Pfizer

Senior Scientist, Computational Biotherapeutics Engineering

Pfizer$93K — $156K *
Pharmaceuticals & Biotech
Less than 5 years of experience
Job Overview by Ladders

Qualifications

  • PhD in biochemistry, computational chemistry, computational biology, machine learning, or related field (0-3 years of experience) OR Master's with 7-8 years OR BA/BS with 9-11 years of experience.
  • Track record of applying AI/ML in protein modeling/design, evident in publications or project leadership.
  • Hands-on experience with modern AI/ML models for protein representation or generation.
  • Solid understanding of protein structure and sequence-structure relationships.
  • Proficient in Python, with experience in scientific and machine learning libraries (NumPy/SciPy, scikit-learn, PyTorch).
  • Expertise in analyzing large biological datasets.

Responsibilities

  • Implement advanced AI and ML workflows for protein design in scalable cloud environments.
  • Collaborate on AI/ML model design for antibody development and optimize leads for drug discovery.
  • Stay updated on NLP and ML developments to drive innovative molecular discovery solutions.
  • Provide technical expertise in deep learning for protein design to support discovery teams.
  • Analyze large-scale datasets to correlate protein features with pharmaceutical properties.
  • Communicate complex ideas clearly to technical and non-technical stakeholders.
  • Work with lab teams to enhance computational developability platforms.

Benefits

  • 401(k) plan with matching contributions and additional retirement savings contributions.
  • Paid vacation, holiday, and personal days.
  • Paid caregiver/parental and medical leave.
  • Comprehensive health benefits including medical, prescription, dental, and vision coverage.
  • Relocation assistance may be available based on needs and eligibility.
Full Job Description
What You Will Achieve

Pfizer's BioMedicine Design department is seeking a scientist with expertise in computational AI/ML methods spanning protein modeling, representation learning, and generative model development. You will join a computational team working closely with experimental scientists on discovery and optimization of industry-leading biotherapeutics. You will implement, evaluate, and apply state-of-the-art AI/ML methods to advance biotherapeutic discovery and engineering, integrating new models into scalable discovery workflows and decision-making. By collaborating across departments, you will shape the next generation of AI/ML architectures, training strategies, and evaluation approaches for biotherapeutic design. This role offers the opportunity to directly influence the design of clinical molecules, helping achieve Pfizer's goal of breakthroughs that change patients' lives.

How You Will Achieve It
  • Implement advanced cutting-edge AI and machine learning workflows for computational protein design (including fine-tuning protein language models and generative protein design) in HPC or scalable cloud computing environments
  • Collaborate with machine learning colleagues on the design and training of AI/ML models for antibody developability engineering. Apply these models to optimize leads for antibody drug discovery projects.
  • Stay informed about developments in NLP, ML, and generative AI to create innovative solutions for molecular discovery, design, and optimization to advance therapeutic discovery and development.
  • Serve as a technical expert in deep learning models for protein sequence and structure, supporting discovery teams with AI/ML-driven design strategies.
  • Analyze large-scale sequence, structure, and experimental datasets to learn representations linking protein features to developability and pharmaceutical properties.
  • Communicate complex scientific ideas, model behavior, limitations, and design recommendations to both technical and non-technical audiences, fostering collaborations across multidisciplinary teams.
  • Collaborate with computational and wet lab experts to optimize the computational developability platform, offering both individual and team-based innovative solutions.


Qualifications

Must-Have
  • PhD in biochemistry, computational chemistry, computational biology, machine learning, or a related field with 0 t 3 years of experience OR Master's Degree in biochemistry, computational chemistry, computational biology, machine learning with 7 to 8 years of experience OR BA/BS with 9 to 11 years of experience
  • Demonstrated track record (including publications or equivalent impact) of using AI/ML-driven protein modeling/design to influence project direction and strategy
  • Hands-on experience using and interrogating modern AI/ML models for protein representation, structure prediction, or generation (e.g., transformer or diffusion-based approaches).
  • Strong understanding of protein structure, sequence-structure relationships, and model evaluation.
  • Experience programming in Python and using modern scientific or machine learning libraries (e.g., NumPy/SciPy, scikit-learn, PyTorch), including training and evaluation workflows.
  • Experience working with large biological datasets and bioinformatics resources.


