Senior Associate Scientist, Medicinal Chemistry

Overview

We are seeking a talented and passionate scientist to join our dynamic, fast-paced, and collaborative team. Using strong organic synthesis skills, you will contribute to developing and supporting novel chemistry solutions for the advancement of our RNAi platform. The successful candidate will have a strong background in synthetic Organic Chemistry with a creative mindset, independent problem-solving ability, and desire to enable discoveries at the bench.

This position is onsite and will be primarily located in Cambridge, MA.

Key Responsibilities

• Develop and execute syntheses of novel chemical modifications and delivery modalities for siRNA
• Multi-step synthesis, purification, and structural analysis of intermediate compounds
• Synthesis of organic building blocks to be used for RNA delivery
• Work closely with our internal RNAi platform teams and external collaborators to discuss project plans and coordinate activities for delivery and activity determination of siRNA
• Troubleshoot and perform routine maintenance on critical instrumentation such as NMR, HPLC, LCMS and other instruments in the lab
• Analyze, interpret, and organize data to prepare clearly articulated experimental reports and communicate the results of the projects at internal meetings

Qualifications

• The ideal candidate will have a B.S./M.S. in Chemistry and 2-3 years of industrial experience in Medicinal Chemistry
• Demonstrated ability to understand reaction mechanism and chemical reactivity in Organic Chemistry is a must
• Strong laboratory skills in synthesis, purification, and characterization of small molecules
• Expertise in state-of-the-art analytical techniques such as LC, MS, NMR, and the ability to analyze, interpret, and present data are a prerequisite
• Must be flexible to be able to apply her/his knowledge to new areas of study, thrive in a team environment, and possess excellent communication skills (both written and oral)

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U.S. Pay Range

$80,000.00 - $120,000.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers