Job Function: Discovery & Pre-Clinical/Clinical Development
Job Sub Function: Pharmacokinetics & Pharmacometrics
Job Category:Scientific/Technology
All Job Posting Locations:San Diego, California, United States of America, Spring House, Pennsylvania, United States of America
Job Description:Purpose: The Senior Principal Scientist will be a key member of discovery project teams and interact closely with biology, chemistry, and other drug metabolism and pharmacokinetic (DMPK) project members to help craft the most appropriate preclinical and early clinical studies and the associated quantitative model-based analyses to advise candidate selection and dosing recommendations. Modeling approaches used may include physiologically-based pharmacokinetic modeling, mechanistic PK/PD modeling, and/or systems pharmacology modeling to help (a) predict preclinical and clinical PK profiles (b) quantify exposure/ response relationships for target engagement biomarkers, efficacy, and potential adverse effects, and (c) guide in vivo and in vitro experimental designs that will be most informative for modeling.
We are searching for the best talent for a Senior Principal Scientist, Preclinical Safety & Translational Sciences-Translational Pharmacokinetics/Pharmacodynamics to be located in Spring House, PA or La Jolla, CA. You will be responsible for:- Applying Pharmacokinetic/Pharmacodynamic (PK/PD) modeling to drive project team decisions from early discovery through early clinical studies.
- Contributing to guide modeling and simulation strategies within the organization.
Qualifications / Requirements:Education:- PhD in Pharmacology, Engineering, Mathematics, Physics, or a related field with 6+ years of relevant industry experience OR a Master's degree with 8+ years of relevant industry experience is required.
Experience and Skills:- Strong familiarity with principles of pharmacokinetics and pharmacodynamics and experience performing PK and/or PK/PD modeling is preferred.
- Proven skills in mathematical modeling and simulation, supported by peer-reviewed publications is highly desired.
- Excellent interpersonal, organizational, oral/written communication and teamwork skills are required.
#LI-Hybrid
Required Skills:Preferred Skills:Clinical Pharmacology, Clinical Trials Operations, Consulting, Drug Discovery Development, Industry Analysis, Pharmacodynamics, Pharmacokinetics, Pharmacology, Pharmacometrics, Program Management, Report Writing, Researching, Research Proposals, Scientific Research, Tactical Planning, Technical Credibility
The anticipated base pay range for this position is :$137,000.00 - $235,750.00
Additional Description for Pay Transparency:
Subject to the terms of their respective plans, employees are eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)).
Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits:
Vacation -120 hours per calendar year
Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado -48 hours per calendar year; for employees who reside in the State of Washington -56 hours per calendar year
Holiday pay, including Floating Holidays -13 days per calendar year
Work, Personal and Family Time - up to 40 hours per calendar year
Parental Leave - 480 hours within one year of the birth/adoption/foster care of a child
Bereavement Leave - 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
Caregiver Leave - 80 hours in a 52-week rolling period10 days
Volunteer Leave - 32 hours per calendar year
Military Spouse Time-Off - 80 hours per calendar year
Additional information can be found through the link below.
For additional general information on Company benefits, please go to: - https://www.careers.jnj.com/employee-benefits
