Kymera Therapeutics

Senior Manager or Associate Director, Translational Medicine Operations

Kymera Therapeutics • $145K — $240K *
Watertown, MA 02472In-Person
Pharmaceuticals & Biotech
5 - 7 years of experience
Today
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Job Overview by Ladders

Qualifications

  • 7-10+ years in Translational Medicine Operations or related drug development roles
  • Bachelor's degree in Life Sciences or a related field required
  • Demonstrated experience managing biospecimen operations for Phase I-III trials
  • Proficiency in managing central laboratories and external vendors
  • Experience developing operational documents for biospecimen handling
  • Strong understanding of clinical trial operations and regulations
  • Excellent project management skills in a fast-paced environment

Responsibilities

  • Lead Translational Medicine operations for clinical studies involving biospecimen management
  • Develop and execute strategies for biospecimen collection and tracking
  • Manage operations with central laboratories and vendor partners
  • Collaborate with cross-functional teams for biomarker and biospecimen execution
  • Support site readiness and ongoing investigator training
  • Monitor and ensure biospecimen quality and data integrity
  • Proactively identify risks and manage operational issues for studies

Benefits

  • Comprehensive benefits package
  • Opportunities for performance-driven bonuses and equity participation
  • Supportive work environment fostering team development
  • Access to cutting-edge projects in biotechnology
  • Ongoing professional development and career advancement opportunities
Full Job Description


How you'll make an impact:
  • Lead Translational Medicine (TM) operations for clinical studies, overseeing end-to-end biospecimen management from study start-up through closeout.
  • Develop and execute biospecimen operational strategies, including collection, processing, handling, shipment, tracking, reconciliation, and archival activities.
  • Manage central laboratory and vendor operations, including study setup, contract management, laboratory documentation, assay support, kit management, and performance oversight.
  • Partner cross-functionally with Translational Medicine, Clinical Operations, Biomarker Scientists, CROs, CRUs, and external vendors to ensure successful execution of biomarker and biospecimen activities.
  • Oversee site operational readiness by supporting study start-up, investigator site training, biospecimen collection procedures, and ongoing site issue resolution.
  • Monitor biospecimen quality and data integrity by managing sample deviations, resolving operational issues, conducting root cause analyses, and implementing corrective and preventive actions.
  • Lead operational execution for complex, multi-site clinical studies by proactively identifying risks, managing escalations, and implementing mitigation strategies to ensure study timelines and objectives are achieved.
  • Ensure compliance with study protocols, regulatory requirements, and company standards while driving continuous process improvements across Translational Medicine operations.


Skills and experience you'll bring:
  • 7-10+ years of experience in Translational Medicine Operations, Clinical Sample Management, Biomarker Operations, or a related drug development function within the biotechnology, pharmaceutical, or CRO industry.
  • Bachelor's degree in Life Sciences, Biology, Biomedical Sciences, Clinical Laboratory Science, or a related discipline required.
  • Advanced degree (MS, MPH, or PhD) preferred but not required.
  • Demonstrated experience managing end-to-end biospecimen operations for Phase I-III clinical trials, including sample collection, processing, shipment, tracking, reconciliation, and study closeout.
  • Proven ability to manage central laboratories, specialty laboratories, and external vendors, including study start-up, laboratory manual review, kit management, performance oversight, and issue resolution.
  • Experience developing biospecimen operational documents such as laboratory manuals, sample management plans, collection guidelines, and processing instructions.
  • Strong understanding of clinical trial operations and collaboration with Clinical Operations, CROs, clinical sites, and Clinical Research Units (CRUs).
  • Experience overseeing vendor contracts, scopes of work, budgets, and cross-functional partnerships with Legal, Procurement/Sourcing, and Finance.
  • Experience managing sample deviations and ensuring sample and data integrity.
  • Knowledge of GCP, ICH guidelines, biospecimen chain of custody, sample handling best practices, and applicable regulatory requirements.
  • Experience using sample tracking systems, Smartsheet, or similar operational tools.
  • Excellent project management skills with the ability to prioritize multiple studies, manage timelines, identify risks, and drive cross-functional alignment.
  • Experience working in a fast-paced biotechnology environment with evolving clinical development programs.
  • Demonstrated experience leading, developing, and mentoring high-performing teams, including direct people management and performance development.
  • Experience leading cross-functional teams and influencing stakeholders in a matrixed organization without direct reporting authority.
  • Experience supporting early-phase (Phase I/II) immunology, where translational endpoints are a major focus. (Preferred)
  • Experience with pharmacodynamic assays, flow cytometry, genomics, transcriptomics, IHC or other biomarker platforms. (Preferred)
  • Familiarity with assay validation activities and laboratory technology transfers. (Preferred)


Compensation
  • Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
  • The anticipated base salary range for this role is $145,000 - $240,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
  • Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate's depth of experience and the capabilities they bring to the position.

About Kymera Therapeutics

Kymera Therapeutics is a clinical-stage biopharmaceutical company that is focused on discovering and developing novel small molecule therapeutics that selectively degrade disease-causing proteins by harnessing the body's own natural protein degradation system. The company's proprietary targeted protein degradation platform, Pegasus, is designed to harness the body's natural protein recycling machinery to degrade disease-causing proteins, with a focus on undruggable and difficult-to-drug targets. Kymera's initial programs are focused on oncology and immunology, with a goal of delivering transformative therapies for patients with previously untreatable diseases. Kymera was founded in 2015 and is headquartered in Cambridge, MA.
Learn more about Kymera Therapeutics
Size
75 employees
Market Cap
$1.4 billion
Industry
Pharmaceuticals & Biotech
Founded
2017
NASDAQ
KYMR
* Ladders Estimates

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