Job Description

Vertex is seeking an exceptional scientific leader to drive the development and incorporation of human disease models and assays into drug discovery programs. The Sr. Director, Pharmacology will lead a department responsible for the design, development, and execution of in vitro and in vivo assays that support the progression and optimization of human therapeutics, including assays used todeterminedrug potency, efficacy, and mechanism of action. This leader will also serve as a member of the San Diegobiologyleadership team and help shape siteresearchdirectionand cross-departmental projects.

KeyDuties &Responsibilities

• Direct pharmacology strategy, including assays that assess potency, efficacy, and mechanism of action andprovidescientific, operational, andpeopleleadership across multiple programs and teams.
• Lead the Pharmacology function and manage a team responsible for in vitro and in vivo assays that support drug discovery and therapeutic optimization.
• Set team priorities,allocateresources, manage budgets andhiring, and ensure progress against company goals.Mentor and develop staff, promote ethical scientific practices, and support a high-performingteamculture.
• Drive study planning, data quality, reporting, publications, patents, and compliance withregulatorydocumentation standards.
• Partner across functions and sites to influence research direction, reduce project risk, and advance innovative solutions.
• Communicate priorities, capabilities, progress, and recommendations clearly to project teams, collaborators, senior management, and across a matrixed organization.

Knowledge and Skills:

• Strong leadership and strategic thinking, with the ability to lead scientists and coordinate cross-functional drug discovery efforts.
• Provenpeoplemanagement skills, including mentoring, recruiting, and developing scientific teamsincluding Ph.D. scientists and Research Associates.
• Deepexpertisein pharmacology,including invitro/in vivo assay design, execution, analysis, and interpretation.Strong knowledge of pharmacological principles and the drug discovery process.
• Extensive experience with ion channel pharmacology/electrophysiology and mechanism-of-action studies.
• Evidence of developing innovative translational in vitro and/or in vivo models that predict human efficacy.
• Ability to analyze complex data, communicate findings clearly, and recommendnextsteps to varied audiences.
• Proven ability to work effectively in a fast-paced, matrixed research environment.
• Excellent written and verbal communication skills, with credibility across senior leadership and scientific stakeholders.

Education and Experience:

• Ph.D. in Pharmacology, or a related field, with relevant post-doctoralindustryemployment experience.
• 12+ years of drug discovery experience withdemonstratedexcellence in early-stage drug discovery and development.
• Successfultrack recordmanaging functional or cross-functional research groups, including Ph.D. Scientists and Research Associates.

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Pay Range:

Disclosure Statement:

Flex Designation:

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertexs Policy on Flex @ Vertex Program and may be changed at any time.

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