intelligent analysis while actively contributing to production code and managing a small...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $185K *

Optimize product performance through data-driven insights, collaborating with cross-functional teams to define metrics, analyze customer behavior, and support strategic planning for impactful product...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Join a team that's redefining data solutions by leading the Data Products & Engineering department, shaping cutting-edge data architectures and innovative client-facing analytics solutions that drive...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$178K - $294K *

Join a team that's redefining data engineering and analytics. Lead strategy, architecture, and execution of scalable data solutions while mentoring professionals and driving business outcomes through...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$192K - $202K *

Lead the technical roadmap and modernize data solutions infrastructure, enhancing off-platform integrations and measurement capabilities while driving AI-first engineering initiatives and cross-team c...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$111K - $167K *

Join a dynamic team as a strategic analytics partner, driving insights and performance improvements across revenue cycle operations. Collaborate with leaders to define KPIs, analyze data, and create i...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$313K - $365K *

Unlock potential by shaping the future of consumer insights through advanced data science. Lead measurement and modeling strategies to enhance user engagement and community dynamics, driving impactful...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Media

$180K - $200K *

Deliver innovative backend solutions that enhance integrations and streamline security workflows. Collaborate with experts to build reliable services, ensuring seamless connectivity and improved inves...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $165K *

Analyze complex data from multiple sources to derive actionable insights that drive client success. Collaborate closely with cross-functional teams to create reports and recommendations tailored to cl...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$160K - $170K *

Elevate data engineering excellence by designing and implementing complex data solutions, mentoring engineers, and collaborating across teams to drive impactful data initiatives and architectural inno...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$91K - $118K *

Accelerate your career by driving technical solutions and proposals for engineered equipment. Collaborate with sales and engineering teams to ensure customer satisfaction and secure new business oppor...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$240K - $270K *

Champion advanced analytics to drive strategic insights and business growth. Lead a hands-on team, collaborating with cross-functional partners to enhance product performance, retention, and decision...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Food & Beverages

$173K - $290K *

Lead the measurement strategy for platform impact, defining metrics and evaluations that drive actionable insights. Collaborate with engineering to operationalize data infrastructure, ensuring quality...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Real Estate & Construction

$190K - $267K *

Transform safety enforcement through data science by developing models and systems that detect and mitigate abuse. Collaborate across teams to translate policies into actionable insights, ensuring eff...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Media

$200K - $270K *

Join a team pioneering AI/ML platform engineering, enhancing scalable infrastructure to empower scientific innovation. Shape the future of distributed systems and MLOps, collaborating across teams to...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$170K - $272K *

Advance your career by leading the development of scalable ML systems that drive impactful business outcomes through data science innovation and collaboration with cross-functional teams...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$130K - $242K *

Lead advanced analytics initiatives to enhance MAU insights, driving growth through experimentation and causal inference. Collaborate across teams to establish standards and leverage AI for scalable s...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$90K - $110K *

Join a team that's dedicated to enhancing HR data integration. Leverage your Workday expertise to design, implement, and maintain seamless connections between systems, ensuring data integrity and perf...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Develop and implement MLOps strategy for enterprise-grade ML systems, driving model lifecycle management. Collaborate with teams to design scalable pipelines and ensure high reliability across ML solu...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Innovate and drive AI agent development for clinical trial platforms, integrating LLMs through the .NET stack. Engage in hands-on engineering to deliver end-to-end AI features, enhancing patient-centr...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Transform the future of marketing by designing and deploying AI-driven growth systems. This hands-on role merges engineering and marketing to enhance customer engagement and streamline operations thro...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$150K - $180K *

Architect scalable Generative AI solutions using AWS tools, focusing on LLMs, RAG, and agent-based workflows. Collaborate with teams to ensure performance and cost efficiency while guiding implementat...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Drive the transformation of AI solutions by developing, deploying, and optimizing machine learning models. Collaborate with stakeholders to create innovative applications that enhance patient care whi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.