Eurofins Lancaster Laboratories

Scientist - Molecular Cloning & Automation

Eurofins Lancaster Laboratories • $93K — $99K *
Boston, MA 02115In-Person
Pharmaceuticals & Biotech
Less than 5 years of experience
Today
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Job Overview by Ladders

Qualifications

  • B.S. with 5+ years, M.S. with 3+ years, or Ph.D. with 2+ years in Molecular Biology, Biochemistry, Bioengineering, or related field.
  • Expert proficiency in Golden Gate, Gibson Assembly, and restriction-ligation cloning techniques.
  • Strong knowledge of plasmid biology, including origins of replication and promoter design.
  • Hands-on PCR experience with polymerase selection and troubleshooting.
  • Experience managing CRO/vendor relationships for gene synthesis or cloning.
  • Familiarity with Benchling or similar ELN for construct tracking.
  • Proficiency in sequence design and visualization tools.

Responsibilities

  • Design and execute plasmid workflows from sequence to production-ready constructs.
  • Select and apply advanced cloning strategies based on construct complexity.
  • Develop, implement, and scale automated workflows for plasmid production.
  • Establish and manage tiered QC pipelines for construct validation.
  • Oversee CRO/vendor relationships for outsourced cloning and gene synthesis.
  • Partner with cross-functional teams to manage construct delivery and timelines.

Benefits

  • Comprehensive medical, dental, and vision coverage.
  • Life and disability insurance.
  • 401(k) with company match.
  • Paid vacation and holidays.
Full Job Description
Job Description

We are seeking a skilled Scientist - Molecular Cloning & Automation to lead plasmid design, DNA assembly, and scalable workflow development. You will apply advanced cloning strategies and build automated solutions to support high-throughput construct generation, ensuring quality, efficiency, and on-time delivery across multiple programs.

Job Responsibilities
  • Design and execute end-to-end plasmid workflows, translating protein or guide RNA sequences into verified, production-ready constructs
  • Select and apply appropriate cloning strategies (e.g., Golden Gate, Gibson Assembly, restriction-ligation) based on construct complexity
  • Develop, implement, and scale automated workflows for high-throughput plasmid production, including:
    • Liquid handling platforms (Hamilton STAR, Opentrons, Beckman Biomek)
    • Automated colony picking systems (e.g., QPix)
    • High-throughput miniprep processes
  • Establish and manage tiered QC pipelines (colony PCR, restriction digest, Sanger and/or long-read sequencing) while maintaining accurate construct documentation
  • Oversee CRO and vendor relationships for outsourced cloning and gene synthesis, including construct submission, timeline management, and QC review
  • Partner cross-functionally to deliver constructs on time, managing multiple concurrent requests with clear, proactive communication


Qualifications

Required Qualifications:
  • B.S. with 5+ years, M.S. with 3+ years, or Ph.D. with 2+ years of relevant industry experience in Molecular Biology, Biochemistry, Bioengineering, or a related field
  • Expert proficiency in Golden Gate, Gibson Assembly, and restriction-ligation cloning, with the ability to select optimal strategies
  • Strong knowledge of plasmid biology, including origins of replication, selection markers, promoter design, codon optimization, and management of recombination-prone sequences
  • Hands-on PCR experience, including polymerase selection (e.g., Q5, Phusion), primer design, and troubleshooting challenging amplicons.
  • Experience managing CRO/vendors for gene synthesis or outsourced cloning
  • Proficiency with Benchling or similar ELN for construct tracking and QC documentation
  • Familiarity with sequence design and visualization tools (e.g., SnapGene, Geneious)
  • Proven ability to manage multiple simultaneous cloning projects and deliver high-quality constructs on timeline
  • Strong communication skills with a collaborative, cross-functional mindset

Preferred Qualifications:
  • Experience programming, validating, and troubleshooting liquid handling platforms (e.g., Hamilton, Beckman, Tecan, Opentrons)
  • Familiarity with automated colony picking and high-throughput plasmid prep workflows
  • Experience with pooled oligo cloning, including library design, bias mitigation, and NGS-based QC analysis
  • Background in lentiviral or pooled library cloning workflows
  • Experience with long-read sequencing technologies (PacBio or Nanopore)
  • Exposure to gene therapy applications (AAV, LVV, mRNA, CAR-T) and downstream construct use
  • Experience supporting IVT template design or mRNA production workflows
  • Authorization to work in the U.S. without sponsorship


Additional Information

What to Expect in the Hiring Process:
  • 10-15 Minute Phone Interview with Region Recruiter
  • 45-60 Minute Virtual Interview with Manager and/or Group Leader
  • 30 Minute In-Person Onsite Meeting with the Team

Additional Details:

The position is Full Time, Monday-Friday, 8am-5pm. Candidates currently living within a commutable distance of Boston, MA are encouraged to apply.

Excellent full-time benefits include:
  • Comprehensive medical coverage, dental, and vision options
  • Life and disability insurance
  • 401(k) with company match
  • Paid vacation and holidays
  • Hourly rate is between $45.00-$48.00, depending on education and experience

About Eurofins Lancaster Laboratories

Eurofins Lancaster Laboratories is a leading contract research organization (CRO) providing analytical, research and testing services to clients in the pharmaceutical, biopharmaceutical, biotechnology, crop protection, chemical, food, environmental and consumer products industries. The company was founded in 1961 and has grown to become one of the largest CROs in the world, with over 50 locations in 20 countries. Eurofins Lancaster Laboratories is part of the Eurofins Scientific Group, a global leader in bioanalytical testing and laboratory services. The company's services include method development and validation, stability testing, quality control testing, and regulatory compliance support.
Learn more about Eurofins Lancaster Laboratories
Size
12,000 employees
Industry
Pharmaceuticals & Biotech
* Ladders Estimates

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