How You Will Achieve More:

We are seeking a Scientist to join our Translational Medicine group, focused on discovery proteomics to identify and characterize biomarkers and profile immune recognition of therapeutic candidates. The ideal candidate will bring hands-on mass spectrometry expertise across biomarker discovery workflows and immunopeptidomics, with experience in top-down or native protein mass spectrometry considered a strong plus. This is a hands-on, laboratory-based role where your data will directly inform how we evaluate and advance our therapeutic candidates.

Responsibility:

• Design and execute discovery proteomics workflows — including sample preparation, LC-MS/MS data acquisition, and downstream bioinformatic analysis — to identify and characterize candidate biomarkers across biological matrices.
• Develop and run immunopeptidomics workflows, from MHC class I/II immunoaffinity purification through peptide elution, cleanup, and nanoflow LC-MS/MS, to profile HLA-presented peptides and characterize immune recognition of therapeutic candidates.
• Analyze complex proteomics and immunopeptidomics datasets using specialized search software and bioinformatic tools, translating results into clear, actionable insights.
• Apply top-down and/or native mass spectrometry approaches, where relevant, to characterize protein higher-order structure, complex integrity, and post-translational modifications (a valued but not required skill set).
• Select and optimize separation chemistry and MS platforms best suited to each analyte and biological question.
• Plan and lead well-defined assay development and discovery projects end-to-end, independently identifying the broader objectives each project should address.
• Author assay methods, SOPs, and bioanalytical/risk assessment reports, and partner closely with immunology, process development, and other cross-functional teams to communicate findings.

About You:

• Hands-on experience with immunopeptidomics workflows, including MHC/HLA immunoprecipitation and low-abundance peptide LC-MS/MS
• Experience with native and/or intact protein mass spectrometry
• Familiarity with HLA-binding prediction tools and immunopeptidomics-specific proteomics search software
• Strong bioanalytical and structural mass spectrometry background
• Strong problem-solving skills, with the ability to apply in-depth theoretical knowledge to complex technical challenges within a defined scientific area
• Ability to execute studies, manage outlined timelines, and ensure data quality
• Ability to draw conclusions from experimental results and apply them to new experiments
• Excellent organizational, written, and verbal communication skills
• Strong interpersonal skills and the ability to prioritize effectively across competing demands
• Comfortable operating in a fast-paced, deadline-driven environment
• PhD in a biological or relevant technical/engineering field, or equivalent through a combination of education and experience
• 0–3+ years of relevant experience post-PhD (or 6–9+ years with an MS, or 8–11+ years with a BS)
• Must be able to lift up to 15 pounds at times.
• Prolonged periods of sitting at a desk and working on a computer.

#LI-Onsite

Applications are accepted on a rolling basis, and will continue to be accepted until the position is filled at which point the position will be taken down.

The salary offered is determined based on a range of factors including, but not limited to, relevant education and training, overall related experience, specialized, rare or in-demand skill sets, internal comparators and other business needs. Upon joining Intellia, your salary will be reviewed periodically and additional factors such as time in role and performance will be considered. Intellia may change the published salary range based on company and market factors.

Additional compensation includes a performance-based annual cash bonus, a new hire equity grant, and eligibility to be considered for annual equity awards the value of which are determined annually at the Company’s discretion.

For more information about Intellia’s benefits, please .