Personalis

Software Engineer Lead

Personalis$190K — $220K *
Healthcare
5 - 7 years of experience
Job Overview by Ladders

Qualifications

  • Bachelor's degree in Computer Science, IT, Engineering, or related field.
  • 6+ years of software development experience.
  • 2+ years in a technical lead or senior engineer role.
  • Expertise in Python, Java, JavaScript, and modern software engineering principles.
  • Experience in regulated healthcare or laboratory environments.
  • Strong Agile methodology knowledge, including Scrum and Kanban.

Responsibilities

  • Lead design, development, testing, and maintenance of software applications.
  • Act as a hands-on implementation lead for software projects with a small team.
  • Participate in software design, code reviews, and troubleshooting activities.
  • Champion software best practices and collaborate with QA on risk analysis.
  • Support Agile development processes including sprint planning and backlog refinement.
  • Ensure software compliance with regulatory standards.
  • Assist with validation, documentation, audit readiness, and compliance activities.

Benefits

  • Medical, dental, and vision insurance.
  • 401(k) matching contributions.
  • Employee Stock Purchase Plan (ESPP).
  • Tuition reimbursement.
  • Sick/vacation time and commuter benefits.
  • Onsite gym access and wellness benefits.
Full Job Description
Summary:

We are seeking an experienced Software Engineer Lead to provide technical leadership for the development, enhancement, and support of software applications in a regulated clinical laboratory environment. This role will lead the design and delivery of software solutions, guide engineering best practices, mentor team members, and collaborate closely with business and technical stakeholders to deliver secure, reliable, and compliant applications.

The ideal candidate combines strong software engineering expertise, hands-on development experience, operational awareness, and experience working in regulated healthcare environments. This individual will serve as a technical leader for the team, driving software quality, architectural consistency, and successful project execution while supporting critical laboratory and business operations.

Onsite: Monday, Tuesday, and Thursday

Responsibilities:
  • Lead the design, development, testing, deployment, and maintenance of software applications supporting laboratory and business operations.
  • Be a hands-on implementation lead for software projects using the latest technologies for software development and integrations, and also manage a small team of engineers for this.
  • Participate actively in software design, code reviews, troubleshooting, and implementation activities.
  • Be a champion of software best practices in partnership with QA by conducting risk analysis, identifying test data, and improving CI/CD within Informatics and stakeholder teams aimed at high quality deliverables.
  • Promote engineering best practices for software quality, security, performance, maintainability, and reliability.
  • Support Agile development processes including sprint planning, backlog refinement, estimation, and release planning.
  • Ensure software solutions comply with applicable regulatory requirements including HIPAA, CLIA, CAP, FDA (as applicable), and internal quality standards.
  • Support validation, documentation, audit readiness, and compliance activities.

Requirements:
  • Bachelor's degree in Computer Science, Information Technology, Engineering, or related field.
  • 6+ years of software development experience.
  • 2+ years serving as a technical lead, senior engineer, or equivalent leadership role.
  • Demonstrated expertise across the full software development stack, including Python, Java, JavaScript, database design and management, DevOps practices, CI/CD automation, and modern software engineering principles.
  • Experience working in a regulated healthcare, diagnostics, laboratory, or life sciences environment.
  • Experience supporting production applications and resolving complex technical issues.
  • Experience working with distributed or offshore development teams.
  • Experience with enterprise application and automation system integrations.
  • Strong understanding of Agile methodologies including Scrum and Kanban.
  • Experience with cloud platforms such as AWS, Azure, or GCP.
  • Strong experience with APIs, microservices, and modern application architectures.
  • Excellent problem-solving, analytical, and communication skills.

The hiring range for this position is $190,000 to $220,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.)

#LI-KK1 #LI-Hybrid

About Personalis

Personalis is a biotechnology company that specializes in genomic sequencing and analysis. The company provides services to pharmaceutical and biotech companies, as well as research institutions. Personalis was founded in 2011 and is headquartered in Menlo Park, California.
Learn more about Personalis
Size
325 employees
Market Cap
$80.6 million
Industry
Net Income
-$41.2 million
Founded
2011
Revenue
$78.6 million
NASDAQ

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