Nice to Have
  • Experience with protein language models (e.g., ESM-family models), generative structure models (e.g., RFdiffusion, BoltzGen, BindCraft), and structural prediction AI models (e.g. AlphaFold)
  • Familiarity with equivariant or structure-aware neural networks.
  • Knowledge of antibody structure, multispecific design, or developability modeling.
  • Experience running and scaling deep learning workloads on HPC/GPU/cloud environments using technologies such as Slurm, AWS, or Google cloud.
  • Experience with structure-based molecular modeling software (Rosetta, Schrödinger, MOE, FoldX)


Work Location Assignment: Hybrid

Hybrid colleagues are required to be onsite or in-person for an average of 2.5 weekdays (Monday to Friday) per week
The annual base salary for this position ranges from $93,600.00 to $156,000.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

About Pfizer

Hospira, Inc. is the provider of injectable drugs and infusion technologies. Through its broad, integrated portfolio, Hospira is uniquely positioned to Advance Wellness™ by improving patient and caregiver safety while reducing healthcare costs. The company is headquartered in Lake Forest, Ill., and has approximately 16,000 employees.

Pfizer Careers

Joining Pfizer’s global team offers more than just job opportunities; it’s a chance to be a part of a company that leads with science and innovates for better health. As a leading biopharmaceutical company, Pfizer is at the forefront of transforming lives through innovation, leadership, and diversity. Work You’ll Do At Pfizer, you will collaborate with some of the brightest minds in the industry, engaging in work that enhances global health and saves lives. Our culture thrives on intellectual curiosity, professional growth, and inclusivity, making every day a learning opportunity. Here, your skills will be honed, your professional acumen will be expanded, and you will be part of a team that values the power of diverse insights to drive success. Pfizer’s Leadership and Growth Lead and innovate with Pfizer, where we value the growth of each employee. Our leadership is committed to providing employees with the training and resources needed to excel in their careers. Pfizer offers a variety of career paths, including roles in research, marketing, finance, technology, and more, each offering a unique blend of challenges and rewards. Internship and Employment Opportunities Start your career with Pfizer through our internship programs or dive straight into a full-time position. We are hiring individuals who are passionate about healthcare and who seek to make a difference in the world. Our internships provide invaluable industry experience, networking opportunities, and a potential pathway to full-time employment. Benefits and Culture Pfizer is dedicated to fostering a workplace where all employees feel valued and can achieve their full potential. We offer competitive benefits packages that support the health, well-being, and financial security of our employees and their families. At Pfizer, you’ll find a culture that encourages collaboration, innovation, and continuous learning. Join Our Team Explore the numerous job opportunities at Pfizer by searching open positions that match your skills and interests. We look for driven, curious, and innovative team players who are ready to advance their careers in a transformative company. Stay Connected Keep up to date with career tips, insider perspectives, and industry-leading insights you can put to use today—all from the people who work here. Personalize your subscription to receive job alerts, latest news, and insider tips tailored to your preferences. Discover the exciting and rewarding career opportunities that await at Pfizer. Interview and Resume Tips Prepare for your future with Pfizer by utilizing our resources for resume building and interview preparation. We provide guidance on how to effectively showcase your skills and experiences to align with the needs of a position at Pfizer. Our goal is to help you succeed in securing a role that suits your professional goals and personal growth aspirations. Pfizer: A Place Where You Can Make a Difference Every position at Pfizer contributes to our mission of making the world a healthier place. Whether through direct patient care, research innovation, or corporate roles that support our operations, your work will have global impact. Join us in our journey to change lives—explore Pfizer careers today.
Learn more about Pfizer
Size
79,000 employees
Market Cap
$285.9 billion
Industry
Net Income
$9.6 billion
Founded
1849
5 Year Trend
+9%
Revenue
$41.9 billion
NASDAQ

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