Job Function: Discovery & Pre-Clinical/Clinical Development
Job Sub Function: Biotherapeutics R&D
Job Category:People Leader
All Job Posting Locations:Spring House, Pennsylvania, United States of America
Job Description:We are searching for the best talent for a
Senior Manager, Biotherapeutics R&D, to be based on-site in Spring House, PA.
Purpose:We are seeking an accomplished scientific leader to define and advance our next-generation immunotherapy design strategy. Reporting to the Executive Director of Biologics Design and Function, this role will shape scientific direction, drive execution, and identify differentiated therapeutic opportunities grounded in deep biological insight and translational relevance. This is not a project management role; it is an opportunity to tackle one of the most important unsolved challenges in biologics and build a new therapeutic capability for the company.
As a key scientific leader within our R&D organization, the Senior Manager will help shape future research priorities with senior leadership, deepen understanding of differentiated therapeutic concepts tied to critical patient needs, identify and integrate emerging technologies, and recruit, develop, and inspire exceptional scientific talent. The role also requires disciplined delivery against ambitious discovery pipeline goals, balancing innovation, scientific rigor, and resource stewardship.
You will be responsible for:- Own the scientific strategy and execution for next-generation platforms designed to create differentiated medicines across immunology, oncology, and adjacent disease areas.
- Lead multidisciplinary teams spanning discovery biology, protein design/optimization, translational sciences, computational biology, pharmacology, and therapeutic area expertise to advance programs from concept through candidate selection.
- Drive the creation of novel therapeutic architectures that selectively recruit and program immune responses against disease-driving biology.
- Define and implement molecular strategies that enhance therapeutic activity while regulating biological response and expanding therapeutic index.
- Translate advances in immunology, systems biology, synthetic biology, computational sciences, and protein engineering into actionable therapeutic opportunities and platform capabilities.
- Maintain end-to-end ownership of scientific decisions that influence molecule performance, differentiation strategy, and long-term portfolio value.
- Identify and resolve critical biological and engineering bottlenecks affecting efficacy, safety, developability, and translational potential.
- Convert complex and ambiguous scientific questions into executable research strategies, measurable milestones, and portfolio decisions.
- Drive rapid hypothesis generation, experimental learning cycles, and evidence-based decision-making across programs.
- Mentor and develop high-performing scientists while fostering a culture of scientific rigor, curiosity, accountability, and bold thinking.
- Build teams that challenge assumptions and pursue bold ideas while maintaining strong execution discipline.
Qualifications:Required- PhD, MD/PhD, or equivalent in immunology, cell biology, molecular biology, bioengineering, or a related discipline.
- Typically 8+ years of relevant research experience in biotechnology, biopharma, or leading translational academic environments.
- Deep expertise in immune cell biology and the mechanisms governing cellular activation, signaling, differentiation, and functional response.
- Demonstrated success advancing biologic therapeutics from discovery through candidate selection.
- Strong understanding of translational pharmacology, disease biology, and mechanisms of therapeutic differentiation.
- Proven ability to lead multidisciplinary scientific teams in complex, matrixed research environments.
Preferred- Experience with multispecific therapeutic modalities, immune-engaging platforms, or engineered signaling systems.
- Expertise spanning multiple immune cell populations, including innate and adaptive immune biology.
- Experience in mechanistic assay development, human translational systems, and biomarker strategy.
- Strong publication, patent, and/or drug discovery track record.
- Demonstrated ability to translate frontier science into differentiated therapeutic opportunities and platform value.
What Exceptional Candidates Often Bring- The ability to connect first-principles biology with therapeutic design.
- Systems-level thinking rather than target-level thinking.
- Comfort operating where data are incomplete and scientific frameworks are still emerging.
- The ability to convert novel scientific concepts into scalable platforms and long-term portfolio value.
- The curiosity to pursue important questions not yet fully defined by the field.
Why This Role MattersThe future of medicine may depend not only on discovering individual targets, but on learning how to direct biological systems with precision. This role will help define how immune systems can be programmed to recognize, engage, and eliminate disease while preserving the balance required for safe, durable patient benefit.
Required Skills: Preferred Skills:Analytical Reasoning, Biochemistry, Chemistry, Manufacturing, and Control (CMC), Clinical Research and Regulations, Clinical Trial Designs, Developing Others, Drug Discovery Development, Inclusive Leadership, Leadership, Molecular Diagnostics, Pharmacovigilance, Process Improvements, Productivity Planning, Program Management, Quality Assurance (QA), Scientific Research, Tactical Planning, Team Management, Troubleshooting
