Software Engineer - AI Accelerated Development

Signant Health

$90K — $130K *
US-Anywhere
+ 2 other locationsRemote
Information Technology
Less than 5 years of experience
Job Overview by Ladders

Qualifications

  • 5-7 years in full-stack .NET development with C#/ASP.NET Core
  • Hands-on experience building AI agents and agentic workflows, beyond simple LLM prompting
  • Integration experience with LLM APIs such as OpenAI or Azure OpenAI
  • Demonstrated success in delivering AI features from backend to user-ready front-end
  • Proficiency in using Claude Code (or similar) as a primary development tool
  • Solid skills in prompt engineering for production-scale applications
  • Python experience preferred, familiarity with async patterns a plus

Responsibilities

  • Design and create AI agents and workflows to enhance clinical trial platforms
  • Integrate LLM APIs into .NET applications, managing all aspects from authentication to latency
  • Deliver AI capabilities from backend systems to production-ready front-ends
  • Build custom agents and manage their operational loops using the Claude Agent SDK
  • Develop specialized skills and commands for Claude Code to fit team workflows
  • Implement RAG pipelines and connect vector stores for reliable data management
  • Ensure agents are evaluable and transparent to meet regulatory standards

Benefits

  • Collaboration with cutting-edge AI technologies
  • Opportunity to work in a highly regulated, high-impact environment
  • Focus on rapid development and production shipping of AI features
  • Engagement in innovative projects with substantial real-world applications
  • Supportive work culture that values hands-on experience and continuous learning
Full Job Description
About the Role

Signant Health is looking for a Software Engineer - AI Accelerated Development to build AI-powered, agentic features into our clinical trial platforms. Working across the .NET stack, you will take AI capabilities from backend LLM integration through to a usable front-end - designing agents and agentic workflows, not just prompting a model. This is a hands-on engineering role for someone who works with agentic tooling every day and wants to ship production AI in a regulated, high-impact environment. We weigh the depth of your AI and agentic build experience more heavily than years of general experience: a developer with one to three years of substantive, hands-on agentic work is exactly the profile we are targeting.

KEY ACCOUNTABILITIES - Function

  • Design and build AI agents and agentic workflows - tool-use/function calling, multi-step task orchestration, and agent loops - that power Signant Health's clinical trial platforms.
  • Integrate LLM APIs (Anthropic, OpenAI, Bedrock, or Azure OpenAI) into .NET application code, handling authentication, streaming, error handling, and cost/latency tradeoffs.
  • Deliver AI features end-to-end, taking them from backend integration through to a usable, production-ready front-end.
  • Build custom agents and tools with the Claude Agent SDK, wiring and steering agent loops.
  • Author custom skills and slash commands for Claude Code to codify team-specific workflows.
  • Implement RAG pipelines and integrate vector stores (e.g. Qdrant, pgvector, Pinecone) to ground agent outputs in trusted data.
  • Instrument agents for evaluation and observability so their outputs can be verified, measured, and audited.
  • Apply AI-specific risk controls appropriate to a regulated clinical environment, addressing hallucination, determinism, and auditability of agent decisions.
  • Use Claude Code (or an equivalent agentic CLI) daily as a primary development tool, reviewing and steering AI-generated diffs.


KNOWLEDGE, SKILLS & ATTRIBUTES

Essential:
  • Full-stack .NET development - C#/ASP.NET Core on the backend paired with a modern front-end framework.
  • Hands-on agentic development experience - building AI agents or agentic workflows (tool-use/function calling, multi-step task orchestration, agent loops); not just prompting an LLM, but building systems around one.
  • Practical LLM API integration (Anthropic, OpenAI, Bedrock, or Azure OpenAI), including authentication, streaming, error handling, and cost/latency tradeoffs.
  • Proven full-stack delivery of AI features - able to take an agentic/AI feature from backend integration through to a usable front-end, not just a notebook prototype.
  • Daily, hands-on use of Claude Code (or an equivalent agentic CLI) as a primary development tool - comfortable working through multi-step agentic sessions and reviewing and steering AI-generated diffs, rather than occasional autocomplete-style use.
  • Prompt engineering - designing and iterating on system prompts as production software contracts, not one-off experiments.
  • Python proficiency as the preferred language for AI/agent tooling; comfort with async patterns a plus.
  • Evaluation and observability literacy - able to reason about whether an agent's output is correct and instrument it to prove so.


Desirable:
  • Claude Agent SDK experience - building custom agents, defining tools, and wiring agent loops.
  • Working knowledge of agent primitives: hooks (deterministic pre/post-tool-call controls), skills (progressive-disclosure, load-on-demand instructions), subagents/multi-agent delegation, and session/state management.
  • Experience authoring custom skills or slash commands for Claude Code to codify team-specific workflows.
  • Exposure to MCP (Model Context Protocol) for connecting agents to internal tools and data sources.
  • Working knowledge of RAG patterns and vector store integration (e.g. Qdrant, pgvector, Pinecone).
  • Awareness of AI-specific risk areas relevant to a regulated environment (OWASP LLM Top 10, hallucination/determinism concerns, and auditability of agent decisions).

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