Overview:

Analytical Development at Alnylam is seeking a highly motivated Senior Scientist with expertise in Bioassay including cell-based assays using different cell types and detection formats, qPCR, ELISA . This role involves performing non-GMP in-house Bioassay method development, testing while supporting and overseeing method development , GMP testing at external laboratories. In this role, you will be an individual contributor.

This is a full time, onsite position based in Cambridge, MA.

Responsibilities:

• Perform and oversee cell based assays including ELISA and qPCR as well as microbiology tests.
• Lead feasibilities, development and transfers for cell based assays internally and externally, building and maintaining key relationships at CTLs.
• Apply deep knowledge of regulatory guidelines (ICH, USP chapters) to ensure compliance in bioassay development and validation as well as data verification.
• Provide bioassay technical leadership within assigned programs and offer guidance across other programs as needed.
• Draft, review and/or approve protocol, reports, certificates of testing.
• Record results of analysis in electronic notebook and/or in appropriate documentation method.
• Participate in cross-functional training and facilitate continuous improvement.
• Provide training and mentorship to colleagues and junior scientists within this area of expertise.

Qualifications:

• Ph.D. in a scientific discipline with 5 years of experience in biotechnology or pharmaceutical laboratory is required.
• Strong expertise including hands-on experience with cell-based assays, ELISA, and qPCR.
• Experience with microbiological tests preferred.
• Robust understanding of regulatory guidance and industry standards relevant to bioassay related CMC activities, particularly in the development and validation of bioassays.
• Strong scientific, analytical problem solving and communication skills are required.
• Demonstrate adaptability and a willingness to support changing priorities and evolving departmental needs
• Highly organized, detail-oriented and computer proficiency to handle related scientific tasks.
• Ability to work independently in a fast pace work environment and prioritize several projects with minimal supervision.
• Flexibility to travel to CTLs\CMOs on an as needed basis.

#LI-KB1 #LI-Onsite

U.S. Pay Range

$137,700.00 - $186,300.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

About Alnylam

We are the leader in RNAi therapeutics - a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.