Job Title: Senior Scientist - Process Modelling

• Location: Framingham, MA

Main responsibilities:

• Develop, calibrate, and validate bioreactor dynamic models to simulate, optimize, and control recombinant protein production and product quality attributes

• Transfer and deploy bioreactor models in a commercial manufacturing environment to support process monitoring and forecasting (digital shadows) and/or real-time bioreactor optimization and control (digital twins)

• Work as part of matrix project teams with cell-culture development, process development, analytical, automation, and data science teams across R&D and Manufacturing.

• Communicate model assumptions, uncertainty, limitations, and process interpretation to technical and non-technical stakeholders

• Maintain reproducible computational workflows using appropriate coding, documentation, version control, and data-management practices

• Act as a change agent to support the implementation of process modeling in established cell culture process development workflows

• Document progress against deliverables with rigorous scientific communication via technical presentations, reports and, when appropriate, scientific publications

About You

Basic Qualifications

Education

• PhD in Chemical Engineering, Biochemical Engineering, Process Systems Engineering, Bioengineering, Biomedical Engineering, or related engineering or scientific discipline

• OR Master's degree in any of the above fields

Experience

• PhD holders: Minimum1 yearof relevant experience

• Master's holders: Minimum4 yearsof relevant industry or research experience

• Academic, research assistantship, or industry experience will be considered

• Demonstrated experience developingdynamic models of bioreactor or cell culture processes

• Proficiency in at least one scientific computing language:Python, MATLAB, Julia, or R

Preferred Qualifications

• Experience developing dynamicmechanistic modelsusing ordinary differential equations (ODEs), kinetic rate laws, mass balances, parameter estimation, and model validation

• Strong understanding ofmammalian cell culture process development, including fed-batch and/or perfusion bioreactor operation

• Proven track record of developing and deployingbioreactor digital twins, process models, or advanced monitoring tools in an industrial biopharmaceutical environment

• Understanding ofbioreactor engineering principles: oxygen transfer, mixing, mass transfer, CO3 stripping, kLa, shear, scale-up and scale-down models

• Experience withperfusion bioreactor modeling: cell retention, bleed strategies, media exchange, residence time, productivity, and steady-state operation

• Experience withmultivariate statistical process monitoringtechniques such as PCA or PLS for early fault detection

• Familiarity withsoft sensors, state estimation, Kalman filtering, moving-horizon estimation, or real-time process monitoring and model predictive control

• Track record ofpeer-reviewed publicationsin process modeling/simulation for upstream biopharmaceutical processes

• Prior experience working withinternational/global teamsacross multiple time zones and locations

The position will be based in Framingham on the Sanofi campus. A free Shuttle service is available from downtown Boston.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law

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Better is out there. Better medications, better outcomes, better science. But progress doesn 27t happen without people 6 people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let 27s be those people.

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US and Puerto Rico Residents Only

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally inclusive and diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; natural or protective hairstyles; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

North America Applicants Only

The salary range for this position is:

All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs. Additional benefits information can be found through the .