Career CategoryScientific
Job Description Senior Scientist - LCMS What you will doLet's do this. Let's change the world. In this vital role, you will join the Pharmacokinetics & Drug Metabolism - Bioanalytical Sciences (PKDM-BA) group to advance Amgen's growing research portfolio. The successful candidate will develop and apply innovative LC-MS-based bioanalytical assays to quantify therapeutic candidates, assess target engagement and modulation, characterize target dynamics, and measure biomarkers across discovery and development programs.
The PKDM-BA team works in close partnership with cross-functional teams to support candidate selection, preclinical development, clinical evaluation, and regulatory submissions, including IND and NDA filings.
Key Responsibilities- Develop, optimize, and perform quantitative LC-MS assays to measure therapeutics of all modalities (including exposure and biotransformation), biomarkers and target dynamics (including target abundance, target engagement/ occupancy, target turnover kinetics, and cellular trafficking of target).
- Design and implement bioanalytical strategies that support mechanistic understanding of drug-target interactions, pathway modulation, pharmacodynamic responses, and biomarker kinetics.
- Apply quantitative mass spectrometry-based workflows to support studies in complex biological matrices, including plasma, tissue, and in vitro systems.
- Explore, evaluate, and implement emerging analytical technologies to support novel therapeutic modalities, including complex biologics, multispecific molecules, targeted protein degradation platforms, oligonucleotide-based modalities, and other emerging therapeutic approaches.
- Independently troubleshoot assay development, sample preparation, data quality, and LC-MS instrument performance issues.
- Collaborate with cross-functional project teams to interpret bioanalytical data in the context of PK/PD, translational biomarkers, target biology, and mechanisms of action.
- Maintain accurate electronic laboratory notebook records, prepare technical reports, and communicate scientific results clearly to project teams and stakeholders.
What we expect of youWe are all different, yet we all use our unique contributions to serve patients. The scientific professional we seek will bring strong quantitative bioanalytical expertise, hands-on LC-MS experience, scientific curiosity, and a commitment to advancing development of innovative therapeutics through rigorous measurement of drug, target, and biomarker biology.
Basic Qualifications:Doctorate degree in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, Chemical Biology, Proteomics, or a related discipline with strong LC-MS training
ORMaster's degree and 3 years of relevant experience
ORBachelor's degree and 5 years of relevant experience
Preferred Qualifications:- Proven expertise in LC-MS method development and quantitative bioanalysis in complex biological matrices.
- Experience developing and applying quantitative assays for therapeutics, target engagement, target modulation, target dynamics, and biomarker biology.
- Hands-on experience with targeted or untargeted proteomics workflows, including peptide mapping, enzymatic digestion, protein-drug adduct identification, intact or subunit analysis, and quantitative protein or peptide assays.
- Experience with sample preparation techniques such as biological matrix processing, tissue homogenization, immunoaffinity capture, and other fit-for-purpose bioanalytical approaches.
- Experience with automated sample preparation platforms such as AssayMAP Bravo, Tecan, KingFisher, or related systems.
- Hands-on experience with LC-MS platforms, including high-flow, micro-flow, or nano-flow LC systems, triple quadrupole, Q-TOF, and Orbitrap systems.
- Ability to independently troubleshoot analytical methods, sample preparation workflows, data quality issues, and instrument performance.
- Strong communication, collaboration, and data interpretation skills, with the ability to present complex analytical results to multidisciplinary project teams.
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.
Apply now and make a lasting impact with the Amgen team.careers.amgen.comIn any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
Application deadlineExternal/Internal postings: Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
Internal only posting (or Pre-ID candidate): Amgen anticipates accepting applications however, we may continue accepting applications beyond this date if we do not receive a sufficient number of candidates.
SponsorshipSponsorship for this role is not guaranteed.
Salary Range143,820.85USD -194,581.15 USD
