THE ROLEExpedition is seeking a motivated and innovative
SeniorScientist, Proteomics to join our team. In this role, you will play a critical role in the development and application of cutting-edge chemoproteomics workflows to support drug discovery programs and platform innovation. The successful candidate will combine strong experimental expertise in mass spectrometry-based proteomics with quantitative data analysis skills to enable biological insight and drive decision-making across multidisciplinary discovery teams.
This individual will contribute to the advancement of a state-of-the-art chemical proteomics platform supporting targeted chemoproteomics, lead compound characterization, and biomarker discovery efforts. The ideal candidate is highly collaborative, scientifically rigorous, and capable of independently driving projects in a fast-paced research environment.
KEY RESPONSIBILITIES- Operate, maintain, and troubleshoot state-of-the-art LC-MS instrumentation, including Orbitrap Tribrid platforms with FAIMS
- Develop, optimize, and execute targeted chemoproteomics workflows to support discovery programs
- Design and improve scalable sample preparation and experimental workflows for high-throughput proteomics applications
- Analyze and interpret large-scale proteomics datasets using quantitative and statistical approaches
- Collaborate closely with proteomics, biology, chemistry, and computational teams to design experiments, interpret results, and guide project strategy
- Develop and implement innovative chemical proteomics technologies and methodologies to enhance platform capabilities
- Communicate findings and technical advances clearly across cross-functional teams
PROFESSIONAL EXPERIENCE & QUALIFICATIONS - Ph.D. in analytical chemistry, chemical biology, biochemistry, or a related discipline with 4+ years of industry experience, or M.S. degree with 6+ years of industry experience
- Extensive hands-on experience with mass spectrometry-based proteomics workflows and instrumentation
- Experience with quantitative proteomics methods including TMT, DIA, PRM, or related approaches
- Experience with targeted chemoproteomics workflows and applications
- Experience with peptide mapping and/or intact mass spectrometry is preferred
- Proficiency in analyzing complex, large-scale proteomics datasets using computational methods and programming languages such as Python or R
- Expert level understanding of proteomics data analysis software (e.g. MSFragger, ProteomeDiscoverer, Spectronaut, MaxQuant)
- Strong understanding of experimental design, assay optimization, reproducibility, and quantitative data interpretation
- Experience with laboratory automation platforms (e.g., Hamilton, Agilent Bravo) is a plus
- Excellent communication and cross-functional collaboration skills
- Demonstrated ability to work independently and manage multiple priorities in a fast-paced environment
LOCATION: Cambridge, MA
The salary range for this role is $126,000 - $159,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Expedition Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Expedition Medicines's good faith estimate as of the date of publication and may be modified in the future.
