ROLE SUMMARY

We are seeking a synthetic organic chemist to join the Process Chemistry group within Chemical Research and Development (CRD) in Groton, CT. CRD, part of Preclinical and Translational Sciences within Pfizer R&D, is responsible for the development of process technology to produce active pharmaceutical ingredients (APIs). This work includes the synthesis of diverse chemical entities that support both traditional small molecules and emerging therapeutic modalities, including peptides, lipids and other complex synthetic molecules. CRD scientists engage in all facets of development from small scale synthesis in support of discovery programs, to the development of the commercial synthetic routes. CRD scientists partner with manufacturing specialists for API synthesis in kilo-lab and pilot plant facilities, as well as provide support for technology transfer to Pfizer manufacturing sites and third-party facilities.

The successful candidate will enable and develop scalable processes to pharmaceutical drug candidates which are safe, efficient and robust through thoughtful experimentation in a laboratory setting. The ability to work on multi-disciplinary teams involving chemists, analysts, engineers, and technologists is essential.

ROLE RESPONSIBILITIES

The successful candidate will work in the laboratory and assist in the design and execution of synthetic routes to drug candidates including traditional small-molecules, peptides, lipids, and other complex synthetic modalities, within a dynamic, team-oriented environment and assist in the development and completion of experimental studies to provide safe, efficient, robust and scalable processes.

A strong working knowledge of synthetic organic chemistry principles, excellent laboratory skills, an awareness of analytical methods, and a commitment to safety are required.   Compliance on safety and regulatory requirements is expected and documented through our internal training program.

The candidate should thrive in the collaborative environment of a multi-disciplinary project team.

A willingness to learn and apply new technology to process development challenges is required.

QUALIFICATIONS

• Master’s degree in Chemistry with laboratory-based research experience required. Pharmaceutical industry experience is preferred but not required.

• Demonstrated high performance in synthetic organic chemistry experimentation with a strong working knowledge of synthetic organic chemistry principles.

• Excellent oral and written communication skills, including the ability to maintain an accurate scientific notebook.

• Familiarization with modern analytical tools and techniques, as well as data interpretation.

• Thorough working knowledge of the published literature in synthetic organic chemistry.

• An ability to communicate results through clear, concise written reports, publications and related documentation.

• Prior experience with peptide and lipid synthesis is highly valued, particularly hands-on experience with route development, scale-up, purification strategies, and cross-functional collaboration in support of pharmaceutical research and development, though it is not required.

PHYSICAL/MENTAL REQUIREMENTS

Laboratory work requires standing.

Working at a computer.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

Travel is required on occasion in support of external manufacture or to participate in scientific conferences.

Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

Research and Development