Flagship Pioneering

(Senior) Scientist, Optical Technologies

Flagship Pioneering$100K — $180K *
Pharmaceuticals & Biotech
Less than 5 years of experience
Job Overview by Ladders

Qualifications

  • PhD or equivalent experience in relevant scientific disciplines (physics, biophysics, chemistry, engineering).
  • Extensive hands-on experience with optical microscopy and vibrational spectroscopy (e.g., Raman microscopy, IR spectroscopy).
  • Strong background in executing and troubleshooting complex experiments independently.
  • Solid understanding of optics and engineering principles of optical instrumentation.
  • Ability to distinguish meaningful biological signals from experimental noise.

Responsibilities

  • Design and conduct experiments utilizing advanced optical and vibrational spectroscopy techniques.
  • Manage a portfolio of experiments, collaborating with universities, CROs, and internal teams.
  • Create and document experimental workflows and standard operating procedures for improved measurement processes.
  • Identify and resolve instrumentation issues to enhance experimental data quality.
  • Research emerging methodologies to inform new experimental opportunities.
  • Contribute to the scientific vision and technical direction of a new venture.

Benefits

  • Opportunity to join a founding scientific team working on cutting-edge technology.
  • Engage in a multidisciplinary environment fostering creativity and curiosity.
  • Contribute to the establishment of new experimental capabilities in a startup setting.
  • Potential for professional growth as the company evolves and scales.
Full Job Description
Help Expand What We Can See in Biology

At Flagship Labs 120, we're assembling a multidisciplinary team to invent, build, and rapidly test innovative technologies for observing biological systems. We are looking for a scientist with deep hands-on experience in optics and vibrational spectroscopy to join the team and help turn promising experimental opportunities into practical capabilities for the platform.

This is a zero-to-one role for an engineering-minded scientist who enjoys turning new ideas into practical experiments. We are looking for someone who favors fast, practical, hands-on solutions and will help shape the scientific direction and experimental foundation of a new venture through work across instrumentation, biology, and external collaborations.

Responsibilities
  • Design and execute experiments using advanced optical and vibrational spectroscopy measurement techniques to characterize biological systems.
  • Own a portfolio of internal and external experiments, coordinating work across CROs, university core facilities, academic collaborators, and internal teams.
  • Develop, refine, and document experimental workflows, protocols, and SOPs to improve measurement quality, reproducibility, and operational efficiency.
  • Troubleshoot instrumentation, identify sources of experimental variability, and improve data quality and reproducibility.
  • Stay current across relevant fields to identify promising new experiments and applications.
  • Contribute to the scientific strategy and technical roadmap of a founding-stage venture.

Qualifications

Required
  • PhD (or equivalent experience) in physics, biophysics, chemistry, engineering, bioengineering, or a related discipline.
  • Deep hands-on experience developing and applying optical microscopy and vibrational spectroscopy techniques such as Raman microscopy, IR spectroscopy, or related methods.
  • Strong experimental background and demonstrated ability to independently execute and troubleshoot complex experiments.
  • Solid understanding of the physics and engineering of optical instrumentation.
  • Strong scientific judgment and the ability to distinguish meaningful biological signals from technical artifacts.

Preferred
  • Experience developing or optimizing advanced Raman spectroscopy (e.g. CARS, SRS) or IR spectroscopy (e.g. photothermal IR), or related techniques.
  • Experience working with biological samples such as cells or tissue. Familiarity with cell culture or live cell assays is a plus.
  • Familiarity with molecular or cell biology sufficient to understand literature and adopt new experimental protocols.
  • Programming or scripting experience (Python, MATLAB, or similar) for instrument automation and experimental data analysis.
  • Experience working with external collaborators, university core facilities, or CROs.
  • Previous experience in startup, translational, or highly interdisciplinary research environments.

Why Join FL120?

This is an opportunity to join a founding scientific team exploring an entirely new experimental platform. Success will require curiosity, creativity, and a willingness to cross traditional disciplinary boundaries. You'll play an important role in exploring new ideas, establishing new experimental capabilities, and helping shape the scientific direction of a company from its earliest days.

As the company grows, this role will help shape the evolution of our platform and broader technical strategy.

We welcome applications from experienced scientists as well as exceptional postdoctoral researchers or advanced graduate students interested in either full-time or part-time opportunities.

About Flagship Pioneering

Flagship Pioneering is a life sciences innovation enterprise that conceives, creates, resources, and develops first-in-category life sciences companies. The firm operates through its Flagship Labs unit, which is a dedicated innovation foundry that invents and launches transformative companies. Flagship Pioneering has created over 100 scientific ventures, resulting in over $34 billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents. The firm's portfolio includes companies in the fields of therapeutics, health technologies, and sustainability. Flagship Pioneering was founded in 2000 and is headquartered in Cambridge, Massachusetts.
Learn more about Flagship Pioneering
Size
500 employees
Industry

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