General Description: Candidates must be able to work onsite in San Carlos, California.As a Senior Scientist at BeOne Institute, you will independently design and execute high-quality research studies supporting discovery and translational programs in immunology, inflammation, and immuno-oncology. You will contribute to target evaluation, mechanistic understanding, and therapeutic development through generation of rigorous, decision-enabling data.
Essential Functions of the Job: - Identify and advance high-value therapeutic targets across immunology, inflammation and immuno-oncology therapeutic areas, aligned with organizational strategy, portfolio priorities and emerging scientific opportunities.
- Independently design, execute, analyze and interpret in vitro, ex vivo, and in vivo studies to validate target biology, establish disease rationale, evaluate therapeutic modalities, develop mechanistic insight, and generate decision-enabling data packages.
- Communicate progress through regular updates while proactively identifying challenges and proposing solutions.
- Collaborate with cross-disciplinary or cross-functional teams and drive innovation within and beyond the Institute.
- Contribute to management and operational activities to support strategic objectives of the BeOne Institute at the San Carlos site.
Supervisory Responsibilities: - May mentor junior scientists, research associates, interns
Requirements: - Requirements:
Travel: No - Ph.D., M.D., or equivalent advanced degree in one or more of the following areas : cancer biology, immuno-oncology, immunology, epithelial and stromal biology, stem cell biology or a related life sciences discipline. 2+ years of related experience.
- Demonstrated track record of scientific achievements, as evidenced by publications in high-impact journals.
- Demonstrated ability to design experiments, generate high-quality data, analyze complex datasets, and communicate scientific findings effectively.
- Hands-on experience with relevant laboratory techniques such as primary human/mouse epithelial and stromal cell culture, air-lift culture, epithelial organoid culture, cell line engineering, histology, IHC, IF, flow cytometry, ELISA, MSD, molecular biology methods, protein characterization, microscopy/high-content imaging, or related experimental platforms.
- Experience with one or more of the following is preferred: in vitro and in vivo disease models, AI-driven protein design, protein engineering, induced proximity technologies, synthetic biology approaches, or other innovative therapeutic platforms.
- Knowledge of biologics, small molecules and other complex modalities, experience with omics data analysis, and/or preclinical immunology and oncology mouse models is a plus.
- Ability to operate effectively in a highly collaborative, fast-paced, and interdisciplinary research environment, and to integrate multi-disciplinary approaches to solve complex biological problems.
- Strong collaboration skills across functional and disciplinary boundaries.
- Excellent communication and presentation skills, with the ability to clearly articulate complex scientific concepts to both technical and non-technical audiences.
Education Required: Ph.D., M.D., or equivalent advanced degree
Travel: No
Salary Range: $150,200.00 - $187,800.00 annually
BeOne is committed to fair and equitable compensation practices. Actual compensation packages are determined by several factors that are unique to each candidate, including but not limited to job-related skills, depth of experience, certifications, relevant education or training, and specific work location. Packages may vary by location due to differences in the cost of labor. The recruiter can share more about the specific salary range for a preferred location during the hiring process. Please note that the listed range reflects the base salary or hourly range only. Non-Commercial roles are eligible to participate in the annual bonus plan, and Commercial roles are eligible to participate in an incentive compensation plan. All Company employees have the opportunity to own shares of BeOne Medicines Ltd. stock because all employees are eligible for discretionary equity awards and to voluntarily participate in the Employee Stock Purchase Plan. The Company has a comprehensive benefits package that includes Medical, Dental, Vision, 401(k), FSA/HSA, Life Insurance, Paid Time Off, and Wellness.
