10X Genomics

Senior Technical Program Manager, Productivity Engineering (Data Platform · AI Transformation)

10X Genomics$164K — $222K *
Information Technology
5 - 7 years of experience
Job Overview by Ladders

Qualifications

  • 5+ years of TPM experience managing complex, multi-stakeholder programs.
  • Experience in mid-stage startups (Series A-D) or as a founder, understanding the dynamics of building from the ground up.
  • Hands-on experience with data infrastructure or data platform projects including pipelines and real-time flows.
  • Proficient in modern integration patterns including event-driven architecture and API design.
  • Proven track record of creating and owning project roadmaps.
  • Strong written and verbal communication skills.

Responsibilities

  • Own and drive the roadmap for AI/Data Platform and Finance integration programs.
  • Take programs from zero to shipped through effective scoping and risk management.
  • Translate ambiguous business problems into structured programs with clear milestones.
  • Drive delivery independently, creating your own playbook as needed.
  • Hold teams accountable to commitments without relying on hierarchy.
  • Design programs with a focus on enabling AI and ML capabilities.
  • Ensure integration reliability across applications and modern tech stacks.

Benefits

  • Equity grants as part of the total compensation package.
  • Comprehensive health and retirement benefits program.
  • Annual bonus or sales incentive program.
Full Job Description
About the Role

We are looking for a Senior TPM who thrives in ambiguity, builds the plan rather than inherits one, and understands that data programs are not just delivery work - they are the foundation that makes AI possible. You will own the roadmap across our AI / Data Platform and integration programs, and you will expand your scope as the org scales.

You have operated in environments where the process did not exist yet - and you built it. You do not wait for a fully-defined charter. You are energized by a flat org, a direct reporting line to leadership, and the expectation that you own outcomes end-to-end.
What You Will Own
Program Ownership & Delivery
  • Own and drive the roadmap across AI / Data Platform and Finance integration programs; expand scope as the business grows.
  • Take programs from zero to shipped - scoping, sequencing, dependency management, risk visibility, and retrospective.
  • Translate ambiguous business problems into structured, time-bound programs with clear milestones and decision points.
  • Run delivery end-to-end without needing a playbook handed to you. You write the playbook.
  • Hold engineering, product, and business teams accountable to commitments - without relying on hierarchy to do it.
AI-First Thinking
  • Understand how Data Platform programs create upstream capability for AI and ML - design with that lens from day one.
  • Own AI-specific program tracks: NLQ rollout, Bedrock integrations, model deployment pipelines, and data readiness for AI.
  • Partner with Data Engineering, Product, and Science teams to ensure programs are not just delivered but compound into AI readiness.
  • Push teams to think end-to-end: what does this program unlock downstream, and are we building toward that?
  • Represent the AI program portfolio to senior leadership with clarity on status, risks, and strategic trajectory.
Finance & Application Integrations
  • Own delivery of modernized integration programs - ensuring cross-application flows (ERP, CRM, supply chain) work reliably on a modern tech stack.
  • Drive the retirement of fragile legacy middleware and the adoption of event-driven, scalable integration patterns.
  • Partner with Finance, Operations, and Engineering to translate business process requirements into well-architected integration programs.
  • Ensure tax, order management, procurement, and revenue-impacting workflows have zero-tolerance reliability standards.
  • Define the integration roadmap in partnership with architects and engineering leads - own it, defend it, and ship it.
Leadership & Communication
  • Operate effectively in a flat org: influence without hierarchy, build alignment without bureaucracy.
  • Be the connective tissue across Engineering, Product, Finance, and Operations - translate technical complexity into business impact.
  • Identify cross-program risks before they become incidents. Escalate with a proposed solution, not just a flag.
Minimum Requirements
  • 5+ years of TPM experience with demonstrated ownership of complex, multi-stakeholder programs.
  • Meaningful time at a mid-stage startup (Series A-D), or equivalent experience as a founder or early employee - you know what it means to build without a safety net.
  • Hands-on delivery across data infrastructure or data platform programs: pipelines, warehousing, ELT, real-time data flows.
  • Fluency in modern integration patterns - you can hold a substantive conversation with engineers about event-driven architecture, API design, and middleware retirement without needing a glossary.
  • Proven ability to build the roadmap, not inherit one. You have done this before and have the scars to show it.
  • Strong written and verbal communication - you can write a crisp exec update and a detailed program brief and know when each is appropriate.
Preferred Skills and Experience
  • Experience driving AI or ML programs: NLQ, model deployment pipelines, feature stores, or GenAI product integrations.
  • Familiarity with the 10x stack or equivalent: Snowflake, Airflow, Kafka, dbt, AWS, Oracle Fusion.
  • Background in life sciences, genomics, or regulated data environments.
  • Worked cross-functionally across Engineering, Product, Finance, and Operations simultaneously - not sequentially.


Below is the base pay range for this full-time position. The actual base pay will depend on several factors unique to each candidate, including one's skills, qualifications, and experience. At 10x, base pay is also just one component of the Company's total compensation package. This role is also eligible for 10x's equity grants, its comprehensive health and retirement benefit programs, and its annual bonus program or sales incentive program. During the hiring process, your 10x recruiter can share more about the Company's total compensation package.

Pay Range

$164,100-$222,100 USD

About 10X Genomics

10x Genomics is a biotechnology company that develops and manufactures gene sequencing technology. The company's products enable researchers to study biological systems at a previously unattainable resolution, allowing them to gain a deeper understanding of the underlying mechanisms of disease. 10x Genomics' technology is used in a wide range of applications, including cancer research, immunology, and neuroscience. The company was founded in 2012 and is headquartered in Pleasanton, California.
Learn more about 10X Genomics
Size
1,239 employees
Market Cap
$3.8 billion
Industry
Net Income
-$542.7 million
Founded
2012
Revenue
$298.8 million
NASDAQ

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