Job Summary:
We are seeking a scientist who is passionate about deploying chemical proteomics to interrogate biology and identify novel opportunities for small molecule drug discovery. The successful candidate will have hands-on experience in mass-spectrometry-based proteomics and chemical biology workflows to characterize the interaction of small molecule ligands with their protein targets. This position will be responsible for supporting efforts to enable ligand discovery against high-impact targets using a combination of proteomic, cellular and biochemical methods.
Requirements
Education and Experience requirements:
- Ph.D. (or equivalent experience) in mass-spectrometry based proteomics or chemical biology
- Experience operating and maintaining orbitrap mass spectrometers and associated nano-LC systems
- Demonstrated experience in acquiring, analyzing and interpreting proteomics datasets and familiarity with common MS software suites
- Experience preparing samples for MS analysis utilizing workflows that include peptide enrichment, protein enrichment or PTM enrichment
- Proficiency in mammalian cell culture, including cell line maintenance, transient transfections, stable cell line generation
- Understanding of cell-based assays for characterization of the functional effects of tool compounds on biological pathways, protein-protein interactions, and cellular proliferation
Key Attributes:
- Excellent communication and presentation skills within a setting of cross-functional program teams
- Ability to prioritize tasks and manage time effectively in a dynamic, fast-paced research environment
- Attention to detail and good organization and documentation habits
- Self-motivated problem solver with a strong sense of independently developing experimental strategies to address key needs
Pay & Benefits:
The anticipated annual base salary for this position ranges from $115,000 to $125,000 depending on relevant skills, experience, and education. In addition, this position is eligible for target bonus, long-term-incentives, 401k retirement savings plan with company match, and a comprehensive benefits package which includes medical, dental, vision, life, and disability insurance.
