The Lead Discovery and Optimization Group within Therapeutic Discovery Sciences in San Diego focuses on delivering novel therapeutics for disease intervention by engaging E3 ubiquitin ligases for targeted protein degradation. We seek a highly driven senior associate scientist to help identify and characterize drug candidates for the treatment of human diseases. The successful candidate will work collaboratively in a multi-disciplinary environment to carry out cell-based and molecular assays in support of small molecule discovery for pre-clinical development.
Responsibilities will include but are not limited to the following:
Design and implementation of high-throughput cell-based reporter assays to characterize drug candidates
Establish stable cell lines via lentiviral transduction and maintain mammalian cell lines
Conduct routine molecular and cellular experiments including DNA/RNA/protein extraction, immunoblot analysis, and immunoprecipitation
Utilize Python, R, or similar programming languages to analyze, interpret, visualize, and communicate complex scientific data, applying advanced analytical techniques to generate actionable insights and support data-driven decision-making
Assist senior researchers in executing, conducting analyses, and reporting results of experiments
Familiarity with literature and internal best practices to identify opportunities to improve productivity and quality of work
Analyze, troubleshoot, and recommend corrective actions for routine problems
Maintain an accurate, comprehensive, and current laboratory notebook
Write protocols, procedures, and technical reports
Communicate results via written reports and oral presentations
Basic Qualifications:
Or
Or
Preferred Qualifications:
Expertise in mammalian cell culture, plate-based cellular assays, immunoblotting, lentiviral infection, cellular transfection, and basic molecular biology techniques
Experience with medium and high-throughput screening is highly preferred
Experience with targeted protein degradation assay is a plus
Familiarity with automation instruments and multi-mode plate readers
Demonstrated proficiency in Python, R, or similar programming languages, with the ability to apply advanced analytical techniques to interpret, visualize, and communicate meaningful results
Outstanding problem-solving and organization skills.
Effective team player and strong individual contributor
Self-driven, flexible, pragmatic, and able to handle multiple tasks while delivering high quality data
Effective communication skills, both verbal and written
#li-onsite
If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
San Diego - CA - US: $118,750 - $143,901
The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.
Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit
Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:
Health Coverage: Medical, pharmacy, dental, and vision care.
Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
Work-life benefits include:
Paid Time Off
US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.
*Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.
Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol
BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
