Job Description

General Summary:

Vertex is seeking a talented individual to join the Engineering and Materials Science department in Boston, MA. The successful candidate will be a productive, results-oriented leader who is able to lead a diverse team of engineers and scientists and contribute to the successful development and scale-up of drug substance and drug product candidates. Excellent leadership, interpersonal, and organization skills as well as a high level of technical aptitude and creativity are required for success in this position.

Key Duties and Responsibilities:

• Be responsible for leading and developing a cross-functional team of engineers and scientists in defining, developing, and demonstrating viable, multi-step syntheses for the robust manufacture of small-molecule or oligonucleotide active pharmaceutical ingredients, spanning all phases of clinical development through to commercialization and launch
• Lead drug substance process development efforts and apply sound scientific judgement to drive multiple assets in a fast-paced environment via laboratory development, modeling, drug supply preparation, and technology transfer to third party manufacturing facilities
• Collaborate with materials discovery, process chemistry, analytical development, and formulation groups to improve the overall discovery/development process for definition and optimization of drug substance properties and performance across the clinical development spectrum
• Drive the adoption of process modeling within the department.
• Potentially lead projects, representing all aspects of pharmaceutical sciences
• Be at the forefront of industry best practices and promote innovation.
• Be vested in developing team members and technically mentoring junior-level scientists
• Influence departmental strategic direction
• Use excellent communication and interpersonal skills to influence stakeholders and interact, lead, and collaborate within an interdisciplinary team comprised of chemical engineers, organic, physical, and analytical chemists, materials and solid-state scientists, and formulation development personnel

Knowledge and Skills:

• Experience leading a team of engineers/scientists in pharmaceutical process development
• Advanced knowledge of standard unit operations encountered in small molecule and/or Oligonucleotide drug substance process development inclusive of particle engineering, reaction kinetics, thermodynamics, and transport fundamentals
• Have demonstrated experience with modeling complex, physicochemical systems, data analysis, statistical design of experiments, QbD concepts, and fluency with common physical property and process modeling tools
• Demonstrated process scale up and regulatory dossier authoring.
• Experience with process development and problem solving in a matrix environment
• Strong communication skills and the ability to influence both stakeholders and team members

Education and Experience:

• A BS (+ 20 years), MS (+ 15 years) or PhD (+ 11 years) in Materials Science/Chemistry, or a closely related field, with relevant pharmaceutical materials development experience

• 5 years experience managing a team

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Pay Range:

Disclosure Statement:

Flex Designation:

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex99s Policy on Flex @ Vertex Program and may be changed at any time.

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