Scientist I - Single-cell genomics and bioinformatics - Molecular GeneticsThe
Molecular Genetics department at the Allen Institute for Brain Science defines cell types in the mouse nervous system with single-cell genomics techniques and generates high-precision genetic tools to effectively identify, monitor, and manipulate distinct neuronal cell types.
We seek an exceptional
Scientist I who will work in the Molecular Genetics department on analysis of single-cell transcriptomics and spatial transcriptomics data in the peripheral nervous system. The candidate should have an exceptionally strong background in bioinformatics and single-cell genomics. They will work closely with team members to analyze various types of single-cell genomics data to define neuronal types, interrogate functional connectivity, and help design genetic tools to access these cell types. This individual should be highly efficient, capable of working independently, and collaborative. This individual will be an excellent communicator, efficient in both independent work and collaborations with others.
Essential Functions - Support initiatives across the Allen Institute for Brain Science, Allen Institute for Neural Dynamics and Allen Institute for Immunology to create reference atlases for cells in the peripheral nervous system using single-cell genomic data
- Apply and adapt existing computational and experimental approaches to integrate gene expression and epigenetic information from a variety of single-cell genomic datasets
- Collaborate with team members to interpret biological findings from data and contribute ideas for follow-up experiments, gaining independence and autonomy over time
- Learn and apply analytical methods for defining cell types and predicting enhancer activity from single-cell data and for supporting the development of genetic tools that mark distinct functional or anatomical cell types
- Contribute to computational method development for single-cell genomics, under the guidance of team leads
- Present research findings regularly to internal team members and stakeholders; contribute to the preparation of manuscripts, grant proposals, and external presentations
Note: Reasonable accommodations may be made to enable individuals with disabilities to perform essential functions. This description reflects management's assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned.
Required Education and Experience - Ph.D. in Bioinformatics, Genomics, Neuroscience or related field; or equivalent combination of degree and experience
- Demonstrated experience with single-cell genomics analysis or large-scale data analysis
- Proficiency in programming languages and tools (R, Python, cloud computing)
- Proficiency in AI tool use, and interest in AI tool development
Preferred Education and Experience - Experience in reproducibly analyzing large single-cell and spatial genomics (transcriptomics, epigenomics, proteomics) datasets
- Experience integrating spatial data with single-cell genomics approaches
- Ability to work independently and within a collaborative, multi-disciplinary environment to meet demanding timelines
- Positive attitude, self-motivated, and demonstrated ability to creatively troubleshoot
- Proven strong publication record
- Knowledge of mouse molecular genetics, neuroscience, and neuroanatomy
- Exceptional oral and written communication and organizational skills
Physical Demands - Fine motor movements in fingers/hands to operate computers and other office equipment
Position Type/Expected Hours of Work - This role is currently able to work both remotely and onsite in a hybrid work environment. We are a Washington State employer, and the primary work location for all Allen Institute employees is 615 Westlake Ave N.; any remote work must be performed in Washington State.
Travel - Attendance and participation in national and international conferences is required
Additional Comments - **Please note, this opportunity offers relocation assistance**
- **Please note, this opportunity may offer work visa sponsorship**
Annualized Salary Range * Final salary depends on required education for the role, experience, and level of skills relevant to the role, along with work location, where applicable.
Benefits - Employees (and their families) are eligible to enroll in benefits per eligibility rules outlined in the Allen Institute's Benefits Guide. These benefits include medical, dental, vision, and basic life insurance. Employees are also eligible to enroll in the Allen Institute's 401k plan. Paid time off is also available as outlined in the Allen Institute's Benefits Guide. Details on the Allen Institute's benefits offering are located at the following link to the Benefits Guide: https://alleninstitute.org/careers/benefits.
