Merck & Co, Inc

Senior Scientist, Cytometric Profiling

Merck & Co, Inc • $131K — $206K *
South San Francisco, CA 94080In-Person
Pharmaceuticals & Biotech
Less than 5 years of experience
Today
Be an Early Applicant
Job Overview by Ladders

Qualifications

  • Bachelor's degree with 7+ years or Master's with 4+ years or Ph.D. in Biology, Immunology, or related discipline
  • Experience with traditional Flow Cytometry, preferably BD Biosciences or Beckman Coulter
  • Knowledge of Spectral Cytometry, preferably Cytek Biosciences
  • Proficient with FlowJo data analysis software
  • Strong background in immunologic assays including T cell and myeloid stimulation techniques
  • Excellent communication and team collaboration skills
  • Ability to interface with cross-functional colleagues effectively.

Responsibilities

  • Design and execute controlled flow cytometry experiments in a BSL-2 lab
  • Develop preclinical biomarker assays using flow cytometry methods
  • Represent the Cytometric Profiling group in team meetings
  • Present findings at lab and department gatherings
  • Maintain complete and compliant laboratory documentation
  • Support daily operations of the FACS core lab

Benefits

  • Relocation assistance available
  • Visa sponsorship provided
  • Flexible work arrangements not applicable
  • Employee status: Regular
  • No travel required for the position
Full Job Description
Job Description

The successful candidate will focus on the Immunology therapy area by profiling therapeutic targets of interest in primary human healthy and disease tissue using high-dimensional flow cytometry. Indications relevant to this work include autoimmune, inflammatory, atopic, and fibrotic diseases. Profiling data will support preclinical and early clinical program development as well as translational efforts in Immunology or other therapy areas as needed. This position requires a proactive, innovative, organized, and detail-oriented scientist who can work collaboratively across multiple functional areas to support the development of our company's pipeline.

Job responsibilities include the following:
  • Independently designing and executing properly controlled experiments for deep profiling of primary human tissue using flow cytometry in a BSL-2 laboratory environment
  • Developing flow cytometry-based preclinical biomarker assays
  • Representing the Cytometric Profiling group in team meetings while actively engaging with stakeholders across the Research and Development Division's network
  • Presenting results at lab, team, or department meetings
  • Maintaining a detailed, complete, and compliant laboratory notebook
  • Help supporting daily operations of FACS core lab


QUALIFICATIONS:

Education:
  • Bachelor's (with 7+ years), Master's (with 4+ years) or Ph.D. in Biology, Immunology, or related discipline and relevant industry or postdoctoral experience


Required Experience and Skills:
  • Experience with traditional Flow Cytometry, preferably with BD Biosciences or Beckman Coulter flow cytometers
  • Knowledge of Spectral Cytometry, preferably with Cytek Biosciences spectral cytometers
  • Proficiency with FlowJo data analysis software
  • Knowledge of immunologic assays: T cell and myeloid cell stimulation, phospho-STAT or NFkB intracellular staining, ELISA
  • Cell culture and tissue dissociation techniques
  • Excellent communication and interpersonal skills, as well as the ability to function in a team environment
  • Ability to interface with translational, discovery, and clinical cross-functional colleagues to drive assay development and implementation into discovery and/or clinical programs as needed
  • Proficiency with MS Office applications on the Windows operating system


Preferred Experience and Skills:
  • Immunology and/or Immuno-Oncology background
  • Experience with cell sorting (FACS), preferably with Cytek spectral cell sorters
  • Cell preparation for single cell RNA-sequencing as well as Total-seq staining
  • Single cell RNA-sequencing using the 10X Genomics platform
  • Proficiency with high-dimensional data clustering and analytical methods
  • Proficiency with TIBCO Spotfire, GraphPad Prism, OMIQ
  • With management guidance, ability to incorporate cutting edge scientific and technical advances to support Profiling & Expression priorities


#EligibleforERP

Required Skills:
Cell Culture Techniques, Cytometry, Flow Cytometry, Immunoassays, Immunology, Immunology Research, T Cell Immunology, Tissue Cultures

Preferred Skills:

Current Employees apply HERE

Current Contingent Workers apply HERE

Employee Status:
Regular

Relocation:
Domestic/International

VISA Sponsorship:
Yes

Travel Requirements:
No Travel Required

Flexible Work Arrangements:
Not Applicable

Shift:
1st - Day

Valid Driving License:
No

Hazardous Material(s):
N/A

Job Posting End Date:
09/24/2026
*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

About Merck & Co, Inc

Schering-Plough Corporation is a major U.S.-based manufacturer of pharmaceuticals. It operates in three segments: Prescription Pharmaceuticals, Animal Health, and Consumer Health Care. Schering-Plough develops products targeting on allergy, cancer, hepatitis, cardiovascular, central nervous system, respiratory system, and more.  It was founded in 1851 by Ernst Christian Friedrich Schering as Schering AG in Germany. Schering-Plough manufactured several pharmaceutical drugs, the most well-known of which were the allergy drugs Claritin and Clarinex, an anti-cholesterol drug Vytorin, and a brain tumor drug Temodar. It also developed drugs targeting on central nervous system and the respiratory system. Schering Plough also owned and operated the major foot care brand name Dr. Scholl's and the skin care line Coppertone. These also became a part of the new company. Schering-Plough was a full member of the European Federation of Pharmaceutical Industries and Associations (EFPIA), a membership which is also maintained by the new Merck.

Merck & Co, Inc Careers

Join the visionary team at Merck & Co, Inc, a global leader in healthcare dedicated to advancing the world of medicine. As part of our professional community, you'll find dynamic job opportunities that foster innovation and leadership across various fields. Merck & Co, Inc is not just a company; it's a place where you can make a difference.

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At Merck & Co, Inc, we are committed to improving global health through groundbreaking research and innovative healthcare solutions. Our team is at the forefront of developing new therapies and vaccines that significantly impact public health worldwide. By joining us, you will collaborate with some of the brightest minds in the industry, using your skills to contribute to projects that save and improve lives around the globe.

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We understand that our employees are our greatest asset, which is why we offer competitive benefits designed to support the health and well-being of you and your family. From comprehensive health care coverage and retirement plans to flexible working conditions and wellness programs, our benefits package is designed to meet the diverse needs of our team members.

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Ready to advance your career at Merck & Co, Inc? Search open positions that match your skills and interests. We are continuously hiring and looking for passionate, creative, and solution-driven team players. Prepare your resume, sharpen your interview skills, and become part of a company that's dedicated to making a difference.

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Learn more about Merck & Co, Inc
Size
68,000 employees
Market Cap
$282.6 billion
Industry
Pharmaceuticals & Biotech
Net Income
$7 billion
Founded
1668
5 Year Trend
+4.1%
Revenue
$47.9 billion
NASDAQ
MRK
* Ladders Estimates

